Segregated input to thalamic areas which project differently to core and shell auditory cortical fields (15 words)

iScience, Год журнала: 2025, Номер 28(2), С. 111721 - 111721

Опубликована: Янв. 1, 2025

Perception of the environment is multimodal in nature, with sensory systems intricately interconnected. The ability to integrate sensations while preserving distinct characteristics each modality crucial, and underlying mechanisms organization that facilitate this process require further elucidation. In auditory system, although concept core shell pathways well established, brain-wide input/output relationships thalamic regions projecting auditory-responsive cortical areas remain insufficiently studied, particularly relation non-auditory structures. study, we utilized functional imaging viral tracing techniques map connections pathways. We identified three pathways, addition a pathway, exhibiting unique associations structures involved behavior, emotion, other functions. This architecture suggests these contribute differentially various aspects integration.

Язык: Английский

Two Prediction Error Systems in the Nonlemniscal Inferior Colliculus: Spectral and Nonspectral

Journal of Neuroscience, Год журнала: 2024, Номер 44(23), С. e1420232024 - e1420232024

Опубликована: Апрель 16, 2024

According to the predictive processing framework, perception emerges from reciprocal exchange of predictions and prediction errors (PEs) between hierarchically organized neural circuits. The nonlemniscal division inferior colliculus (IC) is earliest source auditory PE signals, but their neuronal generators, properties, functional relevance have remained mostly undefined. We recorded single-unit mismatch responses oddball stimulation at different intensities, together with activity evoked by two sequences alternating tones control frequency-specific effects. Our results reveal a differential treatment unpredictable many-standards predictable cascade lemniscal IC neurons that not present in thalamus or cortex. Furthermore, we found frequency response areas reflect role subcortical processing, distinguishing three hierarchical levels: (1) sharply tuned receptive fields exhibit mild repetition suppression without signaling PEs, thereby constituting input level local circuitry. (2) Neurons broadly form main, spectral system, which provides dynamic gain compensation near-threshold unexpected sounds. This early enhancement saliency reliant on features was observed (3) Untuned an accessory, nonspectral reports all surprising deviances robust consistent manner, resembling These show unstructured unstable could result inhibitory controlled corticofugal projections conveying top-down predictions.

Язык: Английский

The lateral thalamus: a bridge between multisensory processing and naturalistic behaviors

Trends in Neurosciences, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский