Annals of the New York Academy of Sciences,
Год журнала:
2011,
Номер
1216(1), С. 99 - 113
Опубликована: Янв. 1, 2011
Drug‐induced
alterations
in
gene
expression
throughout
the
reward
circuitry
of
brain
are
likely
components
persistence
drug‐addicted
state.
Recent
studies
examining
molecular
mechanisms
controlling
drug‐induced
transcriptional,
behavioral,
and
synaptic
plasticity
have
indicated
a
direct
role
for
chromatin
remodeling
regulation
stability
drug‐mediated
neuronal
programs,
subsequent
promulgation
addictive
behaviors.
In
this
review,
we
discuss
recent
advances
our
understanding
phenomena—or
epigenetics,
by
one
definition—that
contribute
to
drug
addiction,
with
hope
that
such
mechanistic
insights
may
aid
development
novel
therapeutics
future
treatments
addiction.
Physiological Reviews,
Год журнала:
2011,
Номер
91(2), С. 603 - 649
Опубликована: Апрель 1, 2011
Over
the
past
decade,
it
has
become
increasingly
obvious
that
epigenetic
mechanisms
are
an
integral
part
of
a
multitude
brain
functions
range
from
development
nervous
system
over
basic
neuronal
to
higher
order
cognitive
processes.
At
same
time,
substantial
body
evidence
surfaced
indicating
several
neurodevelopmental,
neurodegenerative,
and
neuropsychiatric
disorders
in
caused
by
aberrant
modifications.
Because
their
inherent
plasticity,
such
pathological
modifications
readily
amenable
pharmacological
interventions
have
thus
raised
justified
hopes
machinery
provides
powerful
new
platform
for
therapeutic
approaches
against
these
diseases.
In
this
review,
we
give
detailed
overview
implication
both
physiological
processes
summarize
state-of-the-art
“epigenetic
medicine”
where
applicable.
Despite,
or
because
of,
exciting
findings,
is
becoming
apparent
highly
complex
intertwined,
which
underscores
need
more
refined
studies
disentangle
brain-region
cell-type
specific
codes
given
environmental
condition.
Clearly,
contains
“hotspot”
with
unique
potential
not
only
better
understand
its
most
functions,
but
also
treat
vicious
Biochimie,
Год журнала:
2012,
Номер
94(11), С. 2193 - 2201
Опубликована: Апрель 28, 2012
Post-translation
modifications
of
histones
modulate
the
accessibility
and
transcriptional
competence
specific
chromatin
regions
within
eukaryotic
genome.
Phosphorylation
histone
H3
is
unique
in
sense
that
it
associates
on
one
hand
with
open
during
gene
activation
marks
other
highly
condensed
mitosis.
serine
residues
at
a
dynamic
process
creates
together
acetylation
methylation
neighboring
lysine
combinatorial
patterns
are
read
by
detector
proteins.
In
this
review
we
describe
importance
different
phosphorylation
for
condensation
addition,
signals
trigger
factors
control
reversible
modification
interphase
mediate
biological
readout
signal.
Finally,
discuss
models
describing
role
transcription
poised
genes
or
transient
derepression
epigenetically
silenced
genes.
We
propose
context
might
temporarily
relieve
silencing
without
affecting
epigenetic
memory.
Annual Review of Biochemistry,
Год журнала:
2022,
Номер
91(1), С. 505 - 540
Опубликована: Март 19, 2022
Mitogen-activated
protein
kinase
(MAPK)-activated
kinases
(MAPKAPKs)
are
defined
by
their
exclusive
activation
MAPKs.
They
can
be
activated
classical
and
atypical
MAPKs
that
have
been
stimulated
mitogens
various
stresses.
Genetic
deletions
of
MAPKAPKs
availability
highly
specific
small-molecule
inhibitors
continuously
increased
our
functional
understanding
these
kinases.
cooperate
in
the
regulation
gene
expression
at
level
transcription;
RNA
processing,
export,
stability;
synthesis.
The
diversity
stimuli
for
MAPK
activation,
crosstalk
between
different
MAPKAPKs,
substrate
pattern
orchestrate
immediate-early
inflammatory
responses
space
time
ensure
proper
control
cell
growth,
differentiation,
behavior.
Hence,
promising
targets
cancer
therapy
treatments
conditions
acute
chronic
inflammation,
such
as
cytokine
storms
rheumatoid
arthritis.
Proceedings of the National Academy of Sciences,
Год журнала:
2006,
Номер
103(8), С. 2932 - 2937
Опубликована: Фев. 10, 2006
Repeated
association
of
drugs
abuse
with
context
leads
to
long-lasting
behavioral
responses
that
reflect
reward-controlled
learning
and
participate
in
the
establishment
addiction.
Reactivation
consolidated
memories
is
known
produce
a
reconsolidation
process
during
which
undergo
labile
state.
We
investigated
whether
reexposure
had
similar
effects.
Cocaine
administration
activates
extracellular
signal-regulated
kinase
(ERK)
striatum,
ERK
activation
required
for
acquisition
cocaine-induced
conditioned
place
preference
(CPP).
When
mice
previously
cocaine-place
were
reexposed
cocaine
drug-paired
compartment
after
systemic
SL327,
an
inhibitor
activation,
CPP
response
was
abolished
24
h
later.
This
procedure
also
phosphorylation
glutamate
receptor-1
observed
ventral
dorsal
later,
test.
Erasure
by
SL327
combination
did
not
result
from
enhanced
extinction.
Similarly,
morphine
presence
long-lastingly
learned
morphine-CPP.
The
effects
on
cocaine-
or
morphine-CPP
reproduced
protein
synthesis
inhibition.
In
contrast,
inhibition
alter
acquired
locomotor
sensitization
cocaine.
Our
findings
show
established
can
be
disrupted
when
reactivation
associates
both
drug
administration.
involves
ERK,
treatment
preventing
erases
response.
These
results
suggest
potential
therapeutic
strategies
explore
