bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 25, 2023
Abstract
Growing
up
in
a
high
poverty
neighborhood
is
associated
with
elevated
risk
for
academic
challenges
and
health
problems.
Here,
we
take
data-driven
approach
to
exploring
how
measures
of
children’s
environments
relate
the
development
their
brain
structure
function
community
sample
children
between
ages
4
10
years.
We
constructed
exposomes
including
family
socioeconomic
status,
exposure
adversity,
geocoded
crime,
environmental
toxins.
connected
exposome
two
structural
(cortical
thickness
surface
area,
n
=
170)
functional
(participation
coefficient
clustering
coefficient,
130).
found
dense
connections
within
layers
sparse
layers.
Lower
income
was
thinner
visual
cortex,
consistent
theory
that
accelerated
detectable
early-developing
regions.
Greater
incidence
blood
lead
levels
greater
segregation
default
mode
network,
evidence
toxins
are
deposited
into
along
midline.
Our
study
demonstrates
utility
multilayer
network
analysis
bridge
neural
explanatory
better
understand
complexity
child
development.
Human Brain Mapping,
Год журнала:
2024,
Номер
45(6)
Опубликована: Апрель 15, 2024
The
unprecedented
increase
in
life
expectancy
presents
a
unique
opportunity
and
the
necessity
to
explore
both
healthy
pathological
aspects
of
ageing.
Electroencephalography
(EEG)
has
been
widely
used
identify
neuromarkers
cognitive
ageing
due
its
affordability
richness
information.
However,
despite
growing
volume
data
methodological
advancements,
abundance
contradictory
non-reproducible
findings
hindered
clinical
translation.
To
address
these
challenges,
our
study
introduces
comprehensive
workflow
expanding
on
previous
EEG
studies
investigates
various
static
dynamic
power
connectivity
estimates
as
potential
large
dataset.
We
also
assess
robustness
by
testing
their
susceptibility
band
specification.
Finally,
we
characterise
using
functionally
annotated
brain
networks
improve
interpretability
multi-modal
integration.
Our
analysis
demonstrates
effect
choices
that
rather
than
are
not
only
more
sensitive
but
robust.
Consequently,
they
emerge
strong
candidates
for
neuromarkers.
Moreover,
were
able
replicate
most
established
ageing,
such
alpha
oscillation
slowing,
increased
beta
power,
reduced
reactivity
across
multiple
bands,
decreased
delta
connectivity.
Additionally,
when
considering
individual
variations
band,
clarified
is
characteristic
memory
performance
highlighting
neuromarker
approach
source
reconstruction
allowed
us
provide
insights
into
domain-specific
electrophysiological
mechanisms
underlying
HIGHLIGHTS:
an
open
reproducible
pipeline
with
investigate
Neuromarkers
related
neural
dynamics
Individualised
characterises
Functional
annotation
allows
cross-modal
interpretation
findings.
Communications Biology,
Год журнала:
2024,
Номер
7(1)
Опубликована: Авг. 14, 2024
The
ability
to
organize
and
memorize
the
unfolding
of
events
over
time
is
a
fundamental
feature
cognition,
which
develops
concurrently
with
maturation
brain.
Nonetheless,
how
temporal
processing
evolves
across
lifetime
as
well
links
underlying
neural
substrates
remains
unclear.
Here,
we
intend
retrace
main
developmental
stages
brain
structure,
function,
cognition
linked
emergence
timing
abilities.
This
neurodevelopmental
perspective
aims
untangle
puzzling
trajectory
aspects
lifetime,
paving
way
novel
neuropsychological
assessments
cognitive
rehabilitation
strategies.
A
new
aiming
processing's
throughout
lifetime.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 25, 2023
Abstract
Growing
up
in
a
high
poverty
neighborhood
is
associated
with
elevated
risk
for
academic
challenges
and
health
problems.
Here,
we
take
data-driven
approach
to
exploring
how
measures
of
children’s
environments
relate
the
development
their
brain
structure
function
community
sample
children
between
ages
4
10
years.
We
constructed
exposomes
including
family
socioeconomic
status,
exposure
adversity,
geocoded
crime,
environmental
toxins.
connected
exposome
two
structural
(cortical
thickness
surface
area,
n
=
170)
functional
(participation
coefficient
clustering
coefficient,
130).
found
dense
connections
within
layers
sparse
layers.
Lower
income
was
thinner
visual
cortex,
consistent
theory
that
accelerated
detectable
early-developing
regions.
Greater
incidence
blood
lead
levels
greater
segregation
default
mode
network,
evidence
toxins
are
deposited
into
along
midline.
Our
study
demonstrates
utility
multilayer
network
analysis
bridge
neural
explanatory
better
understand
complexity
child
development.
