Integrating and fragmenting memories under stress and alcohol

Neurobiology of Stress, Год журнала: 2024, Номер 30, С. 100615 - 100615

Опубликована: Фев. 8, 2024

Stress can powerfully influence the way we form memories, particularly extent to which they are integrated or situated within an underlying spatiotemporal and broader knowledge architecture. These different representations in turn have significant consequences for use these memories guide later behavior. Puzzlingly, although stress has historically been argued promote fragmentation, leading disjoint memory representations, more recent work suggests that also facilitate binding integration. Understanding circumstances under fosters integration will be key resolving this discrepancy unpacking mechanisms by shape Here, examine at multiple levels: linking together content of individual experience, threading associations between related but distinct events, experience into a pre-existing schema sense causal structure. We discuss neural cognitive each as well findings regarding how stress, aversive learning, negative affect modulate each. In analysis, uncover indeed level show may apply understanding effects alcohol, highlighting extant clinical preclinical opportunities further investigation. Finally, consider implications fragmentation memory-guided behavior, importance type representation is potentiated order design appropriate interventions.

Язык: Английский

---

Understanding the Interplay Between Stress, Anxiety, and Depression and Their Impact on Health in Traffic Police Officers

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Background Traffic police officers are frequently exposed to stress, anxiety, and depression, which adversely impact their health. This study hypothesized that these factors influence the hormonal, muscular, digestive, cognitive systems of traffic officers. Methods The sample comprised 146 (42 women 104 men) aged 30 38. Gender differences in symptoms were examined, model fit was assessed using indicators such as chi-square, comparative index, root mean square error approximation (RMSEA), standardized means residual (SRMR). Results observed, with reporting more significant issues related symptoms. models demonstrated a good fit, particularly examining digestive Conclusions findings indicate substantial depression on officers' Psychological support monitoring recommended at stations. results align previous research underscore need for targeted interventions address health challenges faced by specialized groups daily stressors.

Язык: Английский

---

Positive affect amplifies integration within episodic memories in the laboratory and the real world

Learning & Memory, Год журнала: 2025, Номер 32(1), С. a053971 - a053971

Опубликована: Янв. 1, 2025

Emotional events hold a privileged place in our memories, differing accuracy and structure from memories for neutral experiences. Although much work has focused on the pronounced differences memory negative experiences, there is growing evidence that positive may lead to more holistic, or integrated, memories. However, it unclear whether these affect-driven changes structure, which have been found highly controlled laboratory environments, extend real-world episodic We ran experiments assessed experiences created (Experiment 1) and, using smartphones, everyday 2). complement design innovations with novel analysis approach model integration both settings. Consistent past findings, emotional were subjectively remembered strongly. These studies also revealed features of indeed integrated within memory, real world. effects specific participants’ responses during encoding rather than general states at time retrieval, reflected increase between multiple features. Together, results demonstrate robust events, introduce measure integration, highlight importance assessing impact emotion beyond laboratory.

Язык: Английский

---

Distinct cortisol effects on item and associative memory across memory phases

Psychoneuroendocrinology, Год журнала: 2025, Номер 176, С. 107422 - 107422

Опубликована: Март 14, 2025

Язык: Английский

---

Amomum tsao-ko crevost et lemaire ameliorates depression-like behaviors and hippocampal inflammation by inhibiting microglia activation and HMGB1/TLR4/NF-κB pathway in diabetic mice with depression

Metabolic Brain Disease, Год журнала: 2025, Номер 40(4)

Опубликована: Март 28, 2025

Язык: Английский

---

Lycium barbarum polysaccharide ameliorates corticosterone-induced cognition decline with modulation of CRHR1

Brain Research Bulletin, Год журнала: 2025, Номер unknown, С. 111346 - 111346

Опубликована: Апрель 1, 2025

Lycium barbarum polysaccharide (LBP) has anti-inflammatory, anti-oxidation and anti-aging properties, but the mechanism of LBP on stress-induced cognitive dysfunction caused by elevated GC level is still unclear. Therefore, present study aimed to investigate corticosterone-injected（CORT-injected） impairment. The rat model was induced corticosterone in vivo. Water maze test HE staining were used observe effect function brain morphology CORT-injected rats. RT-qPCR, Western blot, immunofluorescence detect expression proteins. SH-SY5Y cells treated with CORT D-gal vitro, respectively. cell proliferation observed, western blotting detected protein expressions. In this study, treatment ameliorated CORT-induced learning protected hypothalamic hippocampal neurons from injury addition, reduced plasma concentrations results also indicated that enhanced synapsis-related proteins PSD95 SYN up-regulating CRHR1 RGS2 hippocampus hypothalamus group. Meanwhile, we confirmed - D-Gal-induced further verified changes CRHR1, RGS2, synapse-related This demonstrates cognition decline regulating CRHR1. may represent a potential drug for prevention patients increased GCs.

Язык: Английский

---

Acute Stress Effects on Statistical Learning and Episodic Memory

Journal of Cognitive Neuroscience, Год журнала: 2024, Номер 36(8), С. 1741 - 1759

Опубликована: Янв. 1, 2024

Stress is widely considered to negatively impact hippocampal function, thus impairing episodic memory. However, the hippocampus not merely seat of Rather, it also (via distinct circuitry) supports statistical learning. On basis rodent work suggesting that stress may impair pathway involved in memory while sparing or enhancing learning, we developed a behavioral experiment investigate effects acute on both and learning humans. Participants were randomly assigned one three conditions: (socially evaluated cold pressor) immediately before ∼15 min no stress. In task, participants viewed series trial-unique scenes (allowing for encoding each image) which certain scene categories reliably followed another associations between paired categories). Memory was assessed 24 hr later isolate encoding/learning rather than retrieval. We found modest support our hypothesis can amplify learning: Only stressed advance exhibited reliable evidence across multiple measures. Furthermore, stress-induced cortisol levels predicted retention later. contrast, did differ by condition, although find preliminary promoted statistically predictable information attenuated competition encoding. Together, these findings provide initial insights into how differentially modulate processes within hippocampus.

Язык: Английский

---

Acute stress effects on statistical learning and episodic memory

Опубликована: Янв. 13, 2024

Stress is widely considered to negatively impact hippocampal function, thus impairing episodic memory. However, the hippocampus not merely seat of Rather, it also (via distinct circuitry) supports statistical learning. Based on rodent work suggesting that stress may impair pathway involved in memory while sparing or enhancing learning, we developed a behavioral experiment investigate effects acute both and learning humans. Participants were randomly assigned one three conditions: (socially evaluated cold pressor) immediately before ~15 minutes no stress. In task, participants viewed series trial-unique scenes (allowing for encoding each image) which certain scene categories reliably followed another associations between paired categories). Memory was assessed 24h later isolate encoding/learning rather than retrieval. We found modest support our hypothesis can amplify learning: only stressed advance exhibited reliable evidence across multiple measures. Further, stress-induced cortisol levels predicted retention later. contrast, did differ by condition, though find promoted statistically predictable information attenuated competition encoding. Together, these findings provide initial insights into how differentially modulate processes within hippocampus.

Язык: Английский

---

Drawbacks to strengthening neural salience encoding: a link between cortisol and risky drinking

Journal of Neuroscience, Год журнала: 2024, Номер 44(40), С. e1027242024 - e1027242024

Опубликована: Авг. 15, 2024

Emotionally salient experiences are encoded and remembered more strongly, an effect that can be amplified by hormones like cortisol. Such memories in turn profoundly influence later behavior. However, little is known about the link between salience encoding subsequent This pathway may particularly important for risky alcohol drinking, which has been linked to sensitized responses, memory, To test this possibility, we integrated pharmacology using a double-blind cross-over design with fMRI, cognitive, motivation assays across range of healthy male female social drinkers. As anticipated, cortisol enhanced memory alcohol-related events; critically, bias was associated motivation. Increased pronounced susceptible drinkers, whom brain responses alcohol. These predicted both biases Together, these findings reveal maladaptive consequences encoding.

Язык: Английский

---

Stress warps fear memories in multiple ways

The Transmitter, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

---