Background:
Pro-inflammatory
cytokines
are
implicated
in
depression
caused
by
both
environmental-
and
alcohol-induced
stress.
The
purpose
of
the
study
was
to
investigate
cytokine
levels
serum
hippocampus
following
induction
depression-like
behaviors
(DLB)
either
forced
swimming
test
(FST)
or
ethanol-induced
DLB
(EID).
We
also
investigated
effect
prior
administration
antidepressant
drug
fluoxetine
on
animals
exposed
models
DLB.
Methods:
Animals
were
pretreated
with
before
inducing
DLB,
while
induced
some
using
FST
ethanol
different
groups
rats
without
pretreatment.
ELISA
used
detect
changes
(IL-1β,
IL-6,
TNF-α)
hippocampus.
Results:
mean
IL-1β
IL-6
measured
significantly
higher
EID
when
compared
control
group.
concentrations
reduced
pre-treated
5
mg/kg
10
untreated
respectively.
Conclusions:
In
conclusion,
environment
alcohol
can
induce
stress
similar
intensity,
their
mechanisms
involve
activation
pro-inflammatory
cytokines.
Moreover,
prevent
stress-induced
inflammation
BMC Bioinformatics,
Год журнала:
2024,
Номер
25(1)
Опубликована: Авг. 4, 2024
Antioxidant
proteins
are
involved
in
several
biological
processes
and
can
protect
DNA
cells
from
the
damage
of
free
radicals.
These
regulate
body's
oxidative
stress
perform
a
significant
role
many
antioxidant-based
drugs.
The
current
invitro-based
medications
costly,
time-consuming,
unable
to
efficiently
screen
identify
targeted
motif
antioxidant
proteins.
Separations,
Год журнала:
2024,
Номер
11(7), С. 204 - 204
Опубликована: Июль 1, 2024
Ferulic
acid
is
a
widespread
phenolic
compound
that
occurs
in
seeds
and
leaves,
both
its
free
form
conjugated
to
polysaccharides,
carbohydrates,
glycoproteins
lignins
the
plant
cell
walls.
It
exhibits
various
biological
activities,
like
antioxidant,
anticarcinogenic,
anti-inflammatory,
hepatoprotective,
antimicrobial,
antiviral
activity,
it
modulates
enzyme
activity.
Given
these
wide
potential
health
benefits,
ferulic
has
attracted
considerable
research
interest
may
be
considered
biomolecule
with
strong
prospects
as
functional
food
ingredient.
Great
attempts
have
been
made
enhance
extraction
process
recovery
from
natural
matrices
agro-industrial
wastes
for
applications
relating
human
nutrition.
This
review
presents
recently
available
information
on
methods
quantifying
different
samples,
along
bioavailability
stability
processing
foods
activities.
Molecules,
Год журнала:
2023,
Номер
28(15), С. 5913 - 5913
Опубликована: Авг. 6, 2023
Cedrus
atlantica
(Endl.)
Manetti
ex
Carriere
is
an
endemic
tree
possessing
valuable
health
benefits
which
has
been
widely
used
since
time
immemorial
in
international
traditional
pharmacopoeia.
The
aim
of
this
exploratory
investigation
to
determine
the
volatile
compounds
C.
essential
oils
(CAEOs)
and
examine
their
vitro
antimicrobial,
antioxidant,
anti-inflammatory,
dermatoprotective
properties.
In
silico
simulations,
including
molecular
docking
pharmacokinetics
absorption,
distribution,
metabolism,
excretion,
toxicity
(ADMET),
drug-likeness
prediction
were
reveal
processes
underlying
biological
Gas
chromatography-mass
spectrophotometry
(GC-MS)
was
for
chemical
screening
CAEO.
antioxidant
activity
CAEO
investigated
using
four
complementary
techniques,
ABTS
DPPH
radicals
scavenging
activity,
ferric
reductive
power,
inhibition
lipid
peroxidation
(β-carotene
test).
Lipoxygenase
(5-LOX)
tyrosinase
inhibitory
assays
testing
anti-inflammatory
GC-MS
analysis
indicated
that
main
components
are
β-himachalene
(28.99%),
α-himachalene
(14.43%),
longifolene
(12.2%).
An
antimicrobial
examined
against
eleven
strains
Gram-positive
bacteria
(three
strains),
Gram-negative
(four
fungi
strains).
results
demonstrated
high
antibacterial
antifungal
ten
them
(>15
mm
zone
inhibition)
disc-diffusion
assay.
microdilution
test
showed
lowest
values
MIC
MBC
recorded
with
particular,
ranged
from
0.0625
0.25
%
v/v
0.5
0.125
MBC.
MFC
fungal
4.0%
(MIC)
8.0%
(MFC).
According
MBC/MIC
MFC/MIC
ratios,
bactericidal
fungicidal
activity.
revealed
possesses
remarkable
effects
on
5-LOX
enzymes
also
significant
(p
<
0.05).
ADMET
suggests
possess
favorable
pharmacokinetic
These
findings
provide
scientific
validation
uses
plant
suggest
its
potential
application
as
natural
drugs.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Фев. 15, 2024
Abstract
Reactive
oxygen
species
reacts
with
numerous
molecules
in
the
body
system
causing
oxidative
damage,
which
requires
antioxidants
to
ameliorate.
Pleurotus
ostreatus
,
a
highly
nutritious
edible
mushroom,
has
been
reported
be
rich
bioactive
compounds.
This
study
evaluated
comparative
antioxidant
activity
and
phytochemical
contents
of
five
extracts
P.
:
aqueous
(AE),
chloroform
(CE),
ethanol
(EE),
methanol
(ME)
n-hexane
(HE).
The
composition
were
determined
using
standard
in-vitro
assay
methods.
Results
showed
that
contained
alkaloids,
tannins,
saponins,
flavonoids,
terpenoids,
phenolics,
cardiac
glycosides,
carbohydrates,
anthrocyanins,
betacyanins
varied
amounts.
CE
had
highest
flavonoid
content
(104.83
±
29.46
mg/100
g);
AE
gave
phenol
24.14
0.02
g;
tannin
was
EE
(25.12
0.06
HE
amounts
alkaloids
(187.60
0.28
g)
saponins
(0.16
0.00
g).
Antioxidant
analyses
revealed
best
hydroxyl
radical
250%
at
100
µg/ml
ferric
cyanide
reducing
power
8495
µg/ml;
ME
maximum
DPPH
(87.67%)
hydrogen
peroxide
scavenging
(65.58%)
500
nitric
oxide
inhibition
65.81%
ascorbate
peroxidase
1.60
(iU/l).
total
capacity
(5.27
GAE
µg/ml)
ferrous
iron
chelating
(99.23%
while
guaiacol
0.20(iU/l).
characteristics
(IC
50
)
followed
order:
>
HE.
Overall,
extraction
solvent
for
.
high
phenolic
compounds,
makes
it
source
potential
candidate
development
new
therapies
variety
stress-related
disorders.
This
general
review
assesses
the
impact
of
physical
exercise
on
oxidative
and
nitrosative
stress
counteractive
role
antioxidants,
drawing
from
a
systematic
literature
search
up
to
March
2024
in
databases
like
PubMed
Web
Science.
The
highlights
studies
effect
production
reactive
oxygen
species
(ROS)
nitrogen
(RNS)
antioxidant
responses
both
human
animal
models
based
rigorous
inclusion
exclusion
criteria.
Due
variety
types
participants'
characteristics,
narrative
synthesis
approach
was
adopted.
findings
indicate
that
moderate
boosts
defenses,
known
as
hormesis,
whereas
excessive
activity
may
increase
damage.
also
explores
complex
effects
supplementation,
revealing
while
natural
dietary
antioxidants
support
health,
high-dose
supplements
could
potentially
hinder
positive
adaptations
exercise.
Recommendations
for
athletes
active
population
highlight
importance
balancing
intake
optimize
health
benefits.
concludes
with
call
more
detailed
research
tailored
nutrition
plans
dissect
these
intricate
relationships
further.
Antioxidants,
Год журнала:
2024,
Номер
13(5), С. 573 - 573
Опубликована: Май 7, 2024
This
review
comprehensively
evaluates
the
effects
of
physical
exercise
on
oxidative
and
nitrosative
stress,
mainly
focusing
role
antioxidants.
Using
a
narrative
synthesis
approach,
data
from
empirical
studies,
reviews,
systematic
meta-analyses
published
between
2004
2024
were
collated
databases
like
PubMed,
EBSCO
(EDS),
Google
Scholar,
culminating
in
inclusion
41
studies.
The
quality
these
studies
was
rigorously
assessed
to
ensure
clarity
objectives,
coherence
arguments,
comprehensive
literature
coverage,
depth
critical
analysis.
Findings
revealed
that
moderate
enhances
antioxidant
defenses
through
hormesis,
while
excessive
may
exacerbate
stress.
also
highlights
natural
dietary
antioxidants
are
beneficial,
high-dose
supplements
could
impede
positive
adaptations
exercise.
In
conclusion,
calls
for
more
focused
research
tailored
nutrition
plans
further
understand
complex
interactions
optimize
health
outcomes
athletes
general
population.
Journal of Nutrition and Metabolism,
Год журнала:
2024,
Номер
2024(1)
Опубликована: Янв. 1, 2024
Lycopene
is
a
naturally
occurring
carotenoid
predominantly
found
in
tomatoes
and
tomato‐based
products.
Like
other
phytochemicals,
it
exhibits
health
beneficial
biological
activities
that
can
be
exploited
when
used
as
dietary
supplement.
In
vitro
vivo
,
lycopene
has
been
demonstrated
to
mitigate
oxidative
stress‐induced
metabolic
dysfunctions
diseases
including
inflammation,
obesity,
diabetes
mellitus.
shown
alleviate
affect
the
bone,
eye,
kidney,
liver,
lungs,
heart,
nervous
system.
This
review
presents
state
of
art
regarding
lycopene’s
benefits
its
potential
applications
system
delivery.
Furthermore,
protective
effects
against
toxins,
safety
use,
possible
toxicity
are
explored.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Сен. 20, 2023
Introduction
Bisphenol
F
(BPF)
has
been
shown
to
disrupt
testicular
functions
via
perturbation
of
redox
balance,
while
omega-3
fatty
acid
(O3FA)
established
exert
antioxidant
and
anti-inflammatory
activities.
Therefore,
this
study
focused
on
the
role
associated
molecular
mechanism
O3FA
in
BPF-induced
dysfunction
male
Wistar
rats.
Methods
Twenty-four
(24)
rats
were
randomly
grouped
after
two
weeks
acclimatization
into
four
(4)
groups
(n=6/group);
vehicle-treated
control
group,
BPF
treated
group
received
30
mg/kg
BPF,
intervention
+
100
(BPF+O3FA-L)
300
(BPF+O3FA-H).
All
treatment
lasted
for
28
days.
Results
Low
high
doses
ameliorated
BPF-impaired
sperm
quality,
induced
hormonal
imbalance,
accompanied
by
a
distortion
histology
elevated
injury
markers.
Furthermore,
co-administration
with
both
blunted
inflammatory
response,
apoptosis.
Discussions
In
conclusion,
our
present
findings
show
that
improves
BPF-treated
improving
quality
reproductive
hormones
maintenance
balance.
Antioxidants,
Год журнала:
2023,
Номер
12(7), С. 1390 - 1390
Опубликована: Июль 6, 2023
Cannabis
leaves
contain
a
diverse
range
of
antioxidants,
including
cannabinoids,
flavonoids,
and
phenolic
compounds,
which
offer
significant
health
benefits.
Utilising
cannabis
as
source
antioxidants
presents
cost-effective
approach
because
they
are
typically
discarded
during
the
cultivation
plants
for
their
seeds
or
fibres.
Therefore,
this
presented
study
aimed
to
assess
antioxidant
activity
selected
hemp
cultivars,
such
Białobrzeska,
Tygra,
Henola,
based
on
results
obtained
with
2,2'-Azino-bis(3-ethylbenzthiazoline-6-sulfonic
acid,
ferric
reducing
power,
cupric
capacity,
2,2-Diphenyl-1-picrylhydrazyl
assays.
The
cannabinoid
profile
was
analysed
contents
cannabidiol
(CBD),
cannabigerol
(CBG),
Δ9-tetrahydrocannabinol
(Δ9-THC),
cannabichromene
(CBC),
determined
chromatographic
following
variables
were
tested:
impact
various
extractants
(methanol,
ethanol,
isopropanol),
mixtures
(50:50,
v/v,
well
extraction
methods
(maceration
ultra-sound-assisted
extraction)
in
obtaining
extracts
characterised
by
different
profiles.
revealed
that
selection
extractant
conditions
significantly
influenced
active
compounds'
efficiency
activity.
Among
tested
conditions,
ultrasound-assisted
using
methanol
yielded
highest
profile:
CBD
=
184.51
±
5.61;
CBG
6.10
0.21;
Δ9-THC
0.51
0.01;
CBC
0.71
0.01
μg/g
potential
Białobrzeska
leaf
extracts.
