Aerobic training and vitamin D modulate hepatic miRNA expression to improve lipid metabolism and insulin resistance in type 2 diabetes
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Май 14, 2025
The
prevalence
of
type
2
diabetes
mellitus
(T2DM)
has
reached
epidemic
proportions
globally,
posing
a
significant
burden
on
public
health.
Dysregulation
lipid
metabolism
and
insulin
resistance
in
T2DM
often
leads
to
hepatic
complications,
making
the
modulation
microRNAs
(miRNAs)
associated
with
these
pathways
promising
therapeutic
target.
This
study
aimed
investigate
protective
effects
aerobic
training
(AT)
vitamin
D
supplementation
liver
individuals
by
examining
miRNAs
related
resistance.
Specifically,
examined
this
were
miR-33,
miR-122,
miR-29,
miR-9.
Thirty-two
male
Wistar
rats
randomly
assigned
four
groups:
Control
(C),
AT,
moderate
dose
Vitamin
(MD;
5,000
IU),
high
(HD;
10,000
IU).
AT
group
underwent
an
eight-week
program
consisting
treadmill
running
sessions,
five
days
per
week,
gradual
increase
intensity
duration.
groups
received
either
or
IU
D,
administered
via
injection
once
weekly
for
8
weeks.
used
STZ
+
HFD
rat
model
collected
tissue
samples
analysis.
Total
RNA,
including
miRNA,
was
extracted
from
samples,
miRNA
expression
levels
quantified
using
quantitative
real-time
PCR
(qRT-PCR).
Statistical
analyses
performed
one-way
ANOVA
followed
Tukey's
post
hoc
test.
led
significantly
lower
fasting
plasma
(p
<
0.05)
notable
improvement
homeostatic
assessment
(HOMA-IR)
index,
indicating
enhanced
sensitivity
compared
control
other
groups.
It
also
resulted
triglyceride
0.01)
favorable
shift
HDL/LDL
ratio,
indicative
improved
metabolism.
showed
dose-dependent
reduction
resistance,
demonstrating
more
pronounced
group.
Rats
supplemented
exhibited
profile,
decrease
triglycerides
ratio.
miR-9
differed
among
experimental
downregulation
miR-122
while
showing
upregulation
miR-33
miR-29
C
MD
HD
Both
high-dose
have
beneficial
levels,
modulating
expression,
thereby
inhibiting
improving
T2DM.
Язык: Английский
The impact of physical exercise modalities in lowering blood glucose levels in diabetes mellitus patients: a systematic review
Опубликована: Май 26, 2025
Background.
Diabetes
mellitus
is
a
chronic
condition
characterized
by
hyperglycemia
due
to
the
body's
inability
use
insulin
effectively.
This
metabolic
disorder
occurs
when
cannot
function
optimally
maintain
blood
glucose
balance.
Physical
exercise
non-pharmacological
therapy
that
offers
significant
health
benefits,
particularly
for
individuals
with
diabetes
mellitus.
Aim.
The
purpose
of
this
review
assess
role
physical
in
reducing
levels
type
2
diabetes.
Methods.
A
systematic
was
conducted
examining
journal
databases
including
PubMed,
Embase,
ScienceDirect,
Web
Science,
and
Scopus.
Inclusion
criteria
focused
on
studies
from
past
five
years
involving
mellitus,
exercise,
control.
total
850
articles
were
identified,
which
nine
peer-reviewed
selected
based
relevance
quality.
study
followed
PRISMA
(Preferred
Reporting
Items
Systematic
Reviews
Meta-Analyses)
guidelines.
Results.
findings
consistently
show
contributes
reduction
patients
Conclusion.
has
been
confirmed
as
an
effective
intervention
lowering
enhancing
overall
limited
evaluating
general
effects
activity
without
differentiating
between
specific
types.
Future
research
should
compare
relative
effectiveness
aerobic
versus
anaerobic
regulation.
Язык: Английский
Translational exercise biomedicine – where do we go?
Deleted Journal,
Год журнала:
2024,
Номер
1(1), С. 1 - 4
Опубликована: Март 15, 2024
Язык: Английский
Glucose transporters and their energy homeostasis function in various organs
U Nithya,
R C Theijeswini,
Karthick Raja R
и другие.
Vitamins and hormones,
Год журнала:
2024,
Номер
unknown, С. 1 - 47
Опубликована: Авг. 24, 2024
Язык: Английский
Physical Exercise and Mental Health in Adolescents: Scoping Review
Revista de Investigación e Innovación en Ciencias de la Salud,
Год журнала:
2024,
Номер
unknown, С. press - press
Опубликована: Окт. 22, 2024
Objective.
To
identify
the
most
implemented
exercises
and
their
prescription,
in
addition
to
effects
of
exercise
on
mental
health
adolescents.
Methods.
A
scoping
review
was
performed
from
search
electronic
databases:
PubMed,
Science
Direct,
Scopus,
Springer,
Google
Scholar,
23/08/2023
01/01/2024
English,
Spanish,
Portuguese
language,
including
randomized
clinical
trial
cohort
type
studies.
Results.
total
7
articles
were
included:
57.14%
controlled
trials,
100%
English.
The
number
participants
85,637
aged
12
16
years.
Intervention
time
ranged
8
43
weeks,
2
5
times
per
week,
1
session
day,
duration
10
120
minutes.
used
training
Programmed
Physical
Education
followed
by
High
Intensity
Interval
Training.
Conclusions.
Exercises
such
as
Education,
Training,
Moderate
Vigorous
Activity
are
included,
which
show
positive
increase
psychological
well-being,
quality
life
a
significant
decrease
anxiety
stress
symptoms.
Язык: Английский