Alzheimer s Research & Therapy,
Год журнала:
2020,
Номер
12(1)
Опубликована: Май 13, 2020
Abstract
Background
The
panel
of
fluid-
and
imaging-based
biomarkers
available
for
neurodegenerative
disease
research
is
growing
has
the
potential
to
close
important
gaps
in
clinic.
With
this
growth
increasing
use,
appropriate
implementation
interpretation
are
paramount.
Various
feature
nuanced
differences
strengths,
limitations,
biases
that
must
be
considered
when
investigating
etiology
clinical
utility.
For
example,
neuropathological
investigations
Alzheimer’s
pathogenesis
can
fall
disagreement
with
conclusions
reached
by
biomarker-based
investigations.
Considering
varied
different
methodologies
approaches
may
help
harmonize
disciplines
within
field.
Purpose
review
Along
separate
articles
covering
fluid
imaging
issue
Research
Therapy
,
we
present
result
a
discussion
from
2019
Biomarkers
Neurodegenerative
Diseases
course
at
University
College
London.
Here,
discuss
themes
biomarker
use
research,
commenting
on
interpretation,
considerations
across
diseases.
We
also
draw
attention
areas
where
combined
other
understand
issues
pathophysiology
underlying
dementia.
Lastly,
highlight
novel
modalities
have
been
proposed
landscape
care.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(4), С. 3221 - 3221
Опубликована: Фев. 6, 2023
Emerging
evidence
suggests
that
an
important
function
of
the
sleeping
brain
is
removal
wastes
and
toxins
from
central
nervous
system
(CNS)
due
to
activation
waste
(BWRS).
The
meningeal
lymphatic
vessels
(MLVs)
are
part
BWRS.
A
decrease
in
MLV
associated
with
Alzheimer’s
Parkinson’s
diseases,
intracranial
hemorrhages,
tumors
trauma.
Since
BWRS
activated
during
sleep,
a
new
idea
now
being
actively
discussed
scientific
community:
night
stimulation
might
be
innovative
promising
strategy
for
neurorehabilitation
medicine.
This
review
highlights
trends
photobiomodulation
BWRS/MLVs
deep
sleep
as
breakthrough
technology
effective
unnecessary
compounds
order
increase
neuroprotection
CNS
well
prevent
or
delay
various
diseases.
Alzheimer s & Dementia,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 29, 2025
Abstract
INTRODUCTION
Changes
in
sleep
physiology
can
predate
cognitive
symptoms
by
decades
persons
with
Alzheimer's
disease
(AD),
but
it
remains
unclear
which
characteristics
predict
and
neurodegenerative
changes
after
AD
onset.
METHODS
Using
data
from
a
prospective
cohort
of
mild
to
moderate
(
n
=
60),
we
analyzed
non‐rapid
eye
movement
spindles
slow
oscillations
(SOs)
at
baseline
their
associations
amyloid
beta
(Aβ)
tau
cognition
3‐year
follow‐up.
RESULTS
Higher
spindle
SO
activity
predicted
significant
Aβ
baseline,
lower
Disease
Assessment
Scale
Cognitive
Subscale
(better
performance)
score,
higher
Mini‐Mental
State
Examination
score
36
months.
Spindles
SOs
mediated
the
effect
phosphorylated
181
(pTau181)/Aβ42
on
cognition,
while
pTau181/aβ42
moderated
cognition.
DISCUSSION
Our
findings
demonstrate
that
during
constitute
predictive
non‐invasive
biomarkers
neurodegeneration
patients.
Highlights
Sleep
long‐term
performance
AD.
be
predictive,
for
may
one
most
important
modifiable
risk
factors
progression.
microarchitecture
is
novel
therapeutic
target
preserving
brain
heath.
provide
targets
Frontiers in Neuroscience,
Год журнала:
2020,
Номер
14
Опубликована: Сен. 23, 2020
Even
prior
to
the
onset
of
prodromal
stages
Alzheimer's
disease
(AD),
a
constellation
sleep
disturbances
are
apparent.
A
series
epidemiological
studies
indicate
that
multiple
forms
these
associated
with
increased
risk
for
developing
mild
cognitive
impairment
(MCI)
and
AD,
even
triggering
at
an
earlier
age.
Through
combination
causal
manipulation
in
humans
rodents,
as
well
targeted
examination
disturbance
respect
AD
biomarkers,
mechanisms
linking
beginning
emerge.
In
this
review,
we
explore
recent
evidence
local
deficits
brain
oscillatory
function
during
pathological
burden
circuit-level
dysfunction
degeneration.
short,
three
expression
oscillations
have
been
identified
relation
pathophysiology:
1)
frequency-specific
frontal
slow
wave
non-rapid
eye
movement
(NREM)
sleep,
2)
parietal
spindle
expression,
3)
quality
electroencephalographic
(EEG)
desynchrony
characteristic
REM
sleep.
These
noteworthy
since
they
differ
from
seen
normal
aging,
indicating
potential
presence
abnormal
aging
process.
How
each
β-amyloid
(Aβ)
tau
pathology,
neurodegeneration
circuits
sensitive
pathophysiology,
examined
present
focus
on
role
within
fronto-hippocampal
subcortical
sleep-wake
circuits.
It
is
hypothesized
arise
distinct
network-specific
dysfunctions
driven
by
regionally-specific
accumulation
pathologies,
their
neurodegeneration.
Overall,
evolution
offer
unique
windows
into
circuit-specific
progression
pathophysiological
processes
onset,
impact
function.
This
includes
erosion
sleep-dependent
memory
mechanisms,
which
may
contribute
decline
AD.
review
closes
discussion
remaining
critical
knowledge
gaps
implications
work
future
mechanistic
implementing
sleep-based
treatment
interventions.
Alzheimer s Research & Therapy,
Год журнала:
2020,
Номер
12(1)
Опубликована: Май 13, 2020
Abstract
Background
The
panel
of
fluid-
and
imaging-based
biomarkers
available
for
neurodegenerative
disease
research
is
growing
has
the
potential
to
close
important
gaps
in
clinic.
With
this
growth
increasing
use,
appropriate
implementation
interpretation
are
paramount.
Various
feature
nuanced
differences
strengths,
limitations,
biases
that
must
be
considered
when
investigating
etiology
clinical
utility.
For
example,
neuropathological
investigations
Alzheimer’s
pathogenesis
can
fall
disagreement
with
conclusions
reached
by
biomarker-based
investigations.
Considering
varied
different
methodologies
approaches
may
help
harmonize
disciplines
within
field.
Purpose
review
Along
separate
articles
covering
fluid
imaging
issue
Research
Therapy
,
we
present
result
a
discussion
from
2019
Biomarkers
Neurodegenerative
Diseases
course
at
University
College
London.
Here,
discuss
themes
biomarker
use
research,
commenting
on
interpretation,
considerations
across
diseases.
We
also
draw
attention
areas
where
combined
other
understand
issues
pathophysiology
underlying
dementia.
Lastly,
highlight
novel
modalities
have
been
proposed
landscape
care.
