Interferons in myositis: Pathogenesis and therapy
Clinical and Experimental Neuroimmunology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 26, 2025
Abstract
Idiopathic
inflammatory
myopathies
(IIMs),
or
myositis,
are
a
heterogeneous
group
of
autoimmune
diseases
affecting
skeletal
muscle
and
other
organs.
Recent
research
has
revealed
the
important
role
interferons
(IFNs)
in
pathogenesis
IIMs.
This
review
summarizes
three
types
IFNs
their
functions
immune
system,
focusing
on
association
with
different
IIM
subtypes.
Dermatomyositis
(DM)
is
strongly
associated
Type
I
IFNs.
In
contrast,
inclusion
body
myositis
(IBM),
polymyositis
mitochondrial
pathology
(PM‐mito),
anti‐synthetase
syndrome
(ASyS)
predominantly
II
IFN.
explores
molecular
mechanisms
underlying
these
associations
impact
function.
addition,
potential
IFN
signaling
pathway
as
therapeutic
target
for
IIMs
will
be
discussed.
Several
clinical
trials
currently
underway
planned
that
using
JAK
inhibitors
monoclonal
antibodies
against
have
shown
promise
treating
DM,
particularly
refractory
cases.
However,
more
needed
to
fully
understand
efficacy
safety
profiles
The
concludes
by
highlighting
importance
ongoing
this
area
new
targeted
therapies
Язык: Английский
Elevated Serum MCP‐2 and TARC Associated With Increased Risk of Death in Guamanian ALS Patients
European Journal of Neurology,
Год журнала:
2025,
Номер
32(3)
Опубликована: Фев. 25, 2025
This
study
explores
the
relationship
between
inflammation
and
longevity
in
a
high-incidence
focus
of
amyotrophic
lateral
sclerosis
(ALS)
post-WWII
Guam.
Characteristics
this
include
sudden
appearance
disease
high
numbers
unusually
long
lifespan
(without
medical
interventions)
seen
some
cases.
We
used
bio-banked
specimens
to
evaluate
serum
immunoregulators
survival
time.
evaluated
sera
from
69
Guam
ALS
cases
collected
within
2
years
symptom
onset
by
NIH
researchers
1950
1983
for
11
via
ELISA
(CRP,
eotaxin-1,
RANTES,
IL-6,
IL-8,
IL-10,
IFN-γ,
IP-10,
MCP-1,
MCP-2
TARC).
Factor
analysis
identified
two
factors
responsible
~68%
variation
data.
estimated
Cox
proportional
hazards
models
identify
associated
with
time
death.
Each
10-unit
increase
factor
cytokines
(MCP-2
TARC)
was
38%
risk
death
(HR:
1.38;
95%
CI:
1.19,
1.65;
p:
0.00).
Like
sporadic
worldwide,
is
shortened
Guamanian
ALS;
more
specifically,
our
findings
suggest
levels
TARC
at
may
predict
duration.
Further
investigation
needed
determine
role
these
prognosis
as
targets
diagnostic
therapeutic
interventions.
Язык: Английский
Progress in the role and mechanism of TDP-43
New discovery.,
Год журнала:
2024,
Номер
unknown, С. 1 - 8
Опубликована: Сен. 20, 2024
Background:
TAR
DNA-binding
protein
43
kDa
(TDP-43)
has
been
shown
to
play
an
important
role
in
the
development
of
neurodegenerative
diseases,
but
mechanism
is
still
under
study.
Methods:
By
utilizing
“TDP43”,
“disease”,
and
“mechanism”
as
keywords,
200
related
studies
were
retrieved
downloaded
from
Pubmed
database,
including
60
articles.
We
summarized
progress
understanding
TDP-43
over
past
two
years,
focusing
on
disease
systems
classification
upstream
downstream,
connection,
improvement,
formation.
Results:
TDP-43,
when
abnormally
aggregated,
phosphorylated,
or
mislocalized,
plays
a
key
pathological
diseases.
Additionally,
its
impact
normal
reproductive
cell
formation,
development,
quantity,
activity,
well
insulin
secretion
activation
intestinal
epithelial
necrosis,
should
not
be
overlooked.
Mechanistically,
we
identified
relationship
between
expression
factors,
Enterovirus
D68
(EV-D68),
Heterogeneous
Nuclear
Ribonucleoprotein
D
(HNRNPD
AUF1),
Endoplasmic
Reticulum
Protein
57
(ERp57),
Progranulin
(PGRN),
downstream
factors
such
Meiotic
Recombination
Spo11
(Spo11),
AMP-Activated
Kinase
(AMPK),
Double-Strand-Break
Repair
Rad21
Homolog
(Rad21L),
IκB
(IKK),
TDP-43.
Conclusion:
neurodegeneration,
which,
phosphorylation,
EV-d68,
HNRNPD.
Язык: Английский