Retinal neurochemistry; metabolic effects of epilepsy-linked genes; LAMP1 protein DOI Open Access

Jill Adams

The Transmitter, Год журнала: 2023, Номер unknown

Опубликована: Янв. 1, 2023

Scientists are increasingly proposing measures of retinal neurochemistry as biomarkers clinical conditions, including autism, attention-deficit/hyperactivity disorder and schizophrenia.Frontiers in Neuroscience Autistic children have lower blood levels the protein ADAM8 than non-autistic do, according to a small study.Neuropsychiatric Disease Treatment toddlers show altered neural responses human speech.Journal Online surveys susceptible fraudulent responses, but there ways identify prevent such fakes.Spectrum reported on various efforts flag online survey fraud last week.PLOS Global Public Health people better at interpreting behavior an autistic person workplace setting.Autism Adulthood The National Association for Biomedical Research is challenging conservation group's determination that long-tailed macaques, primate commonly used research, endangered.Science Variants genes -such SCN1A KCNA1 -that affect ion channels cause epilepsy appear bring about metabolic changes contribute seizure activity, review.Journal Neurochemistry Non-cancer therapies genetic conditions take average 25 years develop -from identification target government approval treatment.Nature Frequency change: (top row) (bottom different EEG activity response natural speech.

Язык: Английский

Neuroplasticity of children in autism spectrum disorder DOI Creative Commons
Zilin Chen,

Xu Wang,

Si Zhang

и другие.

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Апрель 25, 2024

Autism spectrum disorder (ASD) is a neurodevelopmental that encompasses range of symptoms including difficulties in verbal communication, social interaction, limited interests, and repetitive behaviors. Neuroplasticity refers to the structural functional changes occur nervous system adapt respond external environment. In simpler terms, it brain's ability learn new environments. However, individuals with ASD exhibit abnormal neuroplasticity, which impacts information processing, sensory cognition, leading manifestation corresponding symptoms. This paper aims review current research progress on focusing genetics, environment, neural pathways, neuroinflammation, immunity. The findings will provide theoretical foundation insights for intervention treatment pediatric fields related ASD.

Язык: Английский

Процитировано

6
The relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives DOI Creative Commons
Vardan Arutiunian,

Megha Santhosh,

Emily Neuhaus

и другие.

Molecular Autism, Год журнала: 2024, Номер 15(1)

Опубликована: Май 7, 2024

Abstract Background Most children with Autism Spectrum Disorder (ASD) have co-occurring language impairments and some of these autism-specific difficulties are also present in their non-autistic first-degree relatives. One the possible neural mechanisms associated variability functioning is alterations cortical gamma-band oscillations, hypothesized to be related excitation inhibition balance. Methods We used a high-density 128-channel electroencephalography (EEG) register brain response speech stimuli large sex-balanced sample participants: 125 youth ASD, 121 typically developing (TD) youth, 40 unaffected siblings (US) ASD. Language skills were assessed Clinical Evaluation Fundamentals. Results First, during processing, we identified significantly elevated gamma power ASD participants compared TD controls. Second, across all higher was lower skills. Finally, US group demonstrated an intermediate profile both power, nonverbal IQ mediating relationship between Limitations only focused on one contributors functioning. Also, consisted smaller number comparison or groups. due timing issue EEG system provided non-phase-locked analysis. Conclusions Autistic showed suggesting The pattern activity, that broader autism phenotype extends profiles.

Язык: Английский

Процитировано

4
Atypical audio-visual neural synchrony and speech processing in early autism DOI Creative Commons
Xiaoyue Wang, Sophie Bouton, Nada Kojovic

и другие.

Journal of Neurodevelopmental Disorders, Год журнала: 2025, Номер 17(1)

Опубликована: Фев. 18, 2025

Abstract Background Children with Autism Spectrum disorder (ASD) often exhibit communication difficulties that may stem from basic auditory temporal integration impairment but also be aggravated by an audio-visual deficit, resulting in a lack of interest face-to-face communication. This study addresses whether speech processing anomalies young autistic children (mean age 3.09-year-old) are associated alterations integration. Methods We used high-density electroencephalography (HD-EEG) and eye tracking to record brain activity gaze patterns 31 ASD (6 females) 33 typically developing (TD) (11 females), while they watched cartoon videos. Neural responses stimuli were analyzed using Temporal Response Functions model phase analyses for audiovisual coordination. Results The reconstructability signals was reduced compared TD, despite more restricted it similar visual both groups. Speech reception most strongly affected when information present, interference not seen TD children. These differences broader angle distribution (exceeding pi/2) the EEG theta range ASD, signaling reliability alignment. Conclusion findings show do stand alone already at very early development stage imbalance poor response encoding disrupted

Язык: Английский

Процитировано

0
Atypical Audio-Visual Neural Synchrony and Speech Processing in children with Autism Spectrum Disorder DOI Creative Commons
Xiaoyue Wang, Sophie Bouton, Nada Kojovic

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 19, 2024

Background: Children with Autism Spectrum Disorders (ASD) often exhibit communication difficulties that may stem from basic auditory temporal integration impairment but also be aggravated by an audio-visual deficit, resulting in a lack of interest face-to-face communication. This study addresses whether speech processing anomalies young (mean age 3.09-year-old) children ASD are associated alterations integration. Methods: We used high-density electroencephalography (HD-EEG) and eye tracking to record brain activity gaze patterns 31 (6 females) 33 typically developing (TD) (11 females), while they watched cartoon videos. Neural responses stimuli were analyzed using Temporal Response Functions model phase analyses for audiovisual coordination. Results: The reconstructability signals was reduced compared controls, despite more restricted it similar visual both groups. Speech reception most strongly affected when information present, interference not seen TD children. These differences broader angle distribution (exceeding pi/2) the EEG theta range autistic children, signaling reliability alignment. Conclusion: findings show do stand alone already at very early development stage imbalance lousier response encoding disrupted

Язык: Английский

Процитировано

1
Altered neural synchronization in response to 2 Hz tones in the auditory cortex of children with ASD: An MEG study DOI

Ilya Samoylov,

Giorgio Arcara,

Irina Buyanova

и другие.

International Journal of Psychophysiology, Год журнала: 2024, Номер 203, С. 112405 - 112405

Опубликована: Июль 23, 2024

Язык: Английский

Процитировано

1
On the Role of Neural Oscillations Across Timescales in Speech and Music Processing DOI Creative Commons
G. Nike Gnanateja, Dhatri S. Devaraju,

Matthias Heyne

и другие.

Frontiers in Computational Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Июнь 23, 2022

This mini review is aimed at a clinician-scientist seeking to understand the role of oscillations in neural processing and their functional relevance speech music perception. We present an overview oscillations, methods used study them, with respect processing, aging, hearing loss, disorders affecting language. first oscillatory frequency bands associations processing. Next we describe commonly metrics for quantifying briefly touching upon still-debated mechanisms underpinning alignment. Following this, highlight key findings from research on perception, as well contributions this work our understanding disordered perception clinical populations. Finally, conclude look toward future including promising potential avenues work. note that intention not systematically all literature cortical tracking music. Rather, seek provide foundational information can be evaluate design studies targeting typical

Язык: Английский

Процитировано

6
Retinal neurochemistry; metabolic effects of epilepsy-linked genes; LAMP1 protein DOI Open Access

Jill Adams

The Transmitter, Год журнала: 2023, Номер unknown

Опубликована: Янв. 1, 2023

Scientists are increasingly proposing measures of retinal neurochemistry as biomarkers clinical conditions, including autism, attention-deficit/hyperactivity disorder and schizophrenia.Frontiers in Neuroscience Autistic children have lower blood levels the protein ADAM8 than non-autistic do, according to a small study.Neuropsychiatric Disease Treatment toddlers show altered neural responses human speech.Journal Online surveys susceptible fraudulent responses, but there ways identify prevent such fakes.Spectrum reported on various efforts flag online survey fraud last week.PLOS Global Public Health people better at interpreting behavior an autistic person workplace setting.Autism Adulthood The National Association for Biomedical Research is challenging conservation group's determination that long-tailed macaques, primate commonly used research, endangered.Science Variants genes -such SCN1A KCNA1 -that affect ion channels cause epilepsy appear bring about metabolic changes contribute seizure activity, review.Journal Neurochemistry Non-cancer therapies genetic conditions take average 25 years develop -from identification target government approval treatment.Nature Frequency change: (top row) (bottom different EEG activity response natural speech.

Язык: Английский

Процитировано

0