Role of Posterior Medial Thalamus in the Modulation of Striatal Circuitry and Choice Behavior
Опубликована: Янв. 6, 2025
The
posterior
medial
(POm)
thalamus
is
heavily
interconnected
with
sensory
and
motor
circuitry
likely
involved
in
behavioral
modulation
sensorimotor
integration.
POm
provides
axonal
projections
to
the
dorsal
striatum,
a
hotspot
of
processing,
yet
role
POm-striatal
has
remained
undetermined.
Using
optogenetics
slice
electrophysiology,
we
found
that
robust
synaptic
input
direct
indirect
pathway
striatal
spiny
projection
neurons
(D1-
D2-SPNs,
respectively)
parvalbumin-expressing
fast
spiking
interneurons
(PVs).
During
performance
whisker-based
tactile
discrimination
task,
displayed
learning-related
activation
correlating
anticipatory,
but
not
reward-related,
pupil
dilation.
Inhibition
axons
across
learning
caused
slower
reaction
times
an
increase
number
training
sessions
for
expert
performance.
Our
data
indicate
inputs
provide
behaviorally
relevant
arousal-related
signal,
which
may
prime
efficient
integration
subsequent
choice-related
inputs.
Язык: Английский
Local, calcium- and reward-based synaptic learning rule that enhances dendritic nonlinearities can solve the nonlinear feature binding problem
Опубликована: Апрель 24, 2025
This
study
investigates
the
computational
potential
of
single
striatal
projection
neurons
(SPN),
emphasizing
dendritic
nonlinearities
and
their
crucial
role
in
solving
complex
integration
problems.
Utilizing
a
biophysically
detailed
multicompartmental
model
an
SPN,
we
introduce
calcium-based,
local
synaptic
learning
rule
dependent
on
plateau
potentials.
According
to
what
is
known
about
excitatory
corticostriatal
synapses,
governed
by
calcium
dynamics
from
NMDA
L-type
channels
dopaminergic
reward
signals.
In
order
devise
self-adjusting
rule,
which
ensures
stability
for
individual
weights,
metaplasticity
also
used.
We
demonstrate
that
this
allows
solve
nonlinear
feature
binding
problem,
task
traditionally
attributed
neuronal
networks.
detail
inhibitory
plasticity
mechanism
contributes
compartmentalization,
further
enhancing
efficiency
dendrites.
silico
highlights
neurons,
providing
deeper
insights
into
information
processing
mechanisms
brain
executes
computations.
Язык: Английский
An Open-Source Joystick Platform for Investigating Forelimb Motor Control, Auditory-Motor Integration, and Value-Based Decision-Making in Head-Fixed Mice
eNeuro,
Год журнала:
2025,
Номер
12(4), С. ENEURO.0038 - 25.2025
Опубликована: Апрель 1, 2025
Investigation
of
neural
processes
underlying
motor
control
requires
behavioral
readouts
that
capture
the
richness
actions,
including
both
categorical
(choice-based)
information
and
execution
(kinematics).
We
present
an
open-source
platform
for
training
head-fixed
mice
combines
a
stationary
or
retractable
forelimb-based
joystick,
sound-presentation
system,
capacitive
lick
sensor,
water
reward
dispenser.
The
setup
allows
creation
multiple
paradigms,
two
which
are
highlighted
here:
two-alternative
forced-choice
auditory-motor
discrimination
paradigm
two-armed
bandit
value-based
decision-making
task.
In
paradigm,
learn
to
report
high-
low-frequency
tones
by
pushing
pulling
joystick.
push
pull
joystick
based
on
history
rewarded
trials.
addition
reporting
choices,
this
provides
rich
dataset
parameters
reflect
components
learning
decision
in
these
tasks.
These
kinematic
(including
speed
displacement,
Fréchet
similarity
trajectories,
tortuosity,
angular
standard
deviation,
movement
vigor)
provide
key
additional
insights
into
choices
not
as
readily
assessed
other
paradigms.
system's
flexibility
task
design,
readout,
ease
construction
represent
advance
compared
with
currently
available
manipulandum
tasks
mice.
detailed
schematics
constructing
protocols
using
hope
resource
is
adopted
neuroscientists
interested
mechanisms
sensorimotor
integration,
control,
choice
behavior.
Язык: Английский
Role of posterior medial thalamus in the modulation of striatal circuitry and choice behavior
eLife,
Год журнала:
2025,
Номер
13
Опубликована: Май 13, 2025
The
posterior
medial
(POm)
thalamus
is
heavily
interconnected
with
sensory
and
motor
circuitry
likely
involved
in
behavioral
modulation
sensorimotor
integration.
POm
provides
axonal
projections
to
the
dorsal
striatum,
a
hotspot
of
processing,
yet
role
POm-striatal
has
remained
undetermined.
Using
optogenetics
mouse
brain
slice
electrophysiology,
we
found
that
robust
synaptic
input
direct
indirect
pathway
striatal
spiny
projection
neurons
(D1-
D2-SPNs,
respectively)
parvalbumin-expressing
fast
spiking
interneurons
(PVs).
During
performance
whisker-based
tactile
discrimination
task
head-restrained
mice,
displayed
learning-related
activation
correlating
anticipatory,
but
not
reward-related,
pupil
dilation.
Inhibition
axons
across
learning
caused
slower
reaction
times
an
increase
number
training
sessions
for
expert
performance.
Our
data
indicate
inputs
provide
behaviorally
relevant
arousal-related
signal,
which
may
prime
efficient
integration
subsequent
choice-related
inputs.
Язык: Английский
Local, calcium- and reward-based synaptic learning rule that enhances dendritic nonlinearities can solve the nonlinear feature binding problem
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 14, 2024
Abstract
This
study
explores
the
computational
potential
of
single
striatal
projection
neurons
(SPN),
emphasizing
dendritic
nonlinearities
and
their
crucial
role
in
solving
complex
integration
problems.
Utilizing
a
biophysically
detailed
multicompartmental
model
an
SPN,
we
introduce
calcium-based,
local
synaptic
learning
rule
that
leverages
plateau
potentials.
According
to
what
is
known
about
excitatory
corticostriatal
synapses,
governed
by
calcium
dynamics
from
NMDA
L-type
channels
dopaminergic
reward
signals.
In
addition,
incorporated
metaplasticity
order
devise
self-adjusting
which
ensures
stability
for
individual
weights.
We
demonstrate
this
allows
solve
nonlinear
feature
binding
problem
(NFBP),
task
traditionally
attributed
neuronal
networks.
also
detail
inhibitory
plasticity
mechanism,
critical
compartmentalization,
further
enhancing
efficiency
dendrites.
silico
underscores
capacity
neurons,
extending
our
understanding
processing
brain’s
ability
perform
computations.
Язык: Английский
Role of Posterior Medial Thalamus in the Modulation of Striatal Circuitry and Choice Behavior
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 27, 2024
Summary
The
posterior
medial
(POm)
thalamus
is
heavily
interconnected
with
sensory
and
motor
circuitry
likely
involved
in
behavioral
modulation
sensorimotor
integration.
POm
provides
axonal
projections
to
the
dorsal
striatum,
a
hotspot
of
processing,
yet
role
POm-striatal
has
remained
undetermined.
Using
optogenetics
slice
electrophysiology,
we
found
that
robust
synaptic
input
direct
indirect
pathway
striatal
spiny
projection
neurons
(D1-
D2-SPNs,
respectively)
parvalbumin-expressing
fast
spiking
interneurons
(PVs).
During
performance
whisker-based
tactile
discrimination
task,
displayed
learning-related
activation
correlating
anticipatory,
but
not
reward-related,
pupil
dilation.
Inhibition
axons
across
learning
caused
slower
reaction
times
an
increase
number
training
sessions
for
expert
performance.
Our
data
indicate
inputs
provide
behaviorally
relevant
arousal-related
signal,
which
may
prime
efficient
integration
subsequent
choice-related
inputs.
Язык: Английский
Local, calcium- and reward-based synaptic learning rule that enhances dendritic nonlinearities can solve the nonlinear feature binding problem
Опубликована: Июнь 17, 2024
This
study
explores
the
computational
potential
of
single
striatal
projection
neurons
(SPN),
emphasizing
dendritic
nonlinearities
and
their
crucial
role
in
solving
complex
integration
problems.
Utilizing
a
biophysically
detailed
multicompartmental
model
an
SPN,
we
introduce
calcium-based,
local
synaptic
learning
rule
that
leverages
plateau
potentials.
According
to
what
is
known
about
excitatory
corticostriatal
synapses,
governed
by
calcium
dynamics
from
NMDA
L-type
channels
dopaminergic
reward
signals.
In
addition,
incorporated
metaplasticity
order
devise
self-adjusting
which
ensures
stability
for
individual
weights.
We
demonstrate
this
allows
solve
nonlinear
feature
binding
problem
(NFBP),
task
traditionally
attributed
neuronal
networks.
also
detail
inhibitory
plasticity
mechanism,
critical
compartmentalization,
further
enhancing
efficiency
dendrites.
silico
underscores
capacity
neurons,
extending
our
understanding
processing
brain’s
ability
perform
computations.
Язык: Английский
Local, calcium- and reward-based synaptic learning rule that enhances dendritic nonlinearities can solve the nonlinear feature binding problem
Опубликована: Июнь 17, 2024
This
study
explores
the
computational
potential
of
single
striatal
projection
neurons
(SPN),
emphasizing
dendritic
nonlinearities
and
their
crucial
role
in
solving
complex
integration
problems.
Utilizing
a
biophysically
detailed
multicompartmental
model
an
SPN,
we
introduce
calcium-based,
local
synaptic
learning
rule
that
leverages
plateau
potentials.
According
to
what
is
known
about
excitatory
corticostriatal
synapses,
governed
by
calcium
dynamics
from
NMDA
L-type
channels
dopaminergic
reward
signals.
In
addition,
incorporated
metaplasticity
order
devise
self-adjusting
which
ensures
stability
for
individual
weights.
We
demonstrate
this
allows
solve
nonlinear
feature
binding
problem
(NFBP),
task
traditionally
attributed
neuronal
networks.
also
detail
inhibitory
plasticity
mechanism,
critical
compartmentalization,
further
enhancing
efficiency
dendrites.
silico
underscores
capacity
neurons,
extending
our
understanding
processing
brain’s
ability
perform
computations.
Язык: Английский
Role of Posterior Medial Thalamus in the Modulation of Striatal Circuitry and Choice Behavior
Опубликована: Июль 8, 2024
The
posterior
medial
(POm)
thalamus
is
heavily
interconnected
with
sensory
and
motor
circuitry
likely
involved
in
behavioral
modulation
sensorimotor
integration.
POm
provides
axonal
projections
to
the
dorsal
striatum,
a
hotspot
of
processing,
yet
role
POm-striatal
has
remained
undetermined.
Using
optogenetics
slice
electrophysiology,
we
found
that
robust
synaptic
input
direct
indirect
pathway
striatal
spiny
projection
neurons
(D1-
D2-SPNs,
respectively)
parvalbumin-expressing
fast
spiking
interneurons
(PVs).
During
performance
whisker-based
tactile
discrimination
task,
displayed
learning-related
activation
correlating
anticipatory,
but
not
reward-related,
pupil
dilation.
Inhibition
axons
across
learning
caused
slower
reaction
times
an
increase
number
training
sessions
for
expert
performance.
Our
data
indicate
inputs
provide
behaviorally
relevant
arousal-related
signal,
which
may
prime
efficient
integration
subsequent
choice-related
inputs.
Язык: Английский
Role of Posterior Medial Thalamus in the Modulation of Striatal Circuitry and Choice Behavior
Опубликована: Июль 8, 2024
The
posterior
medial
(POm)
thalamus
is
heavily
interconnected
with
sensory
and
motor
circuitry
likely
involved
in
behavioral
modulation
sensorimotor
integration.
POm
provides
axonal
projections
to
the
dorsal
striatum,
a
hotspot
of
processing,
yet
role
POm-striatal
has
remained
undetermined.
Using
optogenetics
slice
electrophysiology,
we
found
that
robust
synaptic
input
direct
indirect
pathway
striatal
spiny
projection
neurons
(D1-
D2-SPNs,
respectively)
parvalbumin-expressing
fast
spiking
interneurons
(PVs).
During
performance
whisker-based
tactile
discrimination
task,
displayed
learning-related
activation
correlating
anticipatory,
but
not
reward-related,
pupil
dilation.
Inhibition
axons
across
learning
caused
slower
reaction
times
an
increase
number
training
sessions
for
expert
performance.
Our
data
indicate
inputs
provide
behaviorally
relevant
arousal-related
signal,
which
may
prime
efficient
integration
subsequent
choice-related
inputs.
Язык: Английский