Malignancy Spectrum,
Год журнала:
2024,
Номер
1(4), С. 263 - 274
Опубликована: Дек. 1, 2024
Abstract
Lung
cancer
is
the
leading
malignancy
among
males
and
ranks
second
in
females,
with
an
estimated
two
million
new
diagnoses
annually.
It
first
cancer‐related
deaths
men
second,
following
breast
cancer,
women.
The
most
significant
risk
factor
for
lung
smoking.
There
are
main
types
of
cancer:
non‐small
cell
(NSCLC)
small
(SCLC),
about
85%
cases
falling
into
NSCLC
category.
Even
a
combination
treatments
NSCLC,
such
as
surgical
intervention,
chemotherapy,
radiation
therapy,
immunotherapy,
5‐year
survival
rates
those
diagnosed
advanced
have
not
reached
satisfactory
levels,
chemotherapy
continuing
to
be
therapeutic
approach.
In
treatment,
gemcitabine
platinum‐based
agents
applied
first‐line
therapy.
However,
acquired
or
pre‐existing
drug
resistance
can
prevent
chemotherapeutic
from
achieving
expected
effect
on
patients
increasing
dose
lead
increase
side
effects.
recent
years,
these
reasons,
there
has
been
increased
interest
phytochemicals
enhance
cytotoxic
effects
cells
while
minimizing
their
toxic
healthy
tissues.
One
studied
curcumin.
Despite
its
anticancer
cells,
low
stability
poor
pharmacokinetics
led
unsatisfactory
results
studies.
Therefore,
variety
analogs
synthesized.
This
review
explores
impact
curcumin
pathways
death
NSCLC.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Anemia
is
a
potentially
life-threatening
blood
disorder
caused
by
an
insufficient
erythroblast
volume
in
the
circulatory
system.
Self-renewal
failure
of
progenitors
one
key
pathological
factors
leading
to
deficiency.
However,
there
are
currently
no
effective
drugs
that
selectively
target
this
process.
In
work,
we
present
carbon
dot
(CP-CDs)
derived
from
phytochemicals
significantly
promotes
self-renewal
for
anemia
therapy.
As
superoxide
dismutase
(SOD)-like
nanozyme,
CP-CDs
activate
hypoxia
response
and
JAK/STAT3
pathways
erythroid
cells
reprogramming
oxidative
stress
state.
This
results
unique
erythropoiesis-enhancing
properties
promoting
generation
progenitor
cells.
Moreover,
protect
mature
red
inhibiting
stress-induced
damage
improving
immune-inflammatory
microenvironment.
vivo,
showed
promising
therapeutic
effect
mouse
zebrafish
models
with
minimal
adverse
effects,
indicating
significant
translational
medical
value.
Collectively,
study
not
only
illustrates
successful
approach
nanomedicine-enhanced
therapy
but
also
enhances
our
understanding
interaction
between
nanomedicine
progenitors.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Abstract
Mitochondrial
quality
control
is
paramount
for
cellular
development,
with
mitochondrial
electron
flow
(Mito‐EF)
playing
a
central
role
in
maintaining
homeostasis.
However,
unlike
visible
protein
entities,
which
can
be
monitored
through
chemical
biotechnology,
regulating
by
invisible
entities
such
as
Mito‐EF
has
remained
elusive.
Here,
tracker
(Mito‐EFT)
four‐pronged
probe
design
presented
to
elucidate
the
dynamic
mechanisms
of
Mito‐EF's
involvement
control.
Heightened
aggregation
fiber‐like
healthy
mitochondria
compared
round‐like
damaged
demonstrated,
revealed
correlated
morphological
remodeling,
particularly
regions
undergoing
fission
and
fusion,
show
signal
associated
cristae
maintained
Dynamin‐Related
Protein
1
(DRP1).
This
underscores
importance
considering
assessing
parameters.
A
novel
drug
screening
evaluation
parameter,
also
introduced
screen
discover
mitochondrial‐targeted
therapeutic
modulators.
provides
new
avenues
investigating
homeostasis
control,
offering
potent
tool
screening.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 11, 2025
This
work
examines
the
anticancer
activity,
anti-inflammatory
nature,
and
cytotoxicity
of
ethanol
extract
obtained
from
female
flowers
Cannabis
sativa
L
using
molecular
methods
in
vitro
,
animal
testing
vivo
as
well
computational
simulations
silico
.
From
GC-MS
analysis,
following
bioactive
compounds
were
found:
cannabidiol
(CBD),
tetrahydrocannabinol
(THC),
humulene.
The
antiproliferative
activities
determined
on
HeLa
cells
by
MTT,
Crystal
Violet,
Trypan
Blue
assays
with
an
IC50
value
suggesting
51%-77.6%
lethality.
bioinformatics
analysis
docking
proved
significant
ligand-protein
interactions
CBD,
THC,
humulene
cancer-associated
proteins
such
PD-1/PD-L1,
TNF-α,
MMP-9.
In
breast
cancer
was
first
established
Sprague-Dawley
rats
7,12-dimethylbenz(a)anthracene
(DMBA)
then
treated
cannabinoids
either
singularly
or
combination.
Detailed
treatment
demonstrated
that
use
three
simultaneously
yielded
best
outcomes
together
tumor
reduction.
concentration
serum
biomarkers
inflammation
progression
substantially
reduced
groups
compared
to
control
group,
which
proves
synergistic
effects
these
therapy.
study
emphasizes
importance
medical
derivatives
treatment.
