Dopamine Release Dynamics in the Nucleus Accumbens Are Modulated by the Timing of Electrical Stimulation Pulses When Applied to the Medial Forebrain Bundle and Medial Prefrontal Cortex DOI

Andrea R. Hamilton,

Abhilasha Vishwanath, Nathan C. Weintraub

и другие.

ACS Chemical Neuroscience, Год журнала: 2024, Номер 15(14), С. 2643 - 2653

Опубликована: Июль 3, 2024

Electrical brain stimulation has been used in vivo and vitro to investigate neural circuitry. Historically, parameters such as amplitude, frequency, pulse width were varied their effects on neurotransmitter release behavior. These experiments have traditionally employed fixed-frequency patterns, but it previously found that neurons are more precisely tuned variable input. Introducing variability into the interpulse interval of pulses will inform how dopaminergic can be modulated by timing. Here, rats is monitored nucleus accumbens (NAc), a key center which plays role learning motivation, fast-scan cyclic voltammetry. Dopaminergic NAc could also region due differences connectivity. We targeted two regions for stimulation─the medial forebrain bundle (MFB) prefrontal cortex (mPFC)─due involvement reward processing projections NAc. Our goal patterns delivered these affect time course dopamine stimulating MFB with saw highly responsive, frequency-driven response. In contrast, applied mPFC not sensitive frequency changes. This work help specifically improve efficiency electrical control release.

Язык: Английский

Representation and control of pain and itch by distinct prefrontal neural ensembles DOI Creative Commons
Qian Pan,

Su-Shan Guo,

Ming Chen

и другие.

Neuron, Год журнала: 2023, Номер 111(15), С. 2414 - 2431.e7

Опубликована: Май 23, 2023

Язык: Английский

Процитировано

25

Endogenous opiates and behavior: 2023 DOI
Richard J. Bodnar

Peptides, Год журнала: 2024, Номер 179, С. 171268 - 171268

Опубликована: Июнь 28, 2024

Язык: Английский

Процитировано

7

An insular cortical circuit required for itch sensation and aversion DOI

Jieyan Zheng,

Xiao Min Zhang,

Wenting Tang

и другие.

Current Biology, Год журнала: 2024, Номер 34(7), С. 1453 - 1468.e6

Опубликована: Март 13, 2024

Язык: Английский

Процитировано

4

Prelimbic cortex-nucleus accumbens core projection positively regulates itch and itch-related aversion DOI

Jun-hui Long,

Pujun Wang, Xuan Li

и другие.

Behavioural Brain Research, Год журнала: 2024, Номер 468, С. 114999 - 114999

Опубликована: Апрель 13, 2024

Язык: Английский

Процитировано

3

The projection from the prelimbic cortex to the ventral tegmental area negatively regulates 5-HT-induced itch-scratching and positively regulates itch-related aversion in rats DOI Creative Commons
Xingyu Lu,

Jun-Fei Teng,

Juan Yao

и другие.

Brain Research Bulletin, Год журнала: 2025, Номер 223, С. 111283 - 111283

Опубликована: Фев. 28, 2025

Язык: Английский

Процитировано

0

Pruritus and anxiety symptoms in chronic spontaneous urticaria are associated with altered functional connectivity of the brain DOI
Ying Zhao, Yang Han, Siyi Yu

и другие.

Journal of Neuroradiology, Год журнала: 2025, Номер 52(4), С. 101355 - 101355

Опубликована: Май 30, 2025

Язык: Английский

Процитировано

0

Activation of pyramidal neurons in the infralimbic cortex alleviates LPS-induced depressive-like behavior in mice DOI Creative Commons
Pengfei Zhang,

Wen-Yong You,

Yong‐Jing Gao

и другие.

Brain Research Bulletin, Год журнала: 2024, Номер 214, С. 111008 - 111008

Опубликована: Июнь 10, 2024

The infralimbic (IL) cortex dysfunction has been implicated in major depressive disorder (MDD), yet the precise cellular and molecular mechanisms remain poorly understood. In this study, we investigated role of layer V pyramidal neurons a mouse model MDD induced by repeated lipopolysaccharide (LPS) administration. Our results demonstrate that three days systemic LPS administration depressive-like behavior upregulated mRNA levels interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α), transforming growth factor-β (TGF-β) IL cortex. Electrophysiological recordings revealed significant decrease intrinsic excitability following exposure. Importantly, chemogenetic activation ameliorated LPS-induced behavior. Additionally, significantly increased microglial activity IL, as evidenced greater number Ionized calcium binding adaptor molecule-1 (IBA-1)-positive cells. Morphometric analysis further unveiled enlarged soma, decreased branch numbers, shorter lengths cells Moreover, clozapine-N-oxide microglia length but did not change or cytosolic area. These collectively suggest targeted mitigates response ameliorates behaviors Therefore, our findings offer potential therapeutic targets for development interventions aimed at alleviating symptoms modulating cortical circuitry activity.

Язык: Английский

Процитировано

1

Dopamine Release Dynamics in the Nucleus Accumbens Are Modulated by the Timing of Electrical Stimulation Pulses When Applied to the Medial Forebrain Bundle and Medial Prefrontal Cortex DOI

Andrea R. Hamilton,

Abhilasha Vishwanath, Nathan C. Weintraub

и другие.

ACS Chemical Neuroscience, Год журнала: 2024, Номер 15(14), С. 2643 - 2653

Опубликована: Июль 3, 2024

Electrical brain stimulation has been used in vivo and vitro to investigate neural circuitry. Historically, parameters such as amplitude, frequency, pulse width were varied their effects on neurotransmitter release behavior. These experiments have traditionally employed fixed-frequency patterns, but it previously found that neurons are more precisely tuned variable input. Introducing variability into the interpulse interval of pulses will inform how dopaminergic can be modulated by timing. Here, rats is monitored nucleus accumbens (NAc), a key center which plays role learning motivation, fast-scan cyclic voltammetry. Dopaminergic NAc could also region due differences connectivity. We targeted two regions for stimulation─the medial forebrain bundle (MFB) prefrontal cortex (mPFC)─due involvement reward processing projections NAc. Our goal patterns delivered these affect time course dopamine stimulating MFB with saw highly responsive, frequency-driven response. In contrast, applied mPFC not sensitive frequency changes. This work help specifically improve efficiency electrical control release.

Язык: Английский

Процитировано

0