bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 5, 2023
Abstract
Hemispheric
brain
asymmetry
is
a
basic
organizational
principle
of
the
human
and
has
been
implicated
in
various
psychiatric
conditions,
including
autism
spectrum
disorder.
Brain
not
uniquely
feature
observed
other
species
such
as
mouse.
Yet,
patterns
are
generally
nuanced,
substantial
sample
sizes
required
to
detect
these
patterns.
In
this
pre-registered
study,
we
use
mouse
dataset
from
Province
Ontario
Neurodevelopmental
Network,
which
comprises
structural
MRI
data
over
2000
mice,
genetic
models
for
disorder,
reveal
scope
magnitude
hemispheric
Our
findings
demonstrate
presence
robust
brain,
larger
right
volumes
towards
anterior
pole
left
toward
posterior
pole,
opposite
what
shown
humans.
This
suggests
existence
species-specific
traits.
Further
clustering
analysis
identified
distinct
disorder
models,
phenomenon
that
also
seen
atypically
developing
participants.
study
shows
potential
studying
biological
bases
typical
atypical
but
warrants
caution
seem
differ
between
humans
mice.
Redox Biology,
Год журнала:
2023,
Номер
65, С. 102821 - 102821
Опубликована: Июль 20, 2023
Stress-induced
release
of
glucocorticoid
is
an
important
amyloidogenic
factor
that
upregulates
amyloid
precursor
protein
(APP)
and
β
secretase
1
(BACE1)
levels.
Glucocorticoid
also
contributes
to
the
pathogenesis
Alzheimer's
disease
(AD)
by
increasing
ER-mitochondria
connectivity,
in
which
(Aβ)
processing
occurs
rigorously
because
its
lipid
raft-rich
characteristics.
However,
mechanism
enhances
γ-secretase
activity
mitochondrial-associated
membrane
ER
(MAM)
subsequent
accumulation
mitochondrial
Aβ
unclear.
In
this
study,
we
determined
how
production
MAM
using
SH-SY5Y
cells
ICR
mice.
First,
observed
cortisol-induced
mitochondria
preceded
extracellular
apposition
enhancing
activity,
was
result
increased
presenilin
(PSEN1)
localization
MAM.
Screening
data
revealed
cortisol
selectively
downregulated
retrieval
Rer1,
triggered
maturation
entry
into
endocytic
secretory
pathway
PSEN1.
Accordingly,
overexpression
RER1
reversed
deleterious
effects
on
respiratory
function
neuronal
cell
viability.
Notably,
found
guided
receptor
(GR)
bind
directly
promoter,
thus
trans-repressing
expression.
Inhibiting
GR
reduced
at
improved
outcome
a
spatial
memory
task
mice
exposed
corticosterone.
Taken
together,
PSEN1-mediated
generation
downregulating
potential
target
early
stages
AD
pathogenesis.
Journal of Neuroscience,
Год журнала:
2024,
Номер
44(34), С. e0228242024 - e0228242024
Опубликована: Июль 18, 2024
Neuropeptide
Y
(NPY)
increases
resilience
and
buffers
behavioral
stress
responses
in
male
rats
part
through
decreasing
the
excitability
of
principal
output
neurons
basolateral
amygdala
(BLA).
Intra-BLA
administration
NPY
acutely
social
interaction
(SI)
activation
either
Neurobiology of Stress,
Год журнала:
2024,
Номер
32, С. 100665 - 100665
Опубликована: Авг. 10, 2024
With
the
recent
rise
in
rate
of
alcohol
use
disorder
(AUD)
women,
historical
gap
between
men
and
women
living
with
this
condition
is
narrowing.
While
there
are
many
commonalities
how
impacted
by
AUD,
an
accumulating
body
evidence
revealing
sex-dependent
adaptations
that
may
require
distinct
therapeutic
approaches.
Preclinical
rodent
studies
beginning
to
shed
light
on
sex
differences
effects
chronic
exposure
synaptic
activity
a
number
brain
regions.
Prior
from
our
laboratory
revealed
that,
while
withdrawal
intermittent
ethanol
(CIE),
commonly
used
model
increased
excitability
ventral
hippocampus
(vHC)
male
rats,
same
treatment
had
opposite
effect
females.
A
follow-up
study
not
only
expanded
mechanisms
these
findings
but
also
established
CIE-dependent
increase
excitatory-inhibitory
(E-I)
balance
glutamatergic
projection
basolateral
amygdala
vHC
(BLA-vHC).
This
pathway
modulates
anxiety-like
behavior
could
help
explain
comorbid
occurrence
anxiety
disorders
individuals
suffering
AUD.
The
present
sought
conduct
similar
analysis
CIE
both
BLA-vHC
female
rats.
Our
indicate
increases
strength
inhibitory
neurotransmission
sex-specific
adaptation
blocks,
or
at
least
delays,
intrinsic
transmission
observed
males.
establish
as
important
circuitry
consider
for
future
directed
identifying
approaches
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 5, 2023
Abstract
Hemispheric
brain
asymmetry
is
a
basic
organizational
principle
of
the
human
and
has
been
implicated
in
various
psychiatric
conditions,
including
autism
spectrum
disorder.
Brain
not
uniquely
feature
observed
other
species
such
as
mouse.
Yet,
patterns
are
generally
nuanced,
substantial
sample
sizes
required
to
detect
these
patterns.
In
this
pre-registered
study,
we
use
mouse
dataset
from
Province
Ontario
Neurodevelopmental
Network,
which
comprises
structural
MRI
data
over
2000
mice,
genetic
models
for
disorder,
reveal
scope
magnitude
hemispheric
Our
findings
demonstrate
presence
robust
brain,
larger
right
volumes
towards
anterior
pole
left
toward
posterior
pole,
opposite
what
shown
humans.
This
suggests
existence
species-specific
traits.
Further
clustering
analysis
identified
distinct
disorder
models,
phenomenon
that
also
seen
atypically
developing
participants.
study
shows
potential
studying
biological
bases
typical
atypical
but
warrants
caution
seem
differ
between
humans
mice.
