Astrocytes and Tinnitus DOI Creative Commons
Paola Perin, Roberto Pizzala

Brain Sciences, Год журнала: 2024, Номер 14(12), С. 1213 - 1213

Опубликована: Ноя. 29, 2024

Tinnitus is correlated with anomalies of neural plasticity and has been found to be affected by inflammatory status. The current theories on tinnitus, although still somewhat incomplete, are based maladaptive mechanisms. Astrocytes play a major role in both responses inflammation regulation; moreover, they have recently discovered encode “context” for neuronal circuits, which similar the “expectation” Bayesian brain models. Therefore, this narrative review explores possible likely roles astrocytes mechanisms leading acute chronic tinnitus.

Язык: Английский

Extracellular vesicles: translational research and applications in neurology DOI
Apostolos Manolopoulos, Pamela J. Yao, Dimitrios Kapogiannis

и другие.

Nature Reviews Neurology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Язык: Английский

Процитировано

1

Neuron-to-glia and glia-to-glia signaling directs critical period experience-dependent synapse pruning DOI Creative Commons

Nichalas Nelson,

Vanessa Miller, Kendal Broadie

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Фев. 18, 2025

Experience-dependent glial synapse pruning plays a pivotal role in sculpting brain circuit connectivity during early-life critical periods of development. Recent advances suggest layered cascade intercellular communication between neurons and phagocytes orchestrates this precise, targeted elimination. We focus here on studies from the powerful Drosophila forward genetic model, with reference to complementary findings mouse work. present both neuron-to-glia glia-to-glia signaling pathways directing experience-dependent pruning. discuss putative hierarchy secreted long-distance cues cell surface short-distance that act sequentially orchestrate glia activation, infiltration, target recognition, engulfment, then phagocytosis for Ligand-receptor partners mediating these stages different contexts are discussed recent studies. Signaling include phospholipids, small neurotransmitters, insulin-like peptides, proteins. Conserved receptors ligands discussed, together mechanisms where receptor identity remains unknown. Potential proposed tight temporal-restriction heightened elimination periods, as well potential means re-open such plasticity at maturity.

Язык: Английский

Процитировано

0

Stem-Cell Derived Exosomal microRNAs as Biomarkers and Therapeutics for Pediatric Cardiovascular Disease DOI Creative Commons
Aaron H. Wasserman,

Bana Abolibdeh,

Reema Hamdan

и другие.

Current Treatment Options in Cardiovascular Medicine, Год журнала: 2025, Номер 27(1)

Опубликована: Апрель 9, 2025

In recent years, several pre-clinical studies have demonstrated the therapeutic potential of stem cell-derived exosomes in treatment cardiovascular disease (CVD). Here, we evaluate their as biomarkers for detection and monitoring CVD, with a particular focus on pediatric heart disease. Exosomes isolated from cell sources, including mesenchymal cells (MSCs) pluripotent (PSCs), benefit function, inflammatory responses, angiogenesis injured diseased hearts. These carry variety cargo, such proteins, lipids, nucleic acids. However, majority contain non-coding RNA molecules. Review existing literature RNAs relationship to CVD suggests that containing microRNAs (miRNAs) can serve promising due presence circulation, ease isolation, potential. are especially screening diagnostic tools early congenital

Язык: Английский

Процитировано

0

Regulation of synaptic mitochondria by extracellular vesicles and its implications for neuronal metabolism and synaptic plasticity DOI
Yuzhou Zeng, Anna Antoniou

Journal of Cerebral Blood Flow & Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Май 14, 2025

Mitochondrial metabolism in neurons is necessary for energetically costly processes like synaptic transmission and plasticity. As post-mitotic cells, are therefore faced with the challenge of maintaining healthy functioning mitochondria throughout lifetime. The precise mechanisms mitochondrial maintenance neurons, particularly morphologically complex dendrites axons, not fully understood. Evidence from several biological systems suggests regulation cellular by extracellular vesicles (EVs), secretory lipid-enclosed that have emerged as important mediators cell communication. In nervous system, neuronal glial EVs were shown to regulate circuit development function, at least part via transfer protein RNA cargo. Interestingly, been implicated diseases characterized altered metabolism, such cancer neurodegenerative diseases. Furthermore, system contain proteins related metabolic processes, even intact mitochondria. Here, we present current knowledge underlying maintenance, highlight recent evidence suggesting EVs. We further discuss potential implications EV-mediated function

Язык: Английский

Процитировано

0

Astrocytes and Tinnitus DOI Creative Commons
Paola Perin, Roberto Pizzala

Brain Sciences, Год журнала: 2024, Номер 14(12), С. 1213 - 1213

Опубликована: Ноя. 29, 2024

Tinnitus is correlated with anomalies of neural plasticity and has been found to be affected by inflammatory status. The current theories on tinnitus, although still somewhat incomplete, are based maladaptive mechanisms. Astrocytes play a major role in both responses inflammation regulation; moreover, they have recently discovered encode “context” for neuronal circuits, which similar the “expectation” Bayesian brain models. Therefore, this narrative review explores possible likely roles astrocytes mechanisms leading acute chronic tinnitus.

Язык: Английский

Процитировано

0