Irx3/5 Null Deletion in Mice Blocks Cochlea‐Saccule Segregation and Disrupts the Auditory Tonotopic Map DOI Creative Commons
Bernd Fritzsch,

Xin Weng,

Ebenezer N. Yamoah

и другие.

The Journal of Comparative Neurology, Год журнала: 2024, Номер 532(12)

Опубликована: Дек. 1, 2024

A gene cadre orchestrates the normal development of sensory and non-sensory cells in inner ear, segregating cochlea with a distinct tonotopic sound frequency map, similar brain projection, five vestibular end-organs. However, role genes driving ear is largely unknown. Here, we show double deletion Iroquois homeobox 3 5 transcription factors (Irx3/5 DKO) leads to fusion saccule cochlear base. The overlying otoconia tectorial membranes are absent Irx3/5 DKO primary auditory neurons project fibers both hair cells. central neuronal projections from apex-base contour not fully segregated into dorsal ventral innervation nucleus, obliterating characteristic map. Additionally, reveals pronounced cochlear-apex-vestibular "vestibular-cochlear" nerve (VCN) bilateral connection that less noticeable wild-type control mice. Moreover, incomplete segregation apex base expands connect nuclei. results suggest mammalian derived lagena reminiscent sarcopterygians. Thus, Irx3 potential evolutionary branch-point necessary for balance-sound segregation, which fused saccule-cochlea organization.

Язык: Английский

Casz1 is required for both inner hair cell fate stabilization and outer hair cell survival DOI
Yuwei Sun,

Minhui Ren,

Yu Zhang

и другие.

Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 30, 2025

Cochlear inner hair cells (IHCs) and outer (OHCs) require different transcription factors for their cell fate stabilization survival, suggesting separate mechanisms are involved. Here, we found that the factor Casz1 was crucial early IHC consolidation OHC survival during mouse development. Loss of resulted in transdifferentiation IHCs into OHCs, without affecting production. However, long-term compromised mutant mice. In addition, Gata3 down-regulated -deleted overexpressing partially rescued properties, numbers, hearing Thus, plays critical roles could potentially provide a lead therapies aimed at regenerating both OHCs.

Язык: Английский

Процитировано

1
Control of sensory cell differentiation in the inner ear by extracellular signals and transcriptional regulators DOI
Joel C. Nelson, Ishwar Hosamani, Andrew K. Groves

и другие.

Current topics in developmental biology/Current Topics in Developmental Biology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Regeneration of sensory hair cells in mature mammals DOI
Bradley J. Walters, Brandon C. Cox, Jennifer S. Stone

и другие.

Current topics in developmental biology/Current Topics in Developmental Biology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Irx3/5 Null Deletion in Mice Blocks Cochlea‐Saccule Segregation and Disrupts the Auditory Tonotopic Map DOI Creative Commons
Bernd Fritzsch,

Xin Weng,

Ebenezer N. Yamoah

и другие.

The Journal of Comparative Neurology, Год журнала: 2024, Номер 532(12)

Опубликована: Дек. 1, 2024

A gene cadre orchestrates the normal development of sensory and non-sensory cells in inner ear, segregating cochlea with a distinct tonotopic sound frequency map, similar brain projection, five vestibular end-organs. However, role genes driving ear is largely unknown. Here, we show double deletion Iroquois homeobox 3 5 transcription factors (Irx3/5 DKO) leads to fusion saccule cochlear base. The overlying otoconia tectorial membranes are absent Irx3/5 DKO primary auditory neurons project fibers both hair cells. central neuronal projections from apex-base contour not fully segregated into dorsal ventral innervation nucleus, obliterating characteristic map. Additionally, reveals pronounced cochlear-apex-vestibular "vestibular-cochlear" nerve (VCN) bilateral connection that less noticeable wild-type control mice. Moreover, incomplete segregation apex base expands connect nuclei. results suggest mammalian derived lagena reminiscent sarcopterygians. Thus, Irx3 potential evolutionary branch-point necessary for balance-sound segregation, which fused saccule-cochlea organization.

Язык: Английский

Процитировано

1