Efficacy of Different Acupuncture Techniques for Pain and Dysfunction in Patients with Knee Osteoarthritis: A Randomized Controlled Trial
Pain and Therapy,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 17, 2025
Various
acupuncture
techniques
are
widely
applied
in
clinics
for
pain
control
and
dysfunction
relief
patients
with
knee
osteoarthritis
(KOA).
The
purpose
of
this
trial
was
to
investigate
whether
the
different
were
more
effective
treating
joint
than
sham
or
drug
treatment
KOA
determine
differences
efficacy
among
them.
In
multi-center,
single-blind,
randomized,
controlled
trial,
participants
randomly
assigned
manual
(MA),
electroacupuncture
(EA),
warm-needling
(WA),
mild
moxibustion
(MM),
(SA),
(Celebrex)
groups.
Each
participant
above
groups
received
individual
treatments
4
consecutive
weeks.
primary
outcome
measures
included
visual
analog
scale
score
(VAS)
physical
function
Western
Ontario
McMaster
Universities
Osteoarthritis
Index
(WOMAC).
Compared
SA
group,
technique
(MA,
EA,
WA,
MM)
had
markedly
lower
patient
VAS
scores
(−
0.61;
95%
CI
−
1.09
0.13;
P
=
0.01)
WOMAC
13.84;
21.14
6.54;
<
0.01).
Celebrex,
EA
a
significant
advantage
reducing
(1.14;
0.55
1.72;
(14.81;
5.69
23.93;
observed
effectively
relieve
ameliorate
KOA.
is
most
method
alleviating
intensity
registered
on
ClinicalTrials.gov
(NCT03563690).
Chronic
functional
disability
main
symptoms
that
occur
decrease
their
quality
life.
As
non-pharmacological
treatment,
acupuncture,
traditional
complementary
therapy
originating
China,
an
addressing
knee-related
disorders
clinic.
However,
efficiency
various
diseases
different.
at
controlling
experienced
treatments,
including
electroacupuncture,
moxibustion.
Celebrex.
We
measured
changes
perception
via
from
Index.
osteoarthritis.
compared
reported
intensity.
Moreover,
we
Celebrex
administration.
results
revealed
over
treatment.
This
finding
could
provide
sufficient
evidence
demonstrates
disparity
lead
proper
Язык: Английский
Electroacupuncture Regulates Sympathetic Nerve Through the NTSGlu‐RVLM Circuit to Relieve Spontaneous Pain in SNI Rats
CNS Neuroscience & Therapeutics,
Год журнала:
2025,
Номер
31(3)
Опубликована: Март 1, 2025
Patients
suffering
from
neuropathic
pain
often
experience
sympathetic
dysfunction.
Acupuncture
has
shown
promise
in
alleviating
and
modulating
the
activity
of
autonomic
nervous
system.
This
study
aims
to
explore
potential
mechanism
through
which
electroacupuncture
(EA)
modulates
nerves
alleviate
pain.
Spared
nerve
injury
(SNI)
was
utilized
induce
EA
administered
at
acupoints
Huantiao
Yanglingquan
for
30
min
every
other
day
after
SNI.
Pain
behavior
evaluated
using
paw
withdrawal
thresholds
(PWTs)
spontaneous
scores.
Various
techniques
including
immunofluorescence,
viral
tracing,
electrophysiology,
chemogenetic
manipulations
were
employed
investigate
impact
on
behaviors,
specifically
nucleus
tractus
solitarii
(NTS)Glu-rostral
ventrolateral
medulla
(RVLM)
circuit.
In
SNI
rats,
alleviated
both
mechanical
pain,
diminished
excitability,
inhibited
sprouting
within
dorsal
root
ganglia
(DRG),
reduced
excitability
glutamatergic
neurons
NTS
project
RVLM.
Chemogenetic
inhibition
NTSGlu-RVLM
circuit
produced
same
effect
as
extracellular
discharge
frequency
RVLM,
but
not
Similarly,
activation
negated
analgesic
effects
while
affecting
suggested
that
alleviates
rather
than
by
regulating
via
Язык: Английский
The analgesic mechanism of electroacupuncture at the central level for neuropathic pain: a review of studies based on animal experiments
Frontiers in Neurology,
Год журнала:
2025,
Номер
16
Опубликована: Май 29, 2025
This
article
analyzes
the
progress
of
animal
experiments
on
analgesic
mechanism
electroacupuncture
(EA)
at
central
level
for
neuropathic
pain
(NP)
in
past
10
years,
and
summarizes
EA
NP.
EA,
as
a
safe
reliable
treatment,
can
treat
NP
by
regulating
release
nociceptive
neurotransmitters
receptors,
upregulating
expression
non-coding
RNA
(ncRNA),
inhibiting
activation
microglia,
Ca
2+
/calmodulin
kinase
II
(CaMKII)
phosphorylation,
dendritic
spine
remodeling,
endoplasmic
reticulum
stress
(ERS),
glucose
metabolism.
is
type
caused
various
diseases.
Pain
stroke,
spinal
cord
injury,
postherpetic
neuralgia
(PHN),
diabetes,
chemotherapy-induced
neuropathy
all
fall
into
category
NP,
which
makes
treatment
very
challenging.
At
present,
research
more
focused
dorsal
horn
cord,
there
are
relatively
few
brain
region.
There
also
lack
clinical
trials
using
human
subjects
relevant
biochemical
indicators.
In
future,
electrophysiology,
neuron
tracing,
multi-omics
techniques
combined
with
emerging
technologies
such
artificial
intelligence
should
be
used
to
further
improve
making
best
Язык: Английский
Machine learning and confirmatory factor analysis show that buprenorphine alters motor and anxiety-like behaviors in male, female, and obese C57BL/6J mice
Journal of Neurophysiology,
Год журнала:
2024,
Номер
133(2), С. 502 - 512
Опубликована: Дек. 31, 2024
Machine
learning
and
pose
estimation
using
a
convolutional
neural
network
accurately
detected
objectively
scored
buprenorphine-induced
changes
in
locomotor
behaviors
of
mice
on
an
elevated
zero
maze
(EZM).
Confirmatory
factor
analysis
supports
the
interpretation
that
anxiety-like
construct
accounted
for
motor
behavior.
The
results
have
noteworthy
implications
relationship
between
Darwin’s
story
model
mammalian
emotions
computational
models
behavior
mice.
Язык: Английский