Representation and control of pain and itch by distinct prefrontal neural ensembles
Neuron,
Год журнала:
2023,
Номер
111(15), С. 2414 - 2431.e7
Опубликована: Май 23, 2023
Язык: Английский
Endogenous opiates and behavior: 2023
Peptides,
Год журнала:
2024,
Номер
179, С. 171268 - 171268
Опубликована: Июнь 28, 2024
Язык: Английский
An insular cortical circuit required for itch sensation and aversion
Current Biology,
Год журнала:
2024,
Номер
34(7), С. 1453 - 1468.e6
Опубликована: Март 13, 2024
Язык: Английский
Prelimbic cortex-nucleus accumbens core projection positively regulates itch and itch-related aversion
Behavioural Brain Research,
Год журнала:
2024,
Номер
468, С. 114999 - 114999
Опубликована: Апрель 13, 2024
Язык: Английский
The projection from the prelimbic cortex to the ventral tegmental area negatively regulates 5-HT-induced itch-scratching and positively regulates itch-related aversion in rats
Brain Research Bulletin,
Год журнала:
2025,
Номер
223, С. 111283 - 111283
Опубликована: Фев. 28, 2025
Язык: Английский
Pruritus and anxiety symptoms in chronic spontaneous urticaria are associated with altered functional connectivity of the brain
Journal of Neuroradiology,
Год журнала:
2025,
Номер
52(4), С. 101355 - 101355
Опубликована: Май 30, 2025
Язык: Английский
Activation of pyramidal neurons in the infralimbic cortex alleviates LPS-induced depressive-like behavior in mice
Brain Research Bulletin,
Год журнала:
2024,
Номер
214, С. 111008 - 111008
Опубликована: Июнь 10, 2024
The
infralimbic
(IL)
cortex
dysfunction
has
been
implicated
in
major
depressive
disorder
(MDD),
yet
the
precise
cellular
and
molecular
mechanisms
remain
poorly
understood.
In
this
study,
we
investigated
role
of
layer
V
pyramidal
neurons
a
mouse
model
MDD
induced
by
repeated
lipopolysaccharide
(LPS)
administration.
Our
results
demonstrate
that
three
days
systemic
LPS
administration
depressive-like
behavior
upregulated
mRNA
levels
interleukin-1β
(IL-1β),
tumor
necrosis
factor-alpha
(TNF-α),
transforming
growth
factor-β
(TGF-β)
IL
cortex.
Electrophysiological
recordings
revealed
significant
decrease
intrinsic
excitability
following
exposure.
Importantly,
chemogenetic
activation
ameliorated
LPS-induced
behavior.
Additionally,
significantly
increased
microglial
activity
IL,
as
evidenced
greater
number
Ionized
calcium
binding
adaptor
molecule-1
(IBA-1)-positive
cells.
Morphometric
analysis
further
unveiled
enlarged
soma,
decreased
branch
numbers,
shorter
lengths
cells
Moreover,
clozapine-N-oxide
microglia
length
but
did
not
change
or
cytosolic
area.
These
collectively
suggest
targeted
mitigates
response
ameliorates
behaviors
Therefore,
our
findings
offer
potential
therapeutic
targets
for
development
interventions
aimed
at
alleviating
symptoms
modulating
cortical
circuitry
activity.
Язык: Английский
Dopamine Release Dynamics in the Nucleus Accumbens Are Modulated by the Timing of Electrical Stimulation Pulses When Applied to the Medial Forebrain Bundle and Medial Prefrontal Cortex
ACS Chemical Neuroscience,
Год журнала:
2024,
Номер
15(14), С. 2643 - 2653
Опубликована: Июль 3, 2024
Electrical
brain
stimulation
has
been
used
in
vivo
and
vitro
to
investigate
neural
circuitry.
Historically,
parameters
such
as
amplitude,
frequency,
pulse
width
were
varied
their
effects
on
neurotransmitter
release
behavior.
These
experiments
have
traditionally
employed
fixed-frequency
patterns,
but
it
previously
found
that
neurons
are
more
precisely
tuned
variable
input.
Introducing
variability
into
the
interpulse
interval
of
pulses
will
inform
how
dopaminergic
can
be
modulated
by
timing.
Here,
rats
is
monitored
nucleus
accumbens
(NAc),
a
key
center
which
plays
role
learning
motivation,
fast-scan
cyclic
voltammetry.
Dopaminergic
NAc
could
also
region
due
differences
connectivity.
We
targeted
two
regions
for
stimulation─the
medial
forebrain
bundle
(MFB)
prefrontal
cortex
(mPFC)─due
involvement
reward
processing
projections
NAc.
Our
goal
patterns
delivered
these
affect
time
course
dopamine
stimulating
MFB
with
saw
highly
responsive,
frequency-driven
response.
In
contrast,
applied
mPFC
not
sensitive
frequency
changes.
This
work
help
specifically
improve
efficiency
electrical
control
release.
Язык: Английский