Radiotherapy and Oncology,
Год журнала:
2021,
Номер
160, С. 259 - 265
Опубликована: Май 18, 2021
To
update
the
digital
online
atlas
for
organs
at
risk
(OARs)
delineation
in
neuro-oncology
based
on
high-quality
computed
tomography
(CT)
and
magnetic
resonance
(MR)
imaging
with
new
OARs.In
this
planned
of
neurological
contouring
published
2018,
ten
clinically
relevant
OARs
were
included,
after
thorough
discussion
between
experienced
neuro-radiation
oncologists
(RTOs)
representing
30
European
radiotherapy-oncology
institutes.
Inclusion
was
daily
practice
research
requirements.
Consensus
reached
critical
review.
Contouring
performed
registered
CT
intravenous
(IV)
contrast
(soft
tissue
&
bone
window
setting)
3
Tesla
(T)
MRI
(T1
gadolinium
T2
FLAIR)
images
one
patient
(1
mm
slices).
For
illustration
purposes,
a
7
T
without
IV
from
healthy
volunteer
added.
delineated
by
three
RTOs
neuroradiologist
literature.The
presented
reviewed
approved
28
experts
field.
The
is
available
includes
total
25
to
neuro-oncology,
contoured
T1
FLAIR
(3
T).
Three-dimensional
(3D)
rendered
films
are
also
online.In
order
further
decrease
inter-
intra-observer
OAR
variability
field
we
propose
use
photon
particle
therapy,
clinical
setting.
updated
freely
www.cancerdata.org.
Journal of Neuroinflammation,
Год журнала:
2022,
Номер
19(1)
Опубликована: Апрель 4, 2022
Poststroke
cognitive
impairment
(PSCI)
is
prevalent
in
stroke
patients.
The
etiology
of
PSCI
remains
largely
unknown.
We
previously
found
that
induces
gut
microbiota
dysbiosis
which
affects
brain
injury.
Hereby,
we
aimed
to
investigate
whether
the
contributes
pathogenesis
PSCI.83
patients
were
recruited
and
their
function
measured
by
Montreal
Cognitive
Assessment
(MoCA)
scores
3
months
after
onset.
peripheral
inflammatory
factor
levels
compositions
analyzed.
Fecal
transplantation
from
mice
was
performed
examine
causal
relationship
between
PSCI.
evaluated
Morris
water
maze
test.34
49
classified
as
non-PSCI,
respectively.
Compared
with
non-PSCI
patients,
showed
significantly
higher
Enterobacteriaceae,
lipopolysaccharide
(LPS)
inflammation
markers.
Consistently,
received
(PSCI
mice)
presented
a
level
intestinal
Toll-like
receptor-4
(TLR4)
expression,
circulating
LPS,
LPS-binding
protein
(LBP)
cytokines,
lower
fecal
butyrate,
severer
intestine
destruction
than
nPSCI
(nPSCI
mice).
In
addition,
observed
exacerbations
blood-brain
barrier
(BBB)
integrity,
microglial
activation,
neuronal
apoptosis
CA1
region
hippocampus,
Aβ
deposition
thalamus
comparison
mice.
Intraperitoneal
injection
LPS
caused
similar
pathology
those
seen
Supplementation
sodium
butyrate
(NaB)
via
drinking
rescued
these
detrimental
changes
mice.Our
data
indicate
cause-effect
for
first
time,
likely
mediated
inflammation-regulating
metabolites
including
butyrate.
Cell Reports,
Год журнала:
2023,
Номер
42(2), С. 112118 - 112118
Опубликована: Фев. 1, 2023
The
claustrum
(CLA)
is
a
conspicuous
subcortical
structure
interconnected
with
cortical
and
regions.
Its
regional
anatomy
cell-type-specific
connections
in
the
mouse
remain
not
fully
determined.
Using
multimodal
reference
datasets,
we
confirmed
delineation
of
CLA
as
single
group
neurons
embedded
agranular
insular
cortex.
We
quantitatively
investigated
brain-wide
inputs
outputs
using
bulk
anterograde
retrograde
viral
tracing
data
neuron
data.
found
that
prefrontal
module
has
more
cell
types
projecting
to
than
other
modules,
layer
5
IT
predominating.
nine
morphological
principal
topographically
innervate
functionally
linked
targets,
preferentially
midline
areas,
secondary
motor
area,
entorhinal
area.
Together,
this
study
provides
detailed
wiring
diagram
CLA,
laying
foundation
for
studying
its
functions
at
cellular
level.
