Unveiling the Miracle Tree: Therapeutic Potential of Moringa oleifera in Chronic Disease Management and Beyond
Biomedicines,
Год журнала:
2025,
Номер
13(3), С. 634 - 634
Опубликована: Март 5, 2025
Moringa
oleifera
(MO)
has
gained
recognition
as
a
potent
natural
intervention
for
preventing
and
managing
chronic
diseases
(CDs)
due
to
its
diverse
phytochemical
composition
pharmacological
properties.
Rich
in
antioxidants,
polyphenols,
flavonoids,
glucosinolates,
MO
exerts
anti-inflammatory,
anti-hyperglycemic,
cardioprotective,
anti-obesity
effects.
These
properties
make
it
valuable
therapeutic
agent
CDs,
including
diabetes,
cardiovascular
diseases,
obesity,
neurodegenerative
disorders,
cancer.
MO’s
ability
modulate
oxidative
stress
inflammation—key
drivers
of
CDs—highlights
significant
role
disease
prevention
treatment.
enhances
insulin
sensitivity,
regulates
lipid
profiles
blood
pressure,
reduces
inflammation,
protects
against
damage.
also
modulates
key
signaling
pathways
involved
cancer
liver
prevention.
Studies
suggest
that
extracts
possess
anticancer
activity
by
modulating
apoptosis,
inhibiting
tumor
cell
proliferation,
interacting
with
pathways,
YAP/TAZ,
Nrf2-Keap1,
TLR4/NF-κB,
Wnt/β-catenin.
However,
challenges
such
variability
bioactive
compounds,
taste
acceptability,
inconsistent
clinical
outcomes
limit
their
widespread
application.
While
preclinical
studies
support
efficacy,
large-scale
trials,
standardized
formulations,
advanced
delivery
methods
are
needed
optimize
potential.
multifunctional
applications
promising
sustainable
solution
combating
especially
resource-limited
settings.
Язык: Английский
Prunin: An Emerging Anticancer Flavonoid
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2678 - 2678
Опубликована: Март 16, 2025
Despite
the
substantial
advances
in
cancer
therapies,
developing
safe
and
effective
treatment
methodologies
is
critical.
Natural
(plant-derived
compounds),
such
as
flavonoids,
might
be
crucial
a
methodology
without
toxicity
toward
healthy
tissues.
Prunin
flavonoid
with
potential
to
used
biomedical
applications.
has
yet
undergo
thorough
scientific
research,
its
precise
molecular
mechanisms
of
action
remain
largely
unexplored.
This
review
summarizes
therapeutic
prunin
for
first
time,
focusing
on
underlying
an
anticancer
compound.
gained
significant
attention
due
antioxidant,
anti-inflammatory,
effects.
aims
unlock
how
functions
at
level
exert
effects,
primarily
modulating
key
cellular
pathways.
Furthermore,
we
have
discussed
prunin’s
adjunctive
therapy
conventional
treatments,
highlighting
ability
strengthen
responses
while
decreasing
drug
resistance.
Moreover,
discussion
probes
into
innovative
delivery
methods,
particularly
nanoformulations,
that
address
bioavailability,
solubility,
stability
limitations
optimize
application.
By
providing
comprehensive
analysis
properties,
this
stimulate
further
exploration
using
agent,
thereby
progressing
development
targeted,
selective,
safe,
methods.
Язык: Английский