Local Sleep and Alzheimer’s Disease Pathophysiology DOI Creative Commons
Bryce A. Mander

Frontiers in Neuroscience, Год журнала: 2020, Номер 14

Опубликована: Сен. 23, 2020

Even prior to the onset of prodromal stages Alzheimer's disease (AD), a constellation sleep disturbances are apparent. A series epidemiological studies indicate that multiple forms these associated with increased risk for developing mild cognitive impairment (MCI) and AD, even triggering at an earlier age. Through combination causal manipulation in humans rodents, as well targeted examination disturbance respect AD biomarkers, mechanisms linking beginning emerge. In this review, we explore recent evidence local deficits brain oscillatory function during pathological burden circuit-level dysfunction degeneration. short, three expression oscillations have been identified relation pathophysiology: 1) frequency-specific frontal slow wave non-rapid eye movement (NREM) sleep, 2) parietal spindle expression, 3) quality electroencephalographic (EEG) desynchrony characteristic REM sleep. These noteworthy since they differ from seen normal aging, indicating potential presence abnormal aging process. How each β-amyloid (Aβ) tau pathology, neurodegeneration circuits sensitive pathophysiology, examined present focus on role within fronto-hippocampal subcortical sleep-wake circuits. It is hypothesized arise distinct network-specific dysfunctions driven by regionally-specific accumulation pathologies, their neurodegeneration. Overall, evolution offer unique windows into circuit-specific progression pathophysiological processes onset, impact function. This includes erosion sleep-dependent memory mechanisms, which may contribute decline AD. review closes discussion remaining critical knowledge gaps implications work future mechanistic implementing sleep-based treatment interventions.

Язык: Английский

Bidirectional relationship between sleep and Alzheimer’s disease: role of amyloid, tau, and other factors DOI Open Access
Chanung Wang, David M. Holtzman

Neuropsychopharmacology, Год журнала: 2019, Номер 45(1), С. 104 - 120

Опубликована: Авг. 13, 2019

Язык: Английский

Процитировано

435
Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans DOI Creative Commons
Randolph F. Helfrich, Janna D. Lendner, Bryce A. Mander

и другие.

Nature Communications, Год журнала: 2019, Номер 10(1)

Опубликована: Авг. 8, 2019

How are memories transferred from short-term to long-term storage? Systems-level memory consolidation is thought be dependent on the coordinated interplay of cortical slow waves, thalamo-cortical sleep spindles and hippocampal ripple oscillations. However, it currently unclear how selective interaction these cardinal oscillations organized support information reactivation transfer. Here, using human intracranial recordings, we demonstrate that prefrontal cortex plays a key role in organizing ripple-mediated transfer during non-rapid eye movement (NREM) sleep. We reveal temporally precise form coupling between slow-wave spindle oscillations, which actively dictates hippocampal-neocortical dialogue Our results suggest model sleeping brain rapid bidirectional interactions, triggered by cortex, mediate activation optimally time subsequent neocortex NREM

Язык: Английский

Процитировано

205
Sleep Disturbance Forecasts β-Amyloid Accumulation across Subsequent Years DOI Creative Commons
Joseph R. Winer, Bryce A. Mander,

Samika Kumar

и другие.

Current Biology, Год журнала: 2020, Номер 30(21), С. 4291 - 4298.e3

Опубликована: Сен. 3, 2020

Язык: Английский

Процитировано

152
Anti-amyloid antibody therapies in Alzheimer’s disease DOI
Robert Perneczky, Frank Jessen, Timo Grimmer

и другие.

Brain, Год журнала: 2023, Номер 146(3), С. 842 - 849

Опубликована: Янв. 19, 2023

After years of failed attempts to develop a disease-modifying therapy for Alzheimer's disease, consistent evidence in support clinical efficacy was finally presented monoclonal antibody targeting the amyloid-β protofibrils. In addition meeting primary outcome slowing disease progression over 18 months, secondary outcomes and lowering on PET also underpin positive results trial. this opinion piece, we highlight key characteristics previous unsuccessful trials analyse potential reasons why those treatment early failed. We compare safety profiles different antibodies cautionary measures their routine use. Last, discuss role blood-based biomarkers transforming care pathway facilitate uptake treatments, proposing an integrated case-finding model crossing healthcare sectors. Taken together, real breakthrough may have been achieved by proving that reduction benefits, rather than just biomarker changes. At same time, use new generation drugs will show if statistical translates into clinically meaningful change. This be beginning era drug development.

Язык: Английский

Процитировано

122
Epilepsy and epileptiform activity in late-onset Alzheimer disease: clinical and pathophysiological advances, gaps and conundrums DOI
Anita Kamondi, Madeleine Grigg‐Damberger, Wolfgang Löscher

и другие.

Nature Reviews Neurology, Год журнала: 2024, Номер 20(3), С. 162 - 182

Опубликована: Фев. 14, 2024

Язык: Английский

Процитировано

33
Association of rapid eye movement sleep latency with multimodal biomarkers of Alzheimer's disease DOI Creative Commons
Jiangli Jin, Jiong Chen, Clémence Cavaillès

и другие.

Alzheimer s & Dementia, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Abstract INTRODUCTION Sleep disturbances are associated with Alzheimer's disease (AD) and related dementias (ADRD), but the relationship between sleep architecture, particularly rapid eye movement (REM) sleep, AD/ADRD biomarkers remains unclear. METHODS We enrolled 128 adults (64 disease, 41 mild cognitive impairment [MCI], 23 normal cognition [NC]), mean age 70.8 ± 9.6 years, 56.9% female, from a tertiary hospital in China. Participants underwent overnight polysomnography (PSG), amyloid β (Aβ) positron emission tomography (PET), plasma biomarker analysis: phosphorylated tau at threonine 181 (p‐tau181), neurofilament light (NfL), brain‐derived neurotrophic factor (BDNF). RESULTS After adjusting for demographics, apolipoprotein E ( APOE ) ε4 status, cognition, comorbidities, highest tertile of REM latency was higher Aβ burden = 0.08, 95% confidence interval [CI]: 0.03 to 0.13, p 0.002), elevated p‐tau181 0.19, CI: 0.02 reduced BDNF levels ‐0.47, –0.68 –0.13, 0.013), compared lowest tertile. DISCUSSION Prolonged may serve as novel marker or risk pathogenesis. Highlights Rapid (REML) be potential (AD/ADRD) REML beta burden, tau‐181 lower (BDNF) levels. Intervention trial is needed determine if targeting can modify risk. Slow‐wave not biomarkers.

Язык: Английский

Процитировано

3
Slow oscillation-spindle coupling predicts enhanced memory formation from childhood to adolescence DOI Creative Commons
Michael A Hahn, Dominik Philip Johannes Heib, Manuel Schabus

и другие.

eLife, Год журнала: 2020, Номер 9

Опубликована: Июнь 24, 2020

Precise temporal coordination of slow oscillations (SO) and sleep spindles is a fundamental mechanism sleep-dependent memory consolidation. SO spindle morphology changes considerably throughout development. Critically, it remains unknown how the precise these two develops during brain maturation whether their synchronization indexes development networks. Here, we use longitudinal study design spanning from childhood to adolescence, where participants underwent polysomnography performed declarative word-pair learning task. Performance on task was better adolescence. After disentangling oscillatory components 1/f activity, found frequency shifts within bands. Consequently, devised an individualized cross-frequency coupling approach, which demonstrates that SO-spindle strength increases maturation. this increase indicated enhanced formation Our results provide evidence improved between SOs

Язык: Английский

Процитировано

120
Macro and micro sleep architecture and cognitive performance in older adults DOI
Ina Djonlagic, Sara Mariani,

Annette L. Fitzpatrick

и другие.

Nature Human Behaviour, Год журнала: 2020, Номер 5(1), С. 123 - 145

Опубликована: Ноя. 16, 2020

Язык: Английский

Процитировано

119
It's complicated: The relationship between sleep and Alzheimer's disease in humans DOI Creative Commons
Brendan P. Lucey

Neurobiology of Disease, Год журнала: 2020, Номер 144, С. 105031 - 105031

Опубликована: Июль 29, 2020

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by an asymptomatic period of amyloid-β (Aβ) deposition as insoluble extracellular plaque, intracellular tau aggregation, neuronal and synaptic loss, subsequent cognitive dysfunction dementia. A growing public health crisis, the worldwide prevalence AD expected to rise from 46.8 million individuals affected in 2015 131.5 2050. Sleep disturbances have been associated with increased future risk AD. bi-directional relationship hypothesized between sleep either markers for pathology and/or mechanism mediating In this review, evidence humans supporting complex will be discussed well therapeutic potential challenges treating prevent or delay onset

Язык: Английский

Процитировано

110
Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer’s disease DOI Open Access
Brendan P. Lucey, Julie K. Wisch, Anna H. Boerwinkle

и другие.

Brain, Год журнала: 2021, Номер 144(9), С. 2852 - 2862

Опубликована: Июль 15, 2021

Sleep monitoring may provide markers for future Alzheimer's disease; however, the relationship between sleep and cognitive function in preclinical early symptomatic disease is not well understood. Multiple studies have associated short long times with impairment. Since risk of change age, a greater understanding how cognition changes over time needed. In this study, we hypothesized that longitudinal will non-linear total time, spent non-REM REM sleep, efficiency slow wave activity. To test hypothesis, monitored sleep-wake activity 4-6 nights 100 participants who underwent standardized testing longitudinally, APOE genotyping, measurement biomarkers, tau amyloid-β42 CSF. assess function, individuals completed neuropsychological battery at each clinical visit included Free Cued Selective Reminding test, Logical Memory Delayed Recall assessment, Digit Symbol Substitution Mini-Mental State Examination. Performance on these four tests was Z-scored within cohort averaged to calculate Alzheimer composite score. We estimated effect cross-sectional parameters performance using generalized additive mixed effects models. Generalized models allow non-parametric model fitting are simply linear models; predictors constant values but rather sum spline fits. found measured by decreased low high (P < 0.001), 0.001) 0.01) <1 Hz 1-4.5 even after adjusting CSF tau/amyloid-β42 ratio, ε4 carrier status, years education sex. Cognitive stable middle range activity, suggesting certain levels important maintaining function. Although interventional needed, diagnosing treating disturbances optimize stabilizing or disease.

Язык: Английский

Процитировано

103