Organocatalytic Synthesis of α-Aminonitriles: A Review
Catalysts,
Год журнала:
2022,
Номер
12(10), С. 1149 - 1149
Опубликована: Окт. 1, 2022
α-Aminonitriles,
which
have
anticancer,
antibacterial,
antiviral,
and
antifungal
properties,
played
an
important
role
in
pharmacology.
Furthermore,
they
can
also
be
used
to
synthesize
natural
unnatural
amino
acids.
The
main
bottleneck
the
commercialization
of
these
products
is
their
large-scale
production
with
controlled
chirality.
A
variety
methods
been
α-aminonitriles.
Among
other
reported
for
preparing
α-aminonitriles,
Strecker
reaction
considered
appropriate.
Recent
developments,
however,
enabled
α-cyanation
tertiary
secondary
amines
by
functionalizing
carbon–hydrogen
(C–H)
bond
as
attractive
alternative
procedure
preparation
α-aminonitriles
presence
oxidant
a
cyanide
source.
In
most
cases,
reactions
are
catalyzed
transition
metal
catalysts,
such
Fe,
Cu,
Rh,
V,
Au,
Ru,
Mo,
Pt,
Re,
Co,
or
photocatalysts.
As
alternative,
organocatalysts
produce
aminonitriles.
Although
there
numerous
reviews
on
no
published
specifically
organocatalyzed
synthesis
Organocatalysis
plays
significant
synthesizing
via
Strecker-type
cross
dehydrogenative
coupling
(CDC).
this
mini
review,
we
discuss
molecules.
review
new
aminonitriles
expected
provide
insight
into
development
industrial
catalysts.
Язык: Английский
Design of Threonine‐Derived Amino Sulfonamide Organocatalysts for the Highly Stereoselective Aldol Reactions
Asian Journal of Organic Chemistry,
Год журнала:
2023,
Номер
12(8)
Опубликована: Март 30, 2023
Abstract
Novel
threonine‐derived
amino
sulfonamide
organocatalysts
were
developed
and
applied
to
the
asymmetric
aldol
reactions.
The
reactions
of
cyclohexanones
with
aromatic
aldehydes
catalyzed
by
tosylamide
provided
anti
‐aldol
adducts
in
good
yield
high
diastereo‐
enantioselectivity.
On
other
hand,
syn
obtained
between
α‐siloxyacetone
using
triflamide
catalyst.
In
both
cases,
a
significant
improvement
diastereoselectivity
was
observed
compared
carboxylic
acid
Язык: Английский