Transcriptomic correlates of state modulation in forebrain interneurons: A cross-species analysis DOI Creative Commons
Joram Keijser, Loreen Hertäg, Henning Sprekeler

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Дек. 4, 2023

Abstract GABAergic inhibitory interneurons comprise many subtypes that differ in their molecular, anatomical and functional properties. In mouse visual cortex, they also modulation with an animal’s behavioural state, this state can be predicted from the first principal component (PC) of gene expression matrix. Here, we ask whether link between transcriptome state-dependent processing generalises across species. To end, analysed seven single-cell single-nucleus RNA sequencing datasets mouse, human, songbird, turtle forebrains. Despite homology at level cell types, found clear differences transcriptomic PCs, greater dissimilarities evolutionarily distant These arise two factors: divergence within homologous types type abundance. We compare cholinergic receptors, which are thought to causally modulation. Several receptors predictive differentially expressed Circuit modelling mathematical analyses suggest conditions under these could translate into differences.

Язык: Английский

Neocortical somatostatin neuron diversity in cognition and learning DOI Creative Commons
Eunsol Park, Matthew B. Mosso, Alison L. Barth

и другие.

Trends in Neurosciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Auditory cortex ensembles jointly encode sound and locomotion speed to support sound perception during movement DOI Creative Commons

Carlos Arturo Vivaldo,

Joonyeup Lee,

MaryClaire Shorkey

и другие.

PLoS Biology, Год журнала: 2023, Номер 21(8), С. e3002277 - e3002277

Опубликована: Авг. 31, 2023

The ability to process and act upon incoming sounds during locomotion is critical for survival adaptive behavior. Despite the established role that auditory cortex (AC) plays in behavior- context-dependent sound processing, previous studies have found cortical activity on average suppressed as compared immobility. While suppression of responses self-generated results from corollary discharge, which weakens predictable sounds, functional weaker unpredictable external remains unclear. In particular, whether sound-evoked reflects reduced involvement AC processing or it masking by an alternative neural computation this state unresolved. Here, we tested hypothesis rather than simple inhibition, reflect a tradeoff with emergence explicit reliable coding velocity. To test hypothesis, first used inactivation behaving mice sound-guided behavior locomotion. investigate nature two-photon calcium imaging local excitatory populations awake mice. We had diverse influences different neurons, net baseline-subtracted stimulus detection, consistent studies. Importantly, inhibitory effect was strongly shaped elevated ongoing compressed response dynamic range, reflecting enhanced “noise,” reliably encoded animal’s speed. Decoding analyses revealed speed are robustly co-encoded ensemble activity. Finally, patterns joint electrophysiologically recorded freely moving rats. Together, our data suggest being locomotion, ensembles explicitly encode alongside information support perception

Язык: Английский

Процитировано

19
Different state-dependence of population codes across cortex DOI Creative Commons
Akhil Bandi, Caroline A. Runyan

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 26, 2024

During perceptual decision-making, behavioral performance varies with changes in internal states such as arousal, motivation, and strategy. Yet it is unknown how these affect information coding across cortical regions involved differing aspects of sensory perception decision-making. We recorded neural activity from the primary auditory cortex (AC) posterior parietal (PPC) mice performing a navigation-based sound localization task. then modeled transitions strategies used during task performance. Mice transitioned between three latent decision-making strategies: an 'optimal' state two 'sub-optimal' characterized by choice bias frequent errors. Performance strongly influenced population patterns association but not cortex. Surprisingly, individual PPC neurons was better explained external inputs variables suboptimal than optimal state. Furthermore, shared variability (coupling) strongest In AC, similarly weak all states. Together, findings indicate that more linked to

Язык: Английский

Процитировано

0
Transcriptomic correlates of state modulation in forebrain interneurons: A cross-species analysis DOI Creative Commons
Joram Keijser, Loreen Hertäg, Henning Sprekeler

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Дек. 4, 2023

Abstract GABAergic inhibitory interneurons comprise many subtypes that differ in their molecular, anatomical and functional properties. In mouse visual cortex, they also modulation with an animal’s behavioural state, this state can be predicted from the first principal component (PC) of gene expression matrix. Here, we ask whether link between transcriptome state-dependent processing generalises across species. To end, analysed seven single-cell single-nucleus RNA sequencing datasets mouse, human, songbird, turtle forebrains. Despite homology at level cell types, found clear differences transcriptomic PCs, greater dissimilarities evolutionarily distant These arise two factors: divergence within homologous types type abundance. We compare cholinergic receptors, which are thought to causally modulation. Several receptors predictive differentially expressed Circuit modelling mathematical analyses suggest conditions under these could translate into differences.

Язык: Английский

Процитировано

0