Alzheimer’s Disease as Type 3 Diabetes: Understanding the Link and Implications
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 11955 - 11955
Опубликована: Ноя. 7, 2024
Alzheimer's
disease
(AD)
and
type
2
diabetes
mellitus
(T2DM)
are
two
prevalent
conditions
that
present
considerable
public
health
issue
in
aging
populations
worldwide.
Recent
research
has
proposed
a
novel
conceptualization
of
AD
as
"type
3
diabetes",
highlighting
the
critical
roles
insulin
resistance
impaired
glucose
metabolism
pathogenesis
disease.
This
article
examines
implications
this
association,
exploring
potential
new
avenues
for
treatment
preventive
strategies
AD.
Key
evidence
linking
to
emphasizes
metabolic
processes
contribute
neurodegeneration,
including
inflammation,
oxidative
stress,
alterations
signaling
pathways.
By
framing
within
context,
we
can
enhance
our
understanding
its
etiology,
which
turn
may
influence
early
diagnosis,
plans,
measures.
Understanding
manifestation
opens
up
possibility
employing
therapeutic
incorporate
lifestyle
modifications
use
antidiabetic
medications
mitigate
cognitive
decline.
integrated
approach
improve
patient
outcomes
deepen
comprehension
intricate
relationship
between
neurodegenerative
diseases
disorders.
Язык: Английский
The Role of Genistein in Type 2 Diabetes and Beyond: Mechanisms and Therapeutic Potential
Molecules,
Год журнала:
2025,
Номер
30(5), С. 1068 - 1068
Опубликована: Фев. 26, 2025
The
global
prevalence
of
type
2
diabetes
mellitus
(T2DM)
necessitates
the
exploration
novel
therapeutic
approaches
to
mitigate
its
complex
molecular
pathogenesis.
This
review
investigates
potential
role
genistein,
a
prominent
isoflavone
derived
from
soybeans,
in
management
T2DM.
Recognized
for
selective
estrogen
receptor
modulator
(SERM)
activity,
genistein
exerts
multifaceted
influence
on
key
intracellular
signaling
pathways,
which
are
crucial
regulating
cell
proliferation,
apoptosis,
and
insulin
signaling.
Genistein's
anti-inflammatory,
anti-oxidant,
metabolic
regulatory
properties
position
it
as
promising
candidate
T2DM
intervention.
synthesizes
current
research
spanning
preclinical
studies
clinical
trials,
emphasizing
genistein's
impact
sensitivity,
glucose
metabolism,
inflammatory
markers.
Additionally,
this
addresses
bioavailability,
safety,
gut
microbiota
composition.
By
consolidating
these
findings,
aims
provide
comprehensive
understanding
management,
offering
valuable
insights
future
practice.
Язык: Английский
Red Oranges and Olive Leaf Waste-Derived Bioactive Extracts Promote Adipocyte Functionality In Vitro
Nutrients,
Год журнала:
2024,
Номер
16(12), С. 1959 - 1959
Опубликована: Июнь 19, 2024
Obesity
is
increasingly
prevalent
worldwide
and
linked
to
metabolic
diseases,
such
as
insulin
resistance
(IR)
type
2
diabetes
mellitus
(T2DM),
due
excessive
free
fatty
acids
(FFAs).
Although
lifestyle
changes
are
effective,
they
often
prove
be
insufficient
initial
treatments
for
obesity.
Additionally,
while
surgical
pharmacological
interventions
available,
not
entirely
safe
or
effective.
Recently,
interest
has
grown
in
utilizing
food
waste
plant-derived
phenolic
compounds
their
health
benefits,
presenting
a
promising
avenue
managing
obesity
its
related
disorders.
Indeed,
many
studies
have
examined
the
potential
inhibitory
effects
of
natural
extract
on
adipocyte
differentiation
lipid
accumulation.
This
study
focused
evaluation
standardized
extracts
obtained
from
red
oranges
olive
leaf
3T3-L1
murine
pre-adipocyte
functionality.
Red
orange
(ROE)
(OLE),
alone
combination,
were
tested
assess
anti-obesity
anti-inflammatory
effects,
well
therapeutic
benefits.
Three
vitro
models
established
investigate
(I)
differentiation;
(II)
mature
hypertrophic
adipocytes
challenged
with
palmitic
acid
(PA)
erastin
(ER),
respectively;
(III)
erastin-induced
cytotoxicity
pre-adipocytes.
Язык: Английский
Podocyte Death in Diabetic Kidney Disease: Potential Molecular Mechanisms and Therapeutic Targets
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 9035 - 9035
Опубликована: Авг. 20, 2024
Cell
deaths
maintain
the
normal
function
of
tissues
and
organs.
In
pathological
conditions,
abnormal
activation
or
disruption
cell
death
often
leads
to
pathophysiological
effects.
Diabetic
kidney
disease
(DKD),
a
significant
microvascular
complication
diabetes,
is
linked
high
mortality
morbidity
rates,
imposing
substantial
burden
on
global
healthcare
systems
economies.
Loss
detachment
podocytes
are
key
changes
in
progression
DKD.
This
review
explores
potential
mechanisms
apoptosis,
necrosis,
autophagy,
pyroptosis,
ferroptosis,
cuproptosis,
podoptosis
podocytes,
focusing
how
different
modes
contribute
It
recognizes
limitations
current
research
presents
latest
basic
clinical
studies
targeting
podocyte
pathways
Lastly,
it
focuses
future
treat
DKD,
with
intention
inspiring
further
development
therapeutic
strategies.
Язык: Английский