Sensation is dispensable for the maturation of the vestibulo-ocular reflex

Science, Год журнала: 2025, Номер 387(6729), С. 85 - 90

Опубликована: Янв. 2, 2025

Vertebrates stabilize gaze using a neural circuit that transforms sensed instability into compensatory counterrotation of the eyes. Sensory feedback tunes this vestibulo-ocular reflex throughout life. We studied functional development components in larval zebrafish, with and without sensation. Blind fish normally, responses to body tilts mature before behavior. In contrast, synapses between motor neurons eye muscles time course similar behavioral maturation. Larvae vestibular sensory experience, but neuromuscular junctions, had strong reflex. Development junction, not therefore determines rate maturation an ancient

Язык: Английский

---

Aging in a weighted ensemble of excitable and self-oscillatory neurons: The role of pairwise and higher-order interactions

Chaos An Interdisciplinary Journal of Nonlinear Science, Год журнала: 2025, Номер 35(1)

Опубликована: Янв. 1, 2025

We investigate the aging transition in networks of excitable and self-oscillatory units as fraction inherently increases. Two network topologies are considered: a scale-free with weighted pairwise interactions two-dimensional simplicial complex triadic interactions. Without interactions, from collective oscillations to oscillation death (inhomogeneous stationary states) can occur either suddenly or through an intermediate state partial oscillation. However, when present, becomes less resilient, occurs without at any coupling strength. Furthermore, we observe presence inhomogeneous steady states within complete regime, regardless interaction models.

Язык: Английский

---

Discovering motifs to fingerprint multi-layer networks: a case study on the connectome of C. Elegans

The European Physical Journal B, Год журнала: 2025, Номер 98(1)

Опубликована: Янв. 1, 2025

Язык: Английский

---

Three systems of circuit formation: assembly, updating and tuning

Nature reviews. Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

Язык: Английский

---

Rethinking Depression—Beyond Neurotransmitters: An Integrated Psychoneuroendocrineimmunology Framework for Depression’s Pathophysiology and Tailored Treatment

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2759 - 2759

Опубликована: Март 19, 2025

It is known that the effectiveness of drug treatment for depression, ammine deficit based, largely unsatisfactory. In this review, we examine proposal a precision therapy has emerged and received strong push by identification role inflammation in depression. However, psychiatry risks being caught reductionist trap searching molecular switch resets whole system switches off disease. This an illusion since human complex depression systemic variable disorder. study, show inadequacy paradigm, and, at same time, illustrate superiority paradigm centered on psychoneuroendocrineimmunology (PNEI). According to PNEI disease being, caused different sources working together: psychological, biological, behavioral. means knowing biological psychological history subject, identifying relational crisis factors, building personalized treatments targeting those factors with tools medicine psychology, which are not reducible combination drugs psychotherapy. Our presents shift both theoretical practical, enables clinicians assess patients experiencing unified way treat them integrated manner.

Язык: Английский

---

Causal Contributions and Interhemispheric Interactions of the Left and Right Supramarginal Gyri in Vocal Feedback Control: Insights From Dual‐Site Transcranial Magnetic Stimulation

Psychophysiology, Год журнала: 2025, Номер 62(4)

Опубликована: Апрель 1, 2025

ABSTRACT The bilateral supramarginal gyri (SMGs) have been implicated in sensorimotor control of speech production, yet their precise roles and interhemispheric interactions are poorly understood. This event‐related potential study employed dual‐site continuous theta burst stimulation (c‐TBS) over the SMGs simultaneously to investigate functional dynamics vocal motor control. Following unilateral c‐TBS SMG as well sham stimulation, participants vocalized vowel sounds while exposed unexpected pitch perturbations auditory feedback. Unilateral real paired with contralateral led reduced compensation magnitudes latencies decreased P2 responses compared no differences between left right stimulation. Source localization revealed that following localized left‐lateralized dorsolateral prefrontal cortex, supplementary area, SMG, middle temporal gyrus, temporo‐parietal junction, whereas such decreases involved primary premotor gyrus. These findings suggest both causally feedback through distinct but interconnected networks. Surprisingly, did not alter or cortical activity, suggesting an balancing mechanism for fine‐tuning production. Our results offer novel insights into bihemispheric coordination auditory‐vocal integration, highlighting treatment disorders by modulating interactions.

Язык: Английский

---

What Is Grounded Simulation?

Journal for the Theory of Social Behaviour, Год журнала: 2025, Номер 55(2)

Опубликована: Апрель 10, 2025

ABSTRACT The capacity to mentally simulate objects and events is an important yet underexplored component in sociological theorising. Recent research drawing on simulation from the cognitive sciences suggests opportunities for new insights via a richer interdisciplinary engagement. To this end, we provide thorough review of literature grounded theory, building nascent work sociology engaging with discuss its potential analysis. We highlight utility as cognitively plausible framework addressing issues analysis culture action thinking, including questions salience, novelty, implicit cognition, deliberation relation between Type 1 2 processing. conclude some considerations future research.

Язык: Английский

---

Mesoscale brain-wide fluctuation analysis: revealing ketamine’s rapid antidepressant across multiple brain regions

Translational Psychiatry, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 19, 2025

Depression has been linked to cortico-limbic brain regions, and ketamine is known for its rapid antidepressant effects. However, how these regions encode depression collaboratively regulates exert prompt effects through mesoscale brain-wide fluctuations remain elusive. In this study, we used a multidisciplinary approach, including multi-region in vivo recordings mice, chronic social defeat stress (CSDS), machine learning, construct Mesoscale Brain-Wide Fluctuation Analysis platform (MBFA-platform). This analyzes the of multiple from perspective local field potential oscillations network dynamics. The decoder results demonstrate that our MBFA can accurately classify Control/CSDS ketamine/saline-treated groups based on neural oscillation activities among eight regions. We found multiple-region LFPs patterns are disrupted CSDS-induced avoidance, with basolateral amygdala playing key role. Ketamine primarily exerts compensatory dynamics, contributing effect. These findings highlight as an interdisciplinary tool revealing underlying complex emotional pathologies, providing insights into etiology psychiatry. Furthermore, platform's evaluation capabilities present novel approach psychiatric therapeutic interventions.

Язык: Английский

---

A complex network-based approach to detect and investigate connectome motifs in the larval Drosophila

Computers in Biology and Medicine, Год журнала: 2025, Номер 192, С. 110135 - 110135

Опубликована: Апрель 25, 2025

Analyzing the connectome of an organism allows us to understand how different areas its brain communicate with each other and structure is related function. Thanks new technological advances, increasingly complex organisms has been reconstructed in recent years. Drosophila melanogaster currently most whose complete known, both structurally functionally. In this paper, we aim contribute study structural by proposing ad hoc approach for discovery network motifs that may be present it. Unlike previous approaches, which focused on parts or entire very simple organisms, our operates at whole-brain scale known. Furthermore, while works have extending existing motif extraction approaches case, proposes a concept specifically designed organism. This find abstracting them into few types take account regions neurons involved belong.

Язык: Английский

---

Most dynorphin neurons in the zona incerta-perifornical area are active in waking relative to non-rapid-eye movement and rapid-eye movement sleep

SLEEP, Год журнала: 2024, Номер 47(5)

Опубликована: Март 6, 2024

Abstract Dynorphin is an endogenous opiate localized in many brain regions and spinal cord, but the activity of dynorphin neurons during sleep unknown. inhibitory neuropeptide that coreleased with orexin, excitatory neuropeptide. We used microendoscopy to test hypothesis that, like are wake-active. Dynorphin-cre mice (n = 3) were administered rAAV8-Ef1a-Con/Foff 2.0-GCaMP6M into zona incerta-perifornical area, implanted a GRIN lens (gradient reflective index), electrodes skull recorded sleep. One month later, miniscope imaged calcium fluorescence multiple bouts wake, non-rapid-eye movement (NREM), rapid-eye (REM) Unbiased data analysis identified changes 64 neurons. Most (72%) had highest active quiet waking compared NREM or REM sleep; subset (20%) REM-max. Our results consistent emerging evidence orexin can be classified as wake-max Since two neuropeptides coexpressed coreleased, we suggest dynorphin-cre-driven sensors could increase understanding role this pain

Язык: Английский

---