medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 21, 2024
An
important
aim
in
psychiatry
is
the
establishment
of
valid
and
reliable
associations
linking
profiles
brain
functioning
to
clinically
relevant
symptoms
behaviors
across
patient
populations.
To
advance
progress
this
area,
we
introduce
an
open
dataset
containing
behavioral
neuroimaging
data
from
241
individuals
aged
18
70,
comprising
148
meeting
diagnostic
criteria
for
a
broad
range
psychiatric
illnesses
healthy
comparison
group
93
individuals.
These
include
high-resolution
anatomical
scans,
multiple
resting-state,
task-based
functional
MRI
runs.
Additionally,
participants
completed
over
50
psychological
cognitive
assessments.
Here,
detail
available
as
well
raw
processed
derivatives.
Associations
between
processing
quality
metrics,
such
head
motion,
are
reported.
Processed
exhibit
classic
task
activation
effects
canonical
network
organization.
Overall,
provide
comprehensive
analysis-ready
transdiagnostic
dataset,
which
hope
will
accelerate
identification
illness-relevant
features
functioning,
enabling
future
discoveries
basic
clinical
neuroscience.
NeuroImage,
Год журнала:
2023,
Номер
270, С. 119946 - 119946
Опубликована: Фев. 17, 2023
Characterizing
the
optimal
fMRI
paradigms
for
detecting
behaviorally
relevant
functional
connectivity
(FC)
patterns
is
a
critical
step
to
furthering
our
knowledge
of
neural
basis
behavior.
Previous
studies
suggested
that
FC
derived
from
task
paradigms,
which
we
refer
as
task-based
FC,
are
better
correlated
with
individual
differences
in
behavior
than
resting-state
but
consistency
and
generalizability
this
advantage
across
conditions
was
not
fully
explored.
Using
data
three
tasks
Adolescent
Brain
Cognitive
Development
Study
®
(ABCD),
tested
whether
observed
improvement
behavioral
prediction
power
can
be
attributed
changes
brain
activity
induced
by
design.
We
decomposed
time
course
each
into
model
fit
(the
fitted
condition
regressors
single-subject
general
linear
model)
residuals,
calculated
their
respective
compared
performance
these
estimates
original
FC.
The
residual
at
predicting
measure
cognitive
ability
or
two
measures
on
tasks.
superior
content-specific
insofar
it
only
probed
similar
constructs
predicted
interest.
To
surprise,
parameters,
beta
regressors,
were
equally
if
more
predictive
all
measures.
These
results
showed
afforded
largely
driven
associated
Together
previous
studies,
findings
highlighted
importance
design
eliciting
meaningful
activation
patterns.
Nature Medicine,
Год журнала:
2023,
Номер
29(5), С. 1232 - 1242
Опубликована: Апрель 24, 2023
Abstract
Recent
studies
proposed
a
general
psychopathology
factor
underlying
common
comorbidities
among
psychiatric
disorders.
However,
its
neurobiological
mechanisms
and
generalizability
remain
elusive.
In
this
study,
we
used
large
longitudinal
neuroimaging
cohort
from
adolescence
to
young
adulthood
(IMAGEN)
define
neuropsychopathological
(NP)
across
externalizing
internalizing
symptoms
using
multitask
connectomes.
We
demonstrate
that
NP
might
represent
unified,
genetically
determined,
delayed
development
of
the
prefrontal
cortex
further
leads
poor
executive
function.
also
show
be
reproducible
in
multiple
developmental
periods,
preadolescence
early
adulthood,
generalizable
resting-state
connectome
clinical
samples
(the
ADHD-200
Sample
STRATIFY
&
ESTRA
Project).
conclusion,
identify
neural
basis
mental
health
disorders,
bridging
multidimensional
evidence
behavioral,
genetic
substrates.
These
findings
may
help
develop
new
therapeutic
interventions
for
comorbidities.
Frontiers in Systems Neuroscience,
Год журнала:
2021,
Номер
15
Опубликована: Апрель 8, 2021
Anatomical
tracing,
human
clinical
data,
and
stimulation
functional
imaging
have
firmly
established
the
major
role
of
(neo-)cerebellum
in
cognition
emotion.
Telencephalization
characterized
by
great
expansion
associative
cortices,
especially
prefrontal
one,
has
been
associated
with
parallel
neocerebellar
cortex,
lobule
VII,
an
increased
number
interconnections
between
these
two
cortical
structures.
These
anatomical
modifications
underlie
implication
neocerebellum
cognitive
control
complex
motor
non-motor
tasks.
In
humans,
resting
state
connectivity
used
to
determine
a
thorough
anatomo-functional
parcellation
neocerebellum.
This
technique
identified
central
networks
involving
subserving
its
function.
Neocerebellum
participates
all
intrinsic
connected
such
as
executive,
default
mode,
salience,
dorsal
ventral
attentional,
language-dedicated
networks.
The
executive
network
constitutes
main
circuit
represented
within
cortex.
Cerebellar
zones
devoted
appear
multiple,
interdigitated,
spatially
ordered
three
gradients.
Such
organization
enables
monitor
synchronize
involved
emotion,
likely
computing
internal
models.
Neuroscience & Biobehavioral Reviews,
Год журнала:
2023,
Номер
150, С. 105193 - 105193
Опубликована: Апрель 21, 2023
The
human
brain
exhibits
complex
interactions
across
micro,
meso-,
and
macro-scale
organisational
principles.
Recent
synergistic
multi-modal
approaches
have
begun
to
link
micro-scale
information
systems
level
dynamics,
transcending
hierarchies
offering
novel
perspectives
into
the
brain's
function
dysfunction.
Specifically,
distribution
of
properties
(such
as
receptor
density
or
gene
expression)
can
be
mapped
onto
measures
from
functional
MRI
provide
neurobiological
insights.
Methodological
enrich
imaging
analyses
with
molecular
are
rapidly
evolving,
several
streams
research
having
developed
relatively
independently,
each
unique
potential
explore
trans-hierarchical
functioning
brain.
Here,
we
address
three
principal
-
spatial
correlation,
molecular-enriched
network,
in-silico
whole
modelling
a
critical
overview
different
sources
information,
how
this
utilised
within
fMRI
data,
merits
pitfalls
methodology,
and,
through
use
key
examples,
highlight
their
promise
shed
new
light
on
domains
neuroscientific
inquiry.
Functional
magnetic
resonance
imaging
(fMRI)
studies
have
documented
cerebellar
activity
across
a
wide
array
of
tasks.
However,
the
functional
contribution
cerebellum
within
these
task
domains
remains
unclear
because
is
often
studied
in
isolation.
This
problematic,
as
fMRI
may
simply
reflect
transmission
neocortical
through
fixed
connections.
Here,
we
present
new
approach
that
addresses
this
problem.
Rather
than
focus
on
task-dependent
changes
alone,
ask
if
inputs
to
are
gated
manner.
We
hypothesize
input
upregulated
when
functionally
contributes
task.
first
validated
using
finger
movement
task,
where
integrity
has
been
shown
be
essential
for
coordination
rapid
alternating
movements
but
not
force
generation.
While
both
and
increased
with
increasing
speed
force,
speed-related
were
larger
predicted
by
an
optimized
cortico-cerebellar
connectivity
model.
then
applied
same
cognitive
domain,
assessing
how
supports
working
memory.
Enhanced
gating
was
associated
encoding
items
memory,
manipulation
or
retrieval
items.
Focusing
offers
promising
understand
specific
contributions
function.
Biomedical Optics Express,
Год журнала:
2025,
Номер
16(2), С. 643 - 643
Опубликована: Янв. 6, 2025
Stroke-induced
hand
motor
impairments
have
a
significant
impact
on
the
daily
lives
of
patients.
Motor
rehabilitation
with
tactile
feedback
(TF)
shows
promise
as
an
effective
intervention;
however,
its
neural
mechanisms
are
still
not
fully
understood.
The
main
objective
this
study
was
to
examine
effect
brain
functional
responses
during
single
movement
session
in
post-stroke
patients,
using
near-infrared
spectroscopy
(fNIRS).
changes
oxy-
and
deoxy-hemoglobin
concentrations
were
recorded
from
bilateral
prefrontal,
motor,
occipital
areas
13
patients
subacute
recovery
phase
15
healthy
controls
hand-grasping
task
TF
no-TF.
cortical
activation
responses,
connectivity,
network
properties
calculated
explore
specific
response
two
grasping
tasks.
results
showed
that
exhibited
increased
hemodynamic
cortex
tasks
TF.
However,
prefrontal
cortex,
left
sensorimotor
right
premotor
area
significantly
lower
compared
(p
<
0.05).
Additionally,
poorer
overall
function,
reductions
both
clustering
coefficient
=
0.0016),
reflecting
local
information
transfer
efficiency,
transitivity
0.0053),
representing
global
integration.
A
positive
correlation
observed
between
grip
strength
metrics
(r
0.592,
p
0.033),
well
0.590,
0.034)
indicating
greater
associated
reduced
transmission
efficiency.
These
findings
indicated
can
modulate
activity
learning
integration,
providing
evidence
for
potential
valuable
tool
stroke
rehabilitation.
Frontiers in Aging Neuroscience,
Год журнала:
2025,
Номер
17
Опубликована: Фев. 4, 2025
Introduction
Individuals
with
higher
cognitive
reserve
(CR)
are
thought
to
be
more
resilient
the
effects
of
age-related
brain
changes
on
performance.
A
potential
mechanism
CR
is
redundancy
in
network
functional
connectivity
(BFR),
which
refers
amount
time
spends
a
redundant
state,
indicating
presence
multiple
independent
pathways
between
regions.
These
can
serve
as
back-up
information
processing
routes,
providing
resiliency
stress
or
disease.
In
this
study
we
aimed
investigate
whether
BFR
modulates
association
and
performance
across
broad
range
domains.
Methods
An
open-access
neuroimaging
behavioral
dataset
(
n
=
301
healthy
participants,
18–89
years)
was
analyzed.
Cortical
gray
matter
(GM)
volume,
cortical
thickness
age,
extracted
from
structural
T1
images,
served
our
measures
life-course
related
(BC).
Cognitive
scores
were
principal
component
analysis
performed
13
tests
Multivariate
linear
regression
tested
modulating
effect
relationship
Results
PCA
revealed
three
test
components
episodic,
semantic
executive
functioning.
Increased
predicted
reduced
episodic
functioning
when
considering
GM
volume
BC.
significantly
modulated
We
found
neither
predictive
nor
performance,
significant
defining
BC
via
age.
Discussion
Our
results
suggest
that
could
metric
certain
domains,
specifically
functioning,
defined
dimensions
findings
potentially
indicate
underlying
mechanisms
CR.
NeuroImage,
Год журнала:
2025,
Номер
unknown, С. 121096 - 121096
Опубликована: Фев. 1, 2025
Constructing
task-state
large-scale
brain
networks
can
enhance
our
understanding
of
the
organization
functions
during
cognitive
tasks.
The
primary
goal
network
partitioning
is
to
cluster
functionally
homogeneous
regions.
However,
a
region
often
serves
multiple
functions,
complicating
process.
This
study
proposes
novel
clustering
method
for
based
on
specific
selecting
semantic
representation
as
target
function
evaluate
validity
proposed
method.
Specifically,
we
analyzed
functional
magnetic
resonance
imaging
(fMRI)
data
from
11
subjects,
each
exposed
672
concepts,
and
correlated
this
with
rating
related
these
concepts.
We
identified
distinct
concept
comprehension
task
validated
robustness
through
methods.
found
that
derived
multidimensional
activation
exhibit
high
reliability
cross-semantic
model
consistency
(semantic
ratings
word
embeddings
extracted
GPT-2),
particularly
in
associated
functions.
Moreover,
exhibits
significant
differences
resting-state
task-based
obtained
using
traditional
Further
analysis
revealed
between
networks,
including
disparities
their
capabilities,
information
modalities
they
rely
acquire
information,
varying
associations
general
domains.
introduces
approach
analyzing
tailored
establishing
standard
parcellation
seven
future
research,
potentially
enriching
complex
processes
neural
bases.
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Авг. 20, 2022
The
primate
amygdala
is
a
complex
consisting
of
over
dozen
nuclei
that
have
been
implicated
in
host
cognitive
functions,
individual
differences,
and
psychiatric
illnesses.
These
functions
are
implemented
through
distinct
connectivity
profiles,
which
documented
animals
but
remain
largely
unknown
humans.
Here
we
present
results
from
25
neurosurgical
patients
who
had
concurrent
electrical
stimulation
the
with
intracranial
electroencephalography
(electrical
tract-tracing;
es-TT),
or
fMRI
fMRI;
es-fMRI),
methods
providing
strong
inferences
about
effective
subdivisions
rest
brain.
We
quantified
functional
medial
lateral
amygdala,
temporal
order
these
connections
on
timescale
milliseconds,
also
detail
second-order
among
key
nodes.
findings
provide
uniquely
detailed
characterization
human
will
inform
neuroimaging
studies
healthy
clinical
populations.
Proceedings of the National Academy of Sciences,
Год журнала:
2023,
Номер
120(32)
Опубликована: Авг. 1, 2023
Alterations
in
fMRI-based
brain
functional
network
connectivity
(FNC)
are
associated
with
schizophrenia
(SCZ)
and
the
genetic
risk
or
subthreshold
clinical
symptoms
preceding
onset
of
SCZ,
which
often
occurs
early
adulthood.
Thus,
age-sensitive
FNC
changes
may
be
relevant
to
SCZ
risk-related
FNC.
We
used
independent
component
analysis
estimate
from
childhood
adulthood
9,236
individuals.
To
capture
individual
features
more
accurately
than
single-session
fMRI,
we
studied
an
average
three
fMRI
scans
per
individual.
identify
potential
familial
changes,
compared
age-related
first-degree
relatives
patients
mostly
including
unaffected
siblings
(SIB)
neurotypical
controls
(NC)
at
same
age
stage.
Then,
examined
how
polygenic
scores
for
influenced
patterns.
Finally,
investigated
patterns
adult
(oSCZ)
young
individuals
subclinical
psychotic
(PSY).
Age-sensitive
emerge
during
adolescence
adulthood,
but
not
before.
Young
SIB
always
followed
older
NC
patterns,
decreased
a
cerebellar-occipitoparietal
circuit
increased
two
prefrontal-sensorimotor
circuits
when
NC.
Two
these
alterations
were
also
found
oSCZ,
one
exhibiting
reversed
pattern.
All
linked
unrelated
(R