Paternal DEHP Exposure Triggers Reproductive Toxicity in Offspring via Epigenetic Modification of H3K27me3
Toxics,
Год журнала:
2025,
Номер
13(3), С. 172 - 172
Опубликована: Фев. 27, 2025
Di
(2-ethylhexyl)
phthalate
(DEHP)
is
an
acknowledged
endocrine
disruptor
with
male
reproductive
toxicity;
nevertheless,
the
transgenerational
impacts
on
offspring
resulting
from
paternal
exposure,
along
mechanisms
involved,
are
not
well
understood.
To
develop
a
model
of
DEHP
C57BL/6J
mice
(4-week)
exposed
to
(5,
250,
and
500
mg/kg/d)
for
35
days
were
then
bred
unexposed
female
at
ratio
1:2
produce
offspring.
Findings
indicate
that
sperm
quality
relative
sex
hormones
adversely
affected
in
males
F1
F2
generations,
pathological
damage
testes
apoptosis
testicular
cells
also
observed.
Interestingly,
increase
expression
levels
H3K27me3
was
observed
tissues
descendants.
It
further
confirmed
by
vitro
approach
may
down-regulate
Bcl-2
plays
role
regulating
initiation
Leydig
triggered
MEHP
(the
primary
metabolite
DEHP).
Additionally,
down-regulation
can
be
reversed
treatment
inhibitor
GSK126.
conclude,
leads
harm
systems,
epigenetic
mechanism
playing
key
mediating
these
effects.
Язык: Английский
Dietary mixed-oxysterols and 27-Hydroxycholesterol induce cognitive impairment by regulating gut microbiota and miR-144-3p in vivo
GeroScience,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Язык: Английский
Gut Microbiota Regulates Exercise-induced Hormetic Modulation of Cognitive Function
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 7, 2024
Abstract
Lifestyle
factors,
particularly
physical
exercise,
significantly
influence
brain
structure
and
cognitive
function
through
a
hormetic
effect
dependent
on
exercise
intensity
duration.
The
underlying
mechanisms
of
this
profile
remain
largely
unexplored.
Recently,
the
gut
microbiota,
has
emerged
potent
modulator
lifestyle-induced
changes
behavior.
Here,
we
demonstrate
that
40-minute
protocol
moderate
enhances
abilities
related
to
object
recognition
memory,
increases
hippocampal
neurogenesis
in
adult
mice
compared
sedentary
controls,
but
these
neurogenic
benefits
vanish
when
or
duration
is
increased.
Furthermore,
identified
significant
alpha-
beta-diversity
distinct
bacteria
composition
profiles
microbiota
associated
with
different
regimens.
Specific
bacterial
families
showed
altered
relative
abundances
depending
duration,
certain
families’
quantities
correlating
performance
(
Angelakisella,
Acetatifactor,
Erysipelatoclostridium
,
Coriobacteriaceae
UCG-002.).
To
parse
causal
mechanisms,
fecal
transplantation
from
exercised
replicated
structural
improvements
observed
donor
animals.
These
findings
suggest
effects
are
mediated
by
corresponding
indicating
novel
mechanistic
link
between
brain,
composition.
Язык: Английский