The Influence of Autoregressive Relation Strength and Search Strategy on Directionality Recovery in GIMME DOI
Alexander Weigard, Stephanie Lane, Kathleen M. Gates

и другие.

Опубликована: Авг. 28, 2020

Unified structural equation modeling (uSEM) implemented in the Group Iterative Multiple Model Estimation (GIMME) framework has recently been widely used for characterizing within-person network dynamics of behavioral and functional neuroimaging variables. Previous studies have established that GIMME accurately recovers presence relations between However, recovery relation directionality is less consistent, which concerning given importance estimates many research questions. There evidence strong autoregressive may aid indirect a novel version allowing multiple solutions could improve when such are weak, but it remains unclear how these strategies perform under range study conditions. Using comprehensive simulations varied strength among other factors, this evaluated two search strategies: 1) estimating by default null model (GIMME-AR), 2) generating solution paths (GIMME-MS). Both recovered best – were roughly equivalent performance (e.g., β = .60). When they weak (β <= .10), GIMME-MS displayed an advantage, although overall was modest. Analyses empirical data characteristically (resting state fMRI) versus (daily diary) mirrored simulation results confirmed can disagree on weak. Findings important implications psychological applications uSEM/GIMME suggest specific scenarios researchers might or not be confident results.

Язык: Английский

Oligodendrocyte calcium signaling promotes actin-dependent myelin sheath extension DOI Creative Commons
Manasi Iyer, Husniye Kantarci, Madeline H. Cooper

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Янв. 4, 2024

Abstract Myelin is essential for rapid nerve signaling and increasingly found to play important roles in learning diverse diseases of the CNS. Morphological parameters myelin such as sheath length are thought precisely tune conduction velocity, but mechanisms controlling morphology poorly understood. Local calcium has been observed nascent sheaths can be modulated by neuronal activity. However, role formation remains incompletely Here, we use genetic tools attenuate oligodendrocyte during myelination developing mouse Surprisingly, attenuation does not grossly affect number myelinated axons or thickness. Instead, causes defects resulting shorter, dysmorphic sheaths. Mechanistically, reduces actin filaments oligodendrocytes, an intact cytoskeleton necessary sufficient achieve accurate morphology. Together, our work reveals a cellular mechanism required CNS may provide mechanistic insight into how oligodendrocytes respond activity sculpt refine

Язык: Английский

Процитировано

19
The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing DOI Creative Commons
Katrin Amunts, Markus Axer, Swati Banerjee

и другие.

Imaging Neuroscience, Год журнала: 2024, Номер 2, С. 1 - 35

Опубликована: Апрель 1, 2024

Abstract In recent years, brain research has indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration modelling at multiple scales—from molecules to the whole brain. Major are emerging intersection of neuroscience with technology computing. This science combines high-quality research, across scales, culture multidisciplinary large-scale collaboration, translation into applications. As pioneered in Europe’s Human Brain Project (HBP), systematic approach will be essential for meeting coming decade’s pressing medical technological challenges. The aims this paper to: develop concept decade digital discuss community large, identify points convergence, derive therefrom scientific common goals; provide framework current future development EBRAINS, infrastructure resulting from HBP’s work; inform engage stakeholders, funding organisations institutions regarding research; address transformational potential comprehensive models artificial intelligence, including machine learning deep learning; outline collaborative that integrates reflection, dialogues, societal engagement on ethical opportunities challenges as part research.

Язык: Английский

Процитировано

16
Tapis: An API Platform for Reproducible, Distributed Computational Research DOI
Joe Stubbs, Richard Cardone,

Mike Packard

и другие.

Advances in intelligent systems and computing, Год журнала: 2021, Номер unknown, С. 878 - 900

Опубликована: Янв. 1, 2021

Язык: Английский

Процитировано

34
Analytical prediction of specific spatiotemporal patterns in nonlinear oscillator networks with distance-dependent time delays DOI Creative Commons
Roberto C. Budzinski, Tung T. Nguyen,

Gabriel Benigno

и другие.

Physical Review Research, Год журнала: 2023, Номер 5(1)

Опубликована: Март 2, 2023

We introduce an analytical approach that allows predictions and mechanistic insights into the dynamics of nonlinear oscillator networks with heterogeneous time delays. demonstrate delays shape spectrum a matrix associated to system, leading emergence waves preferred direction. then create for specific spatiotemporal patterns observed in individual simulations time-delayed Kuramoto networks. This generalizes systems at finite scales, which permits study broad range applications.

Язык: Английский

Процитировано

13
Violation of the ultrastructural size principle in the dorsolateral prefrontal cortex underlies working memory impairment in the aged common marmoset (Callithrix jacchus) DOI Creative Commons
Courtney Glavis‐Bloom, Casey R. Vanderlip, Sammy Weiser Novak

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2023, Номер 15

Опубликована: Апрель 12, 2023

Morphology and function of the dorsolateral prefrontal cortex (dlPFC), corresponding working memory performance, are affected early in aging process, but nearly half aged individuals spared deficits. Translationally relevant model systems critical for determining neurobiological drivers this variability. The common marmoset (Callithrix jacchus) is advantageous as a these investigations because, non-human primate, marmosets have clearly defined dlPFC that enables measurement prefrontal-dependent cognitive functions, their short (∼10 year) lifespan facilitates longitudinal studies aging. Previously, we characterized capacity cohort collectively covered lifespan, found age-related impairment. We also remarkable degree heterogeneity similar to humans. Here, tested hypothesis changes synaptic ultrastructure affect efficacy stratify age with impairment from those without utilized electron microscopy visualize synapses measured sizes boutons, presynaptic mitochondria, synapses. coordinated scaling mitochondria associated boutons essential intact performance marmosets. Further, lack scaling, due failure scale selectively underlies posit decoupling results mismatched energy supply demand, leading impaired transmission. fewer than young, though severity synapse loss did not predict whether occurred or This work identifies novel mechanism dysfunction stratifies process by which regulated yet unknown warrants future investigation.

Язык: Английский

Процитировано

11
Astrocyte glypican 5 regulates synapse maturation and stabilization DOI

Alexandra P Bosworth,

Minerva Contreras, Laura Sancho

и другие.

Cell Reports, Год журнала: 2025, Номер 44(3), С. 115374 - 115374

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Neural representation of geoinformation in the human brain: affected by abstraction levels and spatial scales DOI Creative Commons
Tianyu Yang, Bo Zhao, Song Gao

и другие.

Annals of GIS, Год журнала: 2025, Номер unknown, С. 1 - 16

Опубликована: Апрель 6, 2025

Язык: Английский

Процитировано

0
Unsupervised classification of brain-wide axons reveals the presubiculum neuronal projection blueprint DOI Creative Commons
Diek W. Wheeler,

Shaina Banduri,

Sruthi Sankararaman

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Фев. 20, 2024

We present a quantitative strategy to identify all projection neuron types from given region with statistically different patterns of anatomical targeting. first validate the technique mouse primary motor cortex layer 6 data, yielding two clusters consistent cortico-thalamic and intra-telencephalic neurons. next analyze presubiculum, less-explored region, identifying five classes projecting neurons unique divergence, convergence, specificity. report several findings: individual target multiple subregions along defined functions; hypothalamic regions are exclusively targeted by same class also invading midbrain agranular retrosplenial cortex; Cornu Ammonis receives input single presubicular axons granular path distances presubiculum targets differ significantly between classes, as do distinct within most classes; identified have highly non-uniform abundances; somata topographically segregated among classes. This study thus demonstrates that projections shed light on functional organization their circuit.

Язык: Английский

Процитировано

2
Advanced Technologies in Clinical Research and Drug Development DOI
N. L. Swathi,

A. K. Hemanth Kumar

Advances in computational intelligence and robotics book series, Год журнала: 2024, Номер unknown, С. 1 - 17

Опубликована: Март 4, 2024

This chapter explores the synergistic potential of decentralized trials, gene editing (e.g., CRISPR-Cas9), and integration artificial intelligence (AI) machine learning (ML) in clinical trials drug development. Decentralized enhance diversity expedite timelines, while ensures precision treating genetic diseases, necessitating robust ethical guidelines. AI ML streamline processes, improving efficiency from patient recruitment to data analysis. Digital biomarkers real-time monitoring systems provide rich streams. confluence marks a transformative era, promoting patient-centric research, accelerating innovation, optimizing trial design. Ethical regulatory challenges require careful navigation. Integrating digital continuous will quality. synergy holds promise for personalized medicine improved outcomes, emphasizing need stakeholders balance innovation with responsibility optimal healthcare advancement.

Язык: Английский

Процитировано

2
The promise of the BRAIN initiative: NIH strategies for understanding neural circuit function DOI Creative Commons
Nina S. Hsu,

Hsiao Yu Fang,

Karen K. David

и другие.

Current Opinion in Neurobiology, Год журнала: 2020, Номер 65, С. 162 - 166

Опубликована: Дек. 1, 2020

New neurotechnologies fueled by the BRAIN Initiative now allow investigators to map, monitor and modulate complex neural circuits, enabling pursuit of research questions previously considered unapproachable. Yet it is convergence molecular neuroscience with new systems that promises greatest future advances. This particularly true for our understanding nervous system disorders, some which have known drivers or pathology but result in unknown perturbations circuit function. NIH-supported on “BRAIN Circuits” programs integrate experimental, analytic, theoretical capabilities analysis specific circuits their contributions perceptions, motivations, actions. In this review, we describe priority areas, review strategy balancing early feasibility mature projects, balance individual team science ‘BRAIN Circuits’ program. We also highlight diverse portfolio techniques, species, represented these projects.

Язык: Английский

Процитировано

16