Health implications of racial differences in serum growth differentiation factor levels among men with obesity DOI Creative Commons
Siresha Bathina,

Virginia Fuenmayor Lopez,

Mia Prado

и другие.

Physiological Reports, Год журнала: 2024, Номер 12(23)

Опубликована: Дек. 1, 2024

Growth differentiation factor (GDF15) has been considered a biomarker and recently hormonal driver for diseases in different populations. However, the role of GDF15 as health outcomes obese men from racial/ethnic background not evaluated. The objective this study was to investigate differences on relationship between markers glucometabolic status, profile, body composition bone mineral density (BMD) men. One hundred ninety-three diverse backgrounds were enrolled. BMD measured by dual energy X-ray absorptiometry. Serum GDF15, osteocalcin, C-terminal telopeptide, sclerostin, adiponectin, leptin, estradiol, testosterone, follicle-stimulating hormone, luteinizing 25-hydroxyvitamin D, lipid hemoglobin A1C (A1C) measured. Non-African Americans (NAA) had significantly higher level than African (AA). Level also patients with type 2 diabetes (T2DM). In both groups correlated lean mass. However. fat, LDL total cholesterol femoral neck only NAA appendicular mass AA. Ethnicity, T2DM found be independent predictors GDF15. We conclude that may influence parameters which affect cardiovascular risk osteoporosis races.

Язык: Английский

Health implications of racial differences in serum growth differentiation factor levels among men with obesity DOI Creative Commons
Siresha Bathina,

Virginia Fuenmayor Lopez,

Mia Prado

и другие.

Physiological Reports, Год журнала: 2024, Номер 12(23)

Опубликована: Дек. 1, 2024

Growth differentiation factor (GDF15) has been considered a biomarker and recently hormonal driver for diseases in different populations. However, the role of GDF15 as health outcomes obese men from racial/ethnic background not evaluated. The objective this study was to investigate differences on relationship between markers glucometabolic status, profile, body composition bone mineral density (BMD) men. One hundred ninety-three diverse backgrounds were enrolled. BMD measured by dual energy X-ray absorptiometry. Serum GDF15, osteocalcin, C-terminal telopeptide, sclerostin, adiponectin, leptin, estradiol, testosterone, follicle-stimulating hormone, luteinizing 25-hydroxyvitamin D, lipid hemoglobin A1C (A1C) measured. Non-African Americans (NAA) had significantly higher level than African (AA). Level also patients with type 2 diabetes (T2DM). In both groups correlated lean mass. However. fat, LDL total cholesterol femoral neck only NAA appendicular mass AA. Ethnicity, T2DM found be independent predictors GDF15. We conclude that may influence parameters which affect cardiovascular risk osteoporosis races.

Язык: Английский

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