Analytical Sciences,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 8, 2024
Nateglinide
is
an
oral
meglitinide
that
treats
diabetes.
was
determined
in
several
commercial
formulations
using
chromatographic
and
spectrophotometric
methods
published
research.
Quality-by-design
approach
applied
to
develop
the
in-house
nateglinide-loaded
Solid
Dispersion
Adsorbate
(SDA)
for
improving
bioavailability
solubility.
To
determine
nanogram-level
nateglinide
concentration
developed
nateglinide-SDA
pharmacokinetics
required
time-consuming
expensive
hyphenated
analytical
techniques
such
as
LC-MS
or
UPLC-MS.
Hence,
a
sensitive
spectrofluorophotometric
method
estimate
NBD-Cl
(7-chloro-4-nitrobenzoxadiazole)
fluorophore.
Microwave-aided
chemical
derivatization
of
with
sped
up
sample
analysis.
Chemical
reaction
solvents
were
eco-friendly
safeguard
aquatic
life
environment.
The
process
optimized
by
quality
design
screening
response
surface
modelling.
fluorescence
intensity
found
be
linear
over
range
20–250
ng/mL
correlation
coefficient
0.9978.
limits
detection
quantification
10
20
respectively.
Precision
robustness
investigations
spectrofluorimetric
showed
less
than
2%
relative
standard
deviations.
Nateglinide-SDA
drug-release
study
performed
method.
released
95%
drug
30
min
time
duration.
In-house-developed
has
1.5
times
due
in-vivo
absorption.
compared
enhanced-spectrofluorophotometric
user-friendliness,
efficiency,
cost-of-analysis,
environmental
friendliness.
proposed
sensitive-spectrofluorophotometric
robust,
rapid,
eco-friendly,
cost-effective,
simple
estimation
nateglinide.
Journal of Chromatography Open,
Год журнала:
2024,
Номер
5, С. 100135 - 100135
Опубликована: Май 1, 2024
Reverse-phase
liquid
chromatography
has
been
a
widely
used
analytical
technique
in
many
laboratories
around
the
world
for
several
decades.
In
reverse-phase
method
development
applications,
majority
of
chemists,
use
organic
phase
modifiers
is
limited
to
acetonitrile
and
methanol.
an
effort
minimise
impact
on
environment
while
improving
analyst
health
safety,
seen
rise
interest
greening
procedures,
including
environmentally
friendly
alternative
modifiers.
Another
focus
exploring
maximise
selectivity
space
typically
octadecylsiloxane-bonded
silica
stationary
phase.
The
aim
this
review
explore
how
chemists
employed
solvents
as
various
applications
their
retention
properties.
Archiv der Pharmazie,
Год журнала:
2024,
Номер
357(9)
Опубликована: Июнь 18, 2024
Green
and
white
chemistry
are
vital
to
revolutionizing
the
chemical
industry
through
their
unparalleled
potential
enhance
sustainability
efficiency.
In
this
study,
nine
tools
of
both
green
metrics,
including
analytical
procedure
index
(GAPI),
ComplexGAPI,
greenness,
greenness
metric
for
sample
preparation,
Analytical
Eco-Scale
(ESA),
method
score,
high-performance
liquid
chromatography-
environmental
assessment
tool
(HPLC-EAT),
volume
intensity,
blue
applicability
grade
(BAGI),
have
been
developed
appraising
friendliness
innovative
straightforward
mean
centering
ratio
spectra
(MCR)
reversed-phase
chromatography
(RP-HPLC)
strategies
utilized
concurrent
analysis
separation
cyclopentolate
(CYC)
C12
C14
homologs
benzalkonium
chloride
(BNZ)
in
pure
ophthalmic
solution.
The
mobile
phase,
formed
buffer
phosphate
acetonitrile
(35:65,
v/v),
was
adjusted
pH
6.3,
215-nm
UV
detection
used.
experimental
flow
rate
2.0
mL
min
RSC Advances,
Год журнала:
2025,
Номер
15(11), С. 8675 - 8695
Опубликована: Янв. 1, 2025
Salbutamol
sulfate
(SAL)
and
prednisolone
(PRD)
are
commonly
used
for
treating
respiratory
inflammatory
conditions,
yet
they
frequently
detected
in
aquatic
ecosystems,
posing
significant
risks
to
life
biodiversity.
Despite
the
growing
concern
over
pharmaceutical
pollution,
there
is
a
lack
of
reliable
sustainable
methods
quantifying
these
drugs
both
environmental
samples,
as
well
effective
adsorbents
their
removal
from
contaminated
water.
This
study
aims
fill
this
gap
by
developing
reversed-phase
high-performance
liquid
chromatography
(RP-HPLC)
method
SAL
PRD,
while
also
creating
an
organoclay-activated
carbon
composite
adsorbent
removing
The
HPLC
was
validated
linearity,
precision,
accuracy,
robustness,
specificity,
with
detection
limits
1.06
μg
mL-1
0.95
PRD.
demonstrated
high
efficiency
drugs,
achieving
maximum
adsorption
capacities
731.64
mg
g-1
888.75
PRD
at
pH
7,
dose
0.4
g
temperature
45
°C.
Thermodynamic
analysis
revealed
that
process
endothermic
spontaneous.
Characterization
using
FTIR,
SEM,
XRD,
BET
confirmed
its
structure.
Adsorption
followed
Langmuir
model
Sips
equilibrium
reached
within
240
minutes
following
pseudo-second-order
kinetics.
Ethanol
proved
more
than
acetone
acetic
acid
desorbing
SAL,
found
be
cost-effective,
offering
practical
solution
large-scale
water
treatment.
Sustainability
assessments
ComplexGAPI,
BAGI,
RGB
12
algorithms
highlighted
strong
friendliness.
research
provides
valuable
insights
quality
control
remediation
pollutants.
International Journal of Environmental & Analytical Chemistry,
Год журнала:
2024,
Номер
unknown, С. 1 - 20
Опубликована: Июль 26, 2024
Coal
Fly
Ash
(FA)
and
modified
fly
ash
(mFA),
treated
with
either
KOH
or
NaOH,
were
used
to
remove
methylene
blue
(MB)
crystal
violet
(CV)
dyes
from
aqueous
solution.
Several
techniques,
including
Thermogravimetric
analysis,
X-Ray
diffraction
Fourier-transform
infrared
spectroscopy,
Brunauer-Emmett-Teller,
Scanning
Electron
Microscopy,
characterise
both
FA
mFA.
To
optimise
the
adsorption
process,
Response
Surface
Methodology
(RSM)
Box
–
Behnken
design
(BBD)
was
applied.
Key
parameters
such
as
solution
pH
(4–10),
initial
dye
concentration
(200–300
mg/L),
contact
time
(15–180
minutes),
temperature
(30–50°C)
varied
assess
their
impact
on
efficiency.
The
followed
Langmuir
model
pseudo-second-order
(PSO)
kinetic
model.
capacity
of
mFA
for
MB
49.5
mg/g
at
50°C,
while
CV
dye,
it
495.5
same
temperature.
mechanism
involved
electrostatic
attraction,
n-π
interaction,
Yoshida
hydrogen
bonding,
bonding.
These
results
highlight
effectiveness
a
high-capacity
adsorbent
treating
in
water
solutions.
