Anti-Cancer potential of a new Derivative of Caffeic Acid Phenethyl Ester targeting the centrosome

Redox Biology, Год журнала: 2025, Номер 81, С. 103582 - 103582

Опубликована: Март 5, 2025

Anaplastic Large Cell Lymphoma (ALCL) is an aggressive T-cell lymphoma affecting children and young adults. About 30% of patients develop therapy resistance therefore new precision medicine drugs are highly warranted. Multiple rounds structure-activity optimization Caffeic Acid Phenethyl Ester have resulted in CM14. CM14 causes upregulation genes involved oxidative stress response downregulation DNA replication leading to G2/M arrest subsequent apoptosis induction. In accordance with this, unbiased proteomics approach, confocal microscopy molecular modeling showed that TUBGCP2, member the centrosomal γ-TuRC complex, a direct interaction partner overcomes ALK inhibitor ALCL also active Acute Lymphoblastic Leukemia Myeloid Leukemia. Interestingly, induced cell death docetaxel-resistant prostate cancer cells thus suggesting unexpected role solid cancers. Thus, we synthesized thoroughly characterized novel TUBGCP2 targeting drug but has potential for other malignancies.

Язык: Английский

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Mediterranean Diet Modulation of Neuroinflammation-Related Genes in Elderly Adults at High Cardiovascular Risk

Nutrients, Год журнала: 2024, Номер 16(18), С. 3147 - 3147

Опубликована: Сен. 18, 2024

Individuals with dementia and neurodegenerative diseases (NDDs) often suffer from cardiovascular (CVDs). Neuroinflammation driven by conditions involved in CVDs is linked to disruptions the central nervous system triggering immune reactions, perpetuating an “inflammatory-like” environment. The Mediterranean diet (MedDiet), known for its anti-inflammatory antioxidant properties, has been proposed as a key factor attenuate these risks. Blood nuclear cell samples were collected 134 participants of PREDIMED trial, which randomized three diets: one supplemented extra-virgin olive oil (MedDiet-EVOO), another nuts (MedDiet-Nuts), low-fat control diet. These analyzed at baseline 12-month follow-up assess impact dietary interventions on gene expression markers. We first selected target genes analyzing intersections between NDD CVD associations. Significant changes 12 months observed allocated MedDiet-EVOO, particularly CDKN2A, IFNG, NLRP3, PIK3CB, TGFB2. Additionally, TGFB2 changed over time MedDiet-Nuts group. Comparative analyses showed significant differences MedDiet-EVOO control, NAMPT control. Longitudinal models adjusted different covariates also revealed effects NAMPT. In conclusion, our results suggest that year traditional MedDiet, especially modulates associated risk NDDs older adults high CV risk.

Язык: Английский

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Aging and Bioenergetics of Mitochondria

Advances in biochemistry in health and disease, Год журнала: 2024, Номер unknown, С. 285 - 303

Опубликована: Янв. 1, 2024

Язык: Английский

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