Editorial: Neural and behavioral mechanisms of social learning

Frontiers in Human Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Фев. 13, 2025

Neural and Behavioral Mechanisms of Social Learning 12 13 learning, the acquisition new information or behavior through observation instruction 14 by other organisms, has been observed in a host species [1][2][3]. Humans particular rely heavily 15 on social learning strategies to acquire distribute between individuals across 16 generations [4]. Moreover, access opportunities is essential for normative 17 behavioral cognitive development, as evidenced persistent deficits 18 deprived contact early life. In accordance with clear importance this 19 transfer method, much research dedicated understanding at 20 mechanistic level [5][6][7][8]. editorial, we feature collection recent articles focused further 21 developing our and/or biological underpinnings learning. 22In collection's first paper, de Groot et al. assessed human participants their reliance 23 utilized magnetic resonance imaging (MRI) calculate total volumes various 24 brain regions. Using machine models, they attempted determine whether volume 25 different regions related degree socially acquired information. They 26 found that increased thought be coming from another individual 27 decision making was higher pars triangularis entorhinal cortex. 28 also negative correlation activity certain 29 frontal post-central gyri. While authors speculated postcentral 30 gyri were more likely mediating visual processes required task performance, 31 uniquely involved 32In methods Taggert describe development an open-source automated 33 interaction chamber study threat mice. Their device consists 34 small "social stimulus" chamberlarge enough house adult mouse -that can neatly slot into 35 standard modular fear conditioning chambers. A series infrared photobeams barrier 36 two chambers detect interactions stimulus test mouse, allowing shock delivery 37 timed interaction. demonstrate system successfully induces 38 learned avoidance mice shocked mouse. design 39 allows easy integration model any lab outfitted 40 Much about remain understood. 57The included represent some latest findings, methodological 58 advances, discussions may help elucidate topic. 59 1

Язык: Английский

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The prelimbic prefrontal cortex mediates the development of lasting social avoidance as a consequence of social threat conditioning

Neuropsychopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Язык: Английский

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From memory disorders to the development of depression: a system approach

Biosystems, Год журнала: 2025, Номер unknown, С. 105440 - 105440

Опубликована: Март 1, 2025

Язык: Английский

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Neural basis of collective social behavior during environmental challenge

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 19, 2024

ABSTRACT Humans and animals have a remarkable capacity to collectively coordinate their behavior respond environmental challenges. However, the underlying neurobiology remains poorly understood. Here, we found that groups of mice self-organize into huddles at cold ambient temperature during thermal challenge assay. We make active (self-initiated) passive (partner-initiated) decisions enter or exit huddle. Using microendoscopic calcium imaging, are encoded distinctly within dorsomedial prefrontal cortex (dmPFC). Silencing dmPFC activity in some reduced decision-making, but also induced compensatory increase by non-manipulated partners, conserving group’s overall huddle time. These findings reveal how collective is implemented neurobiological mechanisms meet homeostatic needs

Язык: Английский

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Impacts of social isolation stress in safety learning and the structure of defensive behavior during a spatial-based learning task involving thermal threat

Frontiers in Behavioral Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Дек. 10, 2024

Safety learning during threat and adversity is critical for behavioral adaptation, resiliency, survival. Using a novel mouse paradigm involving thermal threat, we recently demonstrated that safety highly susceptible to social isolation stress. Yet, our previous study primarily considered male mice did not thoroughly scrutinize the relative impacts of stress on potentially distinct defensive mechanisms implemented by males females task. The present assessed these issues while considering variety behaviors related safety-seeking, escape, coping, protection, ambivalence, risk-taking. After two-week period, were required explore box arena had zones (5 vs. 30°C, respectively). Since visuospatial cues clearly differentiated zones, majority no-stress controls (69–75%) in both sexes exhibited optimal memory formation zone. In contrast, stress-exposed robust impairment Furthermore, control groups many correlations among various behaviors, disorganized behaviors. Thus, severely impaired proper establishment structure behavior, effects occurred sex-independent manner.

Язык: Английский

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The prelimbic prefrontal cortex mediates the development of lasting social phobia as a consequence of social threat conditioning.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 5, 2024

Abstract Social phobia is highly detrimental for social behavior, mental health, and productivity. Despite much previous research, the behavioral neurobiological mechanisms associated with development of remain elusive. To investigate these issues, present study implemented a mouse model threat conditioning in which mice received electric shock punishment upon interactions unfamiliar conspecifics. This resulted immediate reductions behavior robust increases defensive such as avoidance, freezing, darting, ambivalent stretched posture. Furthermore, deficits lasted prolonged periods were independent contextual settings, sex variables, or particular identity stimuli. Shedding new light into factors contributing to this phenomenon, we found that optogenetic silencing prelimbic (PL), but not infralimbic (IL), subregion medial prefrontal cortex (mPFC) during training led subsequent forgetting lasting phobia. Similarly, pharmacological inhibition NMDARs PL also impaired These findings are consistent notion social-related trauma prominent risk factor phobia, phenomenon engages learning-related within promote representations threat. Figure

Язык: Английский

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