bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Июль 29, 2023
Abstract
When
holding
visual
information
temporarily
in
working
memory
(WM),
the
neural
representation
of
memorandum
is
distributed
across
various
cortical
regions,
including
and
frontal
cortices.
However,
role
stimulus
cortices
during
WM
has
been
controversial.
Here
we
tested
hypothesis
that
persists
cortex
to
facilitate
flexible
control
demands
WM.
During
functional
MRI,
participants
flexibly
switched
between
simple
maintenance
or
more
complex
rule-based
categorization
maintained
on
a
trial-by-trial
basis.
Our
results
demonstrated
enhanced
tracked
for
active
precise
maintenance.
This
differential
traded
off
with
newly-generated
category
varying
demands.
Simulation
using
multi-module
recurrent
networks
replicated
human
patterns
when
was
preserved
network
readout.
Altogether,
these
findings
help
reconcile
long-standing
debate
research,
provide
empirical
computational
evidence
serves
as
potential
coding
scheme
accommodate
ever-changing
environment.
Abstract
Previous
working
memory
research
has
demonstrated
robust
stimulus
representations
during
maintenance
in
both
voltage
and
alpha-band
activity
electroencephalography.
However,
the
exact
functions
of
these
2
neural
signatures
have
remained
controversial.
Here
we
systematically
investigated
their
respective
contributions
to
manipulation.
Human
participants
either
maintained
a
previously
seen
spatial
location,
or
manipulated
location
following
mental
rotation
cue
over
delay.
Using
multivariate
decoding,
observed
low-frequency
oscillatory
with
distinct
spatiotemporal
dynamics:
were
most
evident
posterior
channels
activity,
but
prominent
more
anterior,
central
signals.
Moreover,
temporal
emergence
representation
preceded
that
suggesting
might
carry
stimulus-specific
source
signals
originated
internally
from
anterior
cortex,
whereas
reflect
feedback
cortex
received
higher-order
cortex.
Lastly,
while
coded
low-dimensional
subspace,
was
higher-dimensional
underwent
representational
transformation
exclusively
predicted
behavior.
Together,
results
highlight
crucial
role
memory,
support
functional
distinctions
between
activity.
Cell Reports,
Год журнала:
2023,
Номер
42(10), С. 113242 - 113242
Опубликована: Окт. 1, 2023
Visual
imagery
allows
for
the
construction
of
rich
internal
experience
in
our
mental
world.
However,
it
has
remained
poorly
understood
how
derives
volitionally
as
opposed
to
being
cue
driven.
Here,
using
electroencephalography
and
functional
magnetic
resonance
imaging,
we
systematically
investigate
spatiotemporal
dynamics
self-generated
by
having
participants
imagining
one
orientations
from
a
learned
pool.
We
contrast
with
cue-induced
imagery,
where
imagined
line
based
on
associative
cues
acquired
previously.
Our
results
reveal
overlapping
neural
signatures
imagery.
Yet,
these
display
substantially
differential
sensitivities
two
types
imagery:
is
supported
an
enhanced
involvement
anterior
cortex
representing
contents.
By
contrast,
representations
posterior
visual
cortex.
These
jointly
support
reverse
cortical
hierarchy
generating
maintaining
contents
versus
externally
cued
When
holding
visual
information
temporarily
in
working
memory
(WM),
the
neural
representation
of
memorandum
is
distributed
across
various
cortical
regions,
including
and
frontal
cortices.
However,
role
stimulus
cortices
during
WM
has
been
controversial.
Here
we
tested
hypothesis
that
persists
cortex
to
facilitate
flexible
control
demands
WM.
During
functional
MRI,
participants
flexibly
switched
between
simple
maintenance
or
more
complex
rule-based
categorization
maintained
on
a
trial-by-trial
basis.
Our
results
demonstrated
enhanced
tracked
for
active
precise
maintenance.
This
differential
traded
off
with
newly-generated
category
varying
demands.
Simulation
using
multi-module
recurrent
networks
replicated
human
patterns
when
was
preserved
network
readout.
Altogether,
these
findings
help
reconcile
long-standing
debate
research,
provide
empirical
computational
evidence
serves
as
potential
coding
scheme
accommodate
ever-changing
environment.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Abstract
People
typically
remember
seeing
a
greater
expanse
of
scene
than
was
visible
in
studied
close-up
(boundary
extension,
BE).
Multivoxel
pattern
analysis
used
to
test
the
neural
correlates
BE.
Classifiers
were
trained
using
whole-brain
searchlight
method
discriminate
between
and
wider-angle
versions
16
scenes
during
repeated
perceptual
exposures.
Earlier,
each
subject
either
close
or
wide
version
then
visually
imagined
it
from
memory.
If
brain
region
reflects
BE,
unlike
classification
perception,
visual
images
views
should
sometimes
be
misclassified
as
(capturing
false
memory
beyond
view),
whereas
correctly
classified.
BE-consistent
patterns
imagery
found
high-level
regions,
including
posterior
superior
parietal
cortex.
This
did
not
reflect
brain-wide
bias
toward
better
views:
reversed
(better
views)
early
cortex,
presenting
novel
distinction
late
representations
imagery.
We
propose
that
this
active
maintenance
boundary-extended
holds
promise
general
purpose
tool
for
decoding
brain.
When
holding
visual
information
temporarily
in
working
memory
(WM),
the
neural
representation
of
memorandum
is
distributed
across
various
cortical
regions,
including
and
frontal
cortices.
However,
role
stimulus
cortices
during
WM
has
been
controversial.
Here
we
tested
hypothesis
that
persists
cortex
to
facilitate
flexible
control
demands
WM.
During
functional
MRI,
participants
flexibly
switched
between
simple
maintenance
or
more
complex
rule-based
categorization
maintained
on
a
trial-by-trial
basis.
Our
results
demonstrated
enhanced
tracked
for
active
precise
maintenance.
This
differential
traded
off
with
newly-generated
category
varying
demands.
Simulation
using
multi-module
recurrent
networks
replicated
human
patterns
when
was
preserved
network
readout.
Altogether,
these
findings
help
reconcile
long-standing
debate
research,
provide
empirical
computational
evidence
serves
as
potential
coding
scheme
accommodate
ever-changing
environment.
When
holding
visual
information
temporarily
in
working
memory
(WM),
the
neural
representation
of
memorandum
is
distributed
across
various
cortical
regions,
including
and
frontal
cortices.
However,
role
stimulus
cortices
during
WM
has
been
controversial.
Here,
we
tested
hypothesis
that
persists
cortex
to
facilitate
flexible
control
demands
WM.
During
functional
MRI,
participants
flexibly
switched
between
simple
maintenance
or
more
complex
rule-based
categorization
maintained
on
a
trial-by-trial
basis.
Our
results
demonstrated
enhanced
tracked
for
active
precise
maintenance.
This
differential
traded
off
with
newly-generated
category
varying
demands.
Simulation
using
multi-module
recurrent
networks
replicated
human
patterns
when
was
preserved
network
readout.
Altogether,
these
findings
help
reconcile
long-standing
debate
research,
provide
empirical
computational
evidence
serves
as
potential
coding
scheme
accommodate
ever-changing
environment.
When
holding
visual
information
temporarily
in
working
memory
(WM),
the
neural
representation
of
memorandum
is
distributed
across
various
cortical
regions,
including
and
frontal
cortices.
However,
role
stimulus
cortices
during
WM
has
been
controversial.
Here
we
tested
hypothesis
that
persists
cortex
to
facilitate
flexible
control
demands
WM.
During
functional
MRI,
participants
flexibly
switched
between
simple
maintenance
or
more
complex
rule-based
categorization
maintained
on
a
trial-by-trial
basis.
Our
results
demonstrated
enhanced
tracked
for
active
precise
maintenance.
This
differential
traded
off
with
newly-generated
category
varying
demands.
Simulation
using
multi-module
recurrent
networks
replicated
human
patterns
when
was
preserved
network
readout.
Altogether,
these
findings
help
reconcile
long-standing
debate
research,
provide
empirical
computational
evidence
serves
as
potential
coding
scheme
accommodate
ever-changing
environment.
When
holding
visual
information
temporarily
in
working
memory
(WM),
the
neural
representation
of
memorandum
is
distributed
across
various
cortical
regions,
including
and
frontal
cortices.
However,
role
stimulus
cortices
during
WM
has
been
controversial.
Here
we
tested
hypothesis
that
persists
cortex
to
facilitate
flexible
control
demands
WM.
During
functional
MRI,
participants
flexibly
switched
between
simple
maintenance
or
more
complex
rule-based
categorization
maintained
on
a
trial-by-trial
basis.
Our
results
demonstrated
enhanced
tracked
for
active
precise
maintenance.
This
differential
traded
off
with
newly-generated
category
varying
demands.
Simulation
using
multi-module
recurrent
networks
replicated
human
patterns
when
was
preserved
network
readout.
Altogether,
these
findings
help
reconcile
long-standing
debate
research,
provide
empirical
computational
evidence
serves
as
potential
coding
scheme
accommodate
ever-changing
environment.
