Planta Medica, Год журнала: 2024, Номер unknown

Опубликована: Окт. 29, 2024

Abstract Painful diabetic neuropathy (PDN) is a highly prevalent complication in patients suffering from diabetes mellitus. Given the inadequate pain-relieving effect of current therapies for PDN, there high unmet medical need specialized therapeutic options. In traditional Chinese medicine (TCM), various herbal formulations have been implemented centuries to relieve pain, and one commonly used plant this context Paeonia lactiflora (P. lactiflora). Here, we summarize chemical constituents P. including their pharmacological mechanisms-of-action discuss potential benefits treatment PDN. For this, silico data, as well preclinical clinical studies, were critically reviewed comprehensively compiled. Our findings reveal that its individual exhibit variety properties relevant antinociceptive, anti-inflammatory, antioxidant, antiapoptotic activities. Through multifaceted complex combination effects, hallmarks PDN are specifically addressed, suggesting may represent promising source novel approaches

Язык: Английский