A neurometabolic mechanism involving dmPFC/dACC lactate in physical effort-based decision-making DOI Creative Commons
Nicolas Clairis,

Arthur Barakat,

Jules Brochard

и другие.

Molecular Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Авг. 30, 2024

Motivation levels vary across individuals, yet the underlying mechanisms driving these differences remain elusive. The dorsomedial prefrontal cortex/dorsal anterior cingulate cortex (dmPFC/dACC) and insula (aIns) play crucial roles in effort-based decision-making. Here, we investigate influence of lactate, a key metabolite involved energy metabolism signaling, on decisions involving both physical mental effort, as well its effects neural activation. Using proton magnetic resonance spectroscopy functional MRI 63 participants, find that higher lactate dmPFC/dACC are associated with reduced motivation for relationship mediated by activity within this region. Additionally, plasma correlate, suggesting systemic brain metabolism. Supported path analysis, our results highlight lactate's role modulator activity, hinting at neurometabolic mechanism integrates peripheral central metabolic states function

Язык: Английский

Meta-Reinforcement Learning reconciles surprise, value, and control in the anterior cingulate cortex DOI Creative Commons
Tim Vriens, Eliana Vassena, Giovanni Pezzulo

и другие.

PLoS Computational Biology, Год журнала: 2025, Номер 21(4), С. e1013025 - e1013025

Опубликована: Апрель 22, 2025

The role of the dorsal anterior cingulate cortex (dACC) in cognition is a frequently studied yet highly debated topic neuroscience. Most authors agree that dACC involved either cognitive control (e.g., voluntary inhibition automatic responses) or monitoring comparing expectations with outcomes, detecting errors, tracking surprise). A consensus on which theoretical perspective best explains contribution to behaviour still lacking, as two distinct sets studies report activation tasks requiring surprise for performance and without involving monitoring, respectively. This creates impasse, no single current account can reconcile these findings. Here we propose novel hypothesis function integrates both perspectives unifying, meta-Reinforcement Learning framework, optimized by meta-learning based Bayesian surprise. We tested quantitative predictions from our theory three different functional neuroimaging experiments at basis crisis. show successfully captures all results predicting functions, proposing solution crisis about within an integrative framework. In sum, suggest be framed optimisation control, providing its roles tracking, monitoring.

Язык: Английский

Процитировано

1
Understanding disrupted motivation in Parkinson’s disease through a value-based decision-making lens DOI
Campbell Le Heron, Lee‐Anne Morris, Sanjay Manohar

и другие.

Trends in Neurosciences, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
The Interplay Between Experimental Heat Pain and Noninvasive Stimulation of the Medial Prefrontal Cortex on Reinforcement Learning With Manipulated Outcome Contingencies DOI Open Access

Samy Mohammed Engebø Babiker,

Federica Luzzi,

Matthias Mittner

и другие.

European Journal of Neuroscience, Год журнала: 2025, Номер 61(7)

Опубликована: Март 31, 2025

ABSTRACT Pain negatively affects several cognitive abilities, but knowledge about its effect on reinforcement learning (RL) is limited. During RL, instrumental choices can be influenced by heuristic tendencies to approach rewards or inhibit actions when facing potentially aversive events, introducing “Pavlovian bias” in behavior. Recent studies suggest that compromised outcome controllability enhances Pavlovian bias, a phenomenon may linked suboptimal decision‐making learned helplessness (LH). Since LH common chronic pain syndromes, this study sought establish link between experimental heat (EHP), disrupted reward/loss contingencies, and RL performance healthy adults. In addition, we investigated if intermittent theta burst stimulation (iTBS) above the medial prefrontal/dorsal anterior cingulate cortex (mPFC/dACC) alleviates deleterious effects of EHP choice preregistered, 2 × between‐group, double‐blind ( N = 100), adult participants underwent three blocks an orthogonalized Go/NoGo task with two interleaved bouts active sham iTBS, either warm skin combined manipulated response–outcome contingency during task. Although did not impact response accuracy, it invigorated for rewards, reflecting enhanced bias. Whereas iTBS attenuated tendencies, was counteracted EHP, indicating antagonistic iTBS‐modulated mPFC activity Pavlovian–instrumental interactions. Surprisingly, exerted largely similar other latent parameters (go‐bias, rate, exploration) manner resembled LH. These findings shed light role mPFC/dACC LH‐like

Язык: Английский

Процитировано

0
A neurometabolic mechanism involving dmPFC/dACC lactate in physical effort-based decision-making DOI Creative Commons
Nicolas Clairis, Ahmed Barakat, Jules Brochard

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 4, 2024

Abstract Motivation levels vary across individuals, yet the underlying mechanisms driving these differences remain elusive. The dorsomedial prefrontal cortex/dorsal anterior cingulate cortex (dmPFC/dACC) and insula (aIns) play crucial roles in effort-based decision-making. Here, we investigate influence of lactate, a key metabolite involved energy metabolism signaling, on decisions involving both physical mental effort, as well its effects neural activation. Using proton magnetic resonance spectroscopy functional MRI 63 participants, find that higher lactate dmPFC/dACC are associated with reduced motivation for relationship mediated by activity within this region. Additionally, plasma correlate, suggesting systemic brain metabolism. Supported path analysis, our results highlight lactate’s role modulator activity, hinting at neurometabolic mechanism integrates peripheral central metabolic states function

Язык: Английский

Процитировано

1
Unifying Effort DOI Open Access
Malte Hendrickx

Опубликована: Май 12, 2024

At first glance, the type of effort required to solve a chess puzzle and run marathon seem fundamentally different. This paper argues that’s wrong. I present novel "mental-effort first" account in which all is mental nature. outline psychological mechanisms behind choice execution, emphasizing role cognitive control, process by efforts–mental bodily–are selected enacted. five arguments that convergently provide strong support for mental-effort account. Additionally, examine implications this unified theory philosophical discussions ethics, philosophy mind, action theory.

Язык: Английский

Процитировано

1
A neurometabolic mechanism involving dmPFC/dACC lactate in physical effort-based decision-making DOI Creative Commons
Nicolas Clairis,

Arthur Barakat,

Jules Brochard

и другие.

Molecular Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Авг. 30, 2024

Motivation levels vary across individuals, yet the underlying mechanisms driving these differences remain elusive. The dorsomedial prefrontal cortex/dorsal anterior cingulate cortex (dmPFC/dACC) and insula (aIns) play crucial roles in effort-based decision-making. Here, we investigate influence of lactate, a key metabolite involved energy metabolism signaling, on decisions involving both physical mental effort, as well its effects neural activation. Using proton magnetic resonance spectroscopy functional MRI 63 participants, find that higher lactate dmPFC/dACC are associated with reduced motivation for relationship mediated by activity within this region. Additionally, plasma correlate, suggesting systemic brain metabolism. Supported path analysis, our results highlight lactate's role modulator activity, hinting at neurometabolic mechanism integrates peripheral central metabolic states function

Язык: Английский

Процитировано

1