Gut Microbiota Regulates Exercise-induced Hormetic Modulation of Cognitive Function DOI Open Access
Elisa Cintado, Pablo Muela, Lucia Rodriguez

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 7, 2024

Abstract Lifestyle factors, particularly physical exercise, significantly influence brain structure and cognitive function through a hormetic effect dependent on exercise intensity duration. The underlying mechanisms of this profile remain largely unexplored. Recently, the gut microbiota, has emerged potent modulator lifestyle-induced changes behavior. Here, we demonstrate that 40-minute protocol moderate enhances abilities related to object recognition memory, increases hippocampal neurogenesis in adult mice compared sedentary controls, but these neurogenic benefits vanish when or duration is increased. Furthermore, identified significant alpha- beta-diversity distinct bacteria composition profiles microbiota associated with different regimens. Specific bacterial families showed altered relative abundances depending duration, certain families’ quantities correlating performance ( Angelakisella, Acetatifactor, Erysipelatoclostridium , Coriobacteriaceae UCG-002.). To parse causal mechanisms, fecal transplantation from exercised replicated structural improvements observed donor animals. These findings suggest effects are mediated by corresponding indicating novel mechanistic link between brain, composition.

Язык: Английский

Paternal DEHP Exposure Triggers Reproductive Toxicity in Offspring via Epigenetic Modification of H3K27me3 DOI Creative Commons
Lu Zhang, Yang Rui, Gui‐lian Xu

и другие.

Toxics, Год журнала: 2025, Номер 13(3), С. 172 - 172

Опубликована: Фев. 27, 2025

Di (2-ethylhexyl) phthalate (DEHP) is an acknowledged endocrine disruptor with male reproductive toxicity; nevertheless, the transgenerational impacts on offspring resulting from paternal exposure, along mechanisms involved, are not well understood. To develop a model of DEHP C57BL/6J mice (4-week) exposed to (5, 250, and 500 mg/kg/d) for 35 days were then bred unexposed female at ratio 1:2 produce offspring. Findings indicate that sperm quality relative sex hormones adversely affected in males F1 F2 generations, pathological damage testes apoptosis testicular cells also observed. Interestingly, increase expression levels H3K27me3 was observed tissues descendants. It further confirmed by vitro approach may down-regulate Bcl-2 plays role regulating initiation Leydig triggered MEHP (the primary metabolite DEHP). Additionally, down-regulation can be reversed treatment inhibitor GSK126. conclude, leads harm systems, epigenetic mechanism playing key mediating these effects.

Язык: Английский

Процитировано

0
Dietary mixed-oxysterols and 27-Hydroxycholesterol induce cognitive impairment by regulating gut microbiota and miR-144-3p in vivo DOI
Tao Wang, Mengwei Ju, Xiaona Zhang

и другие.

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Язык: Английский

Процитировано

0
Gut Microbiota Regulates Exercise-induced Hormetic Modulation of Cognitive Function DOI Open Access
Elisa Cintado, Pablo Muela, Lucia Rodriguez

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 7, 2024

Abstract Lifestyle factors, particularly physical exercise, significantly influence brain structure and cognitive function through a hormetic effect dependent on exercise intensity duration. The underlying mechanisms of this profile remain largely unexplored. Recently, the gut microbiota, has emerged potent modulator lifestyle-induced changes behavior. Here, we demonstrate that 40-minute protocol moderate enhances abilities related to object recognition memory, increases hippocampal neurogenesis in adult mice compared sedentary controls, but these neurogenic benefits vanish when or duration is increased. Furthermore, identified significant alpha- beta-diversity distinct bacteria composition profiles microbiota associated with different regimens. Specific bacterial families showed altered relative abundances depending duration, certain families’ quantities correlating performance ( Angelakisella, Acetatifactor, Erysipelatoclostridium , Coriobacteriaceae UCG-002.). To parse causal mechanisms, fecal transplantation from exercised replicated structural improvements observed donor animals. These findings suggest effects are mediated by corresponding indicating novel mechanistic link between brain, composition.

Язык: Английский

Процитировано

0