The Transdiagnostic Connectome Project: a richly phenotyped open dataset for advancing the study of brain-behavior relationships in psychiatry DOI Creative Commons
Sidhant Chopra, Carrisa Cocuzza,

Connor Lawhead

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 21, 2024

An important aim in psychiatry is the establishment of valid and reliable associations linking profiles brain functioning to clinically relevant symptoms behaviors across patient populations. To advance progress this area, we introduce an open dataset containing behavioral neuroimaging data from 241 individuals aged 18 70, comprising 148 meeting diagnostic criteria for a broad range psychiatric illnesses healthy comparison group 93 individuals. These include high-resolution anatomical scans, multiple resting-state, task-based functional MRI runs. Additionally, participants completed over 50 psychological cognitive assessments. Here, detail available as well raw processed derivatives. Associations between processing quality metrics, such head motion, are reported. Processed exhibit classic task activation effects canonical network organization. Overall, provide comprehensive analysis-ready transdiagnostic dataset, which hope will accelerate identification illness-relevant features functioning, enabling future discoveries basic clinical neuroscience.

Язык: Английский

Task fMRI paradigms may capture more behaviorally relevant information than resting-state functional connectivity DOI Creative Commons
Weiqi Zhao, Carolina Makowski, Donald J. Hagler

и другие.

NeuroImage, Год журнала: 2023, Номер 270, С. 119946 - 119946

Опубликована: Фев. 17, 2023

Characterizing the optimal fMRI paradigms for detecting behaviorally relevant functional connectivity (FC) patterns is a critical step to furthering our knowledge of neural basis behavior. Previous studies suggested that FC derived from task paradigms, which we refer as task-based FC, are better correlated with individual differences in behavior than resting-state but consistency and generalizability this advantage across conditions was not fully explored. Using data three tasks Adolescent Brain Cognitive Development Study ® (ABCD), tested whether observed improvement behavioral prediction power can be attributed changes brain activity induced by design. We decomposed time course each into model fit (the fitted condition regressors single-subject general linear model) residuals, calculated their respective compared performance these estimates original FC. The residual at predicting measure cognitive ability or two measures on tasks. superior content-specific insofar it only probed similar constructs predicted interest. To surprise, parameters, beta regressors, were equally if more predictive all measures. These results showed afforded largely driven associated Together previous studies, findings highlighted importance design eliciting meaningful activation patterns.

Язык: Английский

Процитировано

79

A shared neural basis underlying psychiatric comorbidity DOI Creative Commons
Chao Xie, Shitong Xiang, Chun Shen

и другие.

Nature Medicine, Год журнала: 2023, Номер 29(5), С. 1232 - 1242

Опубликована: Апрель 24, 2023

Abstract Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) define neuropsychopathological (NP) across externalizing internalizing symptoms using multitask connectomes. We demonstrate that NP might represent unified, genetically determined, delayed development of the prefrontal cortex further leads poor executive function. also show be reproducible in multiple developmental periods, preadolescence early adulthood, generalizable resting-state connectome clinical samples (the ADHD-200 Sample STRATIFY & ESTRA Project). conclusion, identify neural basis mental health disorders, bridging multidimensional evidence behavioral, genetic substrates. These findings may help develop new therapeutic interventions for comorbidities.

Язык: Английский

Процитировано

55

Functional Connectivity of the Cognitive Cerebellum DOI Creative Commons
Christophe Habas

Frontiers in Systems Neuroscience, Год журнала: 2021, Номер 15

Опубликована: Апрель 8, 2021

Anatomical tracing, human clinical data, and stimulation functional imaging have firmly established the major role of (neo-)cerebellum in cognition emotion. Telencephalization characterized by great expansion associative cortices, especially prefrontal one, has been associated with parallel neocerebellar cortex, lobule VII, an increased number interconnections between these two cortical structures. These anatomical modifications underlie implication neocerebellum cognitive control complex motor non-motor tasks. In humans, resting state connectivity used to determine a thorough anatomo-functional parcellation neocerebellum. This technique identified central networks involving subserving its function. Neocerebellum participates all intrinsic connected such as executive, default mode, salience, dorsal ventral attentional, language-dedicated networks. The executive network constitutes main circuit represented within cortex. Cerebellar zones devoted appear multiple, interdigitated, spatially ordered three gradients. Such organization enables monitor synchronize involved emotion, likely computing internal models.

Язык: Английский

Процитировано

98

From neurotransmitters to networks: Transcending organisational hierarchies with molecular-informed functional imaging DOI Creative Commons
Timothy Lawn, Matthew A. Howard, Federico Turkheimer

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 150, С. 105193 - 105193

Опубликована: Апрель 21, 2023

The human brain exhibits complex interactions across micro, meso-, and macro-scale organisational principles. Recent synergistic multi-modal approaches have begun to link micro-scale information systems level dynamics, transcending hierarchies offering novel perspectives into the brain's function dysfunction. Specifically, distribution of properties (such as receptor density or gene expression) can be mapped onto measures from functional MRI provide neurobiological insights. Methodological enrich imaging analyses with molecular are rapidly evolving, several streams research having developed relatively independently, each unique potential explore trans-hierarchical functioning brain. Here, we address three principal - spatial correlation, molecular-enriched network, in-silico whole modelling a critical overview different sources information, how this utilised within fMRI data, merits pitfalls methodology, and, through use key examples, highlight their promise shed new light on domains neuroscientific inquiry.

Язык: Английский

Процитировано

28

Selective recruitment of the cerebellum evidenced by task-dependent gating of inputs DOI Creative Commons
Ladan Shahshahani, Maedbh King, Caroline Nettekoven

и другие.

eLife, Год журнала: 2024, Номер 13

Опубликована: Апрель 5, 2024

Functional magnetic resonance imaging (fMRI) studies have documented cerebellar activity across a wide array of tasks. However, the functional contribution cerebellum within these task domains remains unclear because is often studied in isolation. This problematic, as fMRI may simply reflect transmission neocortical through fixed connections. Here, we present new approach that addresses this problem. Rather than focus on task-dependent changes alone, ask if inputs to are gated manner. We hypothesize input upregulated when functionally contributes task. first validated using finger movement task, where integrity has been shown be essential for coordination rapid alternating movements but not force generation. While both and increased with increasing speed force, speed-related were larger predicted by an optimized cortico-cerebellar connectivity model. then applied same cognitive domain, assessing how supports working memory. Enhanced gating was associated encoding items memory, manipulation or retrieval items. Focusing offers promising understand specific contributions function.

Язык: Английский

Процитировано

9

Effects of tactile feedback in post-stroke hand rehabilitation on functional connectivity and cortical activation: an fNIRS study DOI Creative Commons
Lingling Chen, Fangang Meng, Congcong Huo

и другие.

Biomedical Optics Express, Год журнала: 2025, Номер 16(2), С. 643 - 643

Опубликована: Янв. 6, 2025

Stroke-induced hand motor impairments have a significant impact on the daily lives of patients. Motor rehabilitation with tactile feedback (TF) shows promise as an effective intervention; however, its neural mechanisms are still not fully understood. The main objective this study was to examine effect brain functional responses during single movement session in post-stroke patients, using near-infrared spectroscopy (fNIRS). changes oxy- and deoxy-hemoglobin concentrations were recorded from bilateral prefrontal, motor, occipital areas 13 patients subacute recovery phase 15 healthy controls hand-grasping task TF no-TF. cortical activation responses, connectivity, network properties calculated explore specific response two grasping tasks. results showed that exhibited increased hemodynamic cortex tasks TF. However, prefrontal cortex, left sensorimotor right premotor area significantly lower compared (p < 0.05). Additionally, poorer overall function, reductions both clustering coefficient = 0.0016), reflecting local information transfer efficiency, transitivity 0.0053), representing global integration. A positive correlation observed between grip strength metrics (r 0.592, p 0.033), well 0.590, 0.034) indicating greater associated reduced transmission efficiency. These findings indicated can modulate activity learning integration, providing evidence for potential valuable tool stroke rehabilitation.

Язык: Английский

Процитировано

1

Investigating dynamic brain functional redundancy as a mechanism of cognitive reserve DOI Creative Commons
Julia Schwarz,

Franziska Zistler,

Adriana Usheva

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17

Опубликована: Фев. 4, 2025

Introduction Individuals with higher cognitive reserve (CR) are thought to be more resilient the effects of age-related brain changes on performance. A potential mechanism CR is redundancy in network functional connectivity (BFR), which refers amount time spends a redundant state, indicating presence multiple independent pathways between regions. These can serve as back-up information processing routes, providing resiliency stress or disease. In this study we aimed investigate whether BFR modulates association and performance across broad range domains. Methods An open-access neuroimaging behavioral dataset ( n = 301 healthy participants, 18–89 years) was analyzed. Cortical gray matter (GM) volume, cortical thickness age, extracted from structural T1 images, served our measures life-course related (BC). Cognitive scores were principal component analysis performed 13 tests Multivariate linear regression tested modulating effect relationship Results PCA revealed three test components episodic, semantic executive functioning. Increased predicted reduced episodic functioning when considering GM volume BC. significantly modulated We found neither predictive nor performance, significant defining BC via age. Discussion Our results suggest that could metric certain domains, specifically functioning, defined dimensions findings potentially indicate underlying mechanisms CR.

Язык: Английский

Процитировано

1

A simple clustering approach to map the human brain's cortical semantic network organization during task DOI Creative Commons
Yunhao Zhang, Shaonan Wang, Nan Lin

и другие.

NeuroImage, Год журнала: 2025, Номер unknown, С. 121096 - 121096

Опубликована: Фев. 1, 2025

Constructing task-state large-scale brain networks can enhance our understanding of the organization functions during cognitive tasks. The primary goal network partitioning is to cluster functionally homogeneous regions. However, a region often serves multiple functions, complicating process. This study proposes novel clustering method for based on specific selecting semantic representation as target function evaluate validity proposed method. Specifically, we analyzed functional magnetic resonance imaging (fMRI) data from 11 subjects, each exposed 672 concepts, and correlated this with rating related these concepts. We identified distinct concept comprehension task validated robustness through methods. found that derived multidimensional activation exhibit high reliability cross-semantic model consistency (semantic ratings word embeddings extracted GPT-2), particularly in associated functions. Moreover, exhibits significant differences resting-state task-based obtained using traditional Further analysis revealed between networks, including disparities their capabilities, information modalities they rely acquire information, varying associations general domains. introduces approach analyzing tailored establishing standard parcellation seven future research, potentially enriching complex processes neural bases.

Язык: Английский

Процитировано

1

Mapping effective connectivity of human amygdala subdivisions with intracranial stimulation DOI Creative Commons
Masahiro Sawada, Ralph Adolphs, Brian J. Dlouhy

и другие.

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Авг. 20, 2022

The primate amygdala is a complex consisting of over dozen nuclei that have been implicated in host cognitive functions, individual differences, and psychiatric illnesses. These functions are implemented through distinct connectivity profiles, which documented animals but remain largely unknown humans. Here we present results from 25 neurosurgical patients who had concurrent electrical stimulation the with intracranial electroencephalography (electrical tract-tracing; es-TT), or fMRI fMRI; es-fMRI), methods providing strong inferences about effective subdivisions rest brain. We quantified functional medial lateral amygdala, temporal order these connections on timescale milliseconds, also detail second-order among key nodes. findings provide uniquely detailed characterization human will inform neuroimaging studies healthy clinical populations.

Язык: Английский

Процитировано

28

Changes in patterns of age-related network connectivity are associated with risk for schizophrenia DOI Creative Commons
Roberta Passiatore, Linda A. Antonucci, Thomas P. DeRamus

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2023, Номер 120(32)

Опубликована: Авг. 1, 2023

Alterations in fMRI-based brain functional network connectivity (FNC) are associated with schizophrenia (SCZ) and the genetic risk or subthreshold clinical symptoms preceding onset of SCZ, which often occurs early adulthood. Thus, age-sensitive FNC changes may be relevant to SCZ risk-related FNC. We used independent component analysis estimate from childhood adulthood 9,236 individuals. To capture individual features more accurately than single-session fMRI, we studied an average three fMRI scans per individual. identify potential familial changes, compared age-related first-degree relatives patients mostly including unaffected siblings (SIB) neurotypical controls (NC) at same age stage. Then, examined how polygenic scores for influenced patterns. Finally, investigated patterns adult (oSCZ) young individuals subclinical psychotic (PSY). Age-sensitive emerge during adolescence adulthood, but not before. Young SIB always followed older NC patterns, decreased a cerebellar-occipitoparietal circuit increased two prefrontal-sensorimotor circuits when NC. Two these alterations were also found oSCZ, one exhibiting reversed pattern. All linked unrelated (R

Язык: Английский

Процитировано

14