Clinics,
Год журнала:
2024,
Номер
79, С. 100435 - 100435
Опубликована: Янв. 1, 2024
This
study
mainly
explores
(2R,6R;
2S,6S)-HNK
and
its
compounds
whether
there
are
antidepressant
effects.
Four
HNK
were
obtained
from
2-(Chlorophenyl)
Cyclopentylmethanone.
Forced
swimming
test,
locomotor
sensitization
conditioned
location
preference
test
used
to
screen
the
activity
of
synthesized
target
compounds.
In
case
10
mg
treatment,
compared
with
saline,
immobile
time
mice
in
group,
I5
group
I6
at
1
h
7
days
had
statistical
significance.
compound
C
D
groups
glass
cylinder
area
was
significantly
different.
movement
distance
on
day
15
increased
first
day.
place
experiment,
induced
Veh
group.
The
results
forced
showed
that
may
have
certain
anti-depressant
activity.
However,
exerts
a
rapid
significant
effect
within
week,
but
duration
is
short.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Март 11, 2024
Abstract
A
central
challenge
of
neuroscience
is
to
elucidate
how
brain
function
supports
consciousness.
Here,
we
combine
the
specificity
focal
deep
stimulation
with
fMRI
coverage
entire
cortex,
in
awake
and
anaesthetised
non-human
primates.
During
propofol,
sevoflurane,
or
ketamine
anaesthesia,
subsequent
restoration
responsiveness
by
electrical
thalamus,
investigate
loss
consciousness
impacts
distributed
patterns
structure-function
organisation
across
scales.
We
report
that
activity
under
anaesthesia
increasingly
constrained
structure
scales,
coinciding
anaesthetic-induced
collapse
multiple
dimensions
hierarchical
cortical
organisation.
These
signatures
are
observed
different
anaesthetics,
they
reversed
recovery
behavioural
markers
arousal.
No
such
effects
were
upon
stimulating
ventral
lateral
demonstrating
specificity.
Overall,
identify
consistent
orchestrated
specific
thalamic
nuclei.
Anesthesiology,
Год журнала:
2024,
Номер
141(2), С. 300 - 312
Опубликована: Май 3, 2024
Background
Propofol
is
a
widely
used
intravenous
hypnotic.
Dosing
based
mostly
on
weight,
with
great
interindividual
variation
in
consumption.
Suggested
factors
affecting
propofol
requirements
include
age,
sex,
ethnicity,
anxiety,
alcohol
consumption,
smoking,
and
concomitant
valproate
use.
Genetic
have
not
been
explored.
Methods
This
study
considered
1,000
women
undergoing
breast
cancer
surgery
under
remifentanil
anesthesia.
Depth
of
anesthesia
was
monitored
State
Entropy
(GE
Healthcare,
Finland).
during
were
recorded.
DNA
from
blood
genotyped
genome-wide
array.
A
multivariable
linear
regression
model
to
assess
the
relevance
clinical
variables
select
those
be
as
covariates
association
study.
Imputed
genotype
data
explore
selected
loci
further.
In
silico
functional
annotation
possible
consequences
discovered
genetic
variants.
Additionally,
previously
reported
associations
candidate
gene
studies
tested.
Results
Body
mass
index,
smoking
status,
use,
dose
(ln[mg
·
kg−1
min−1]),
average
remained
statistically
significant
model.
Two
reached
significance
(P
<
5
×
10−8).
The
most
for
single-nucleotide
polymorphisms
rs997989
(30
kb
ROBO3),
likely
expression
another
nearby
gene,
FEZ1,
rs9518419,
close
NALCN
(sodium
leak
channel);
rs10512538
near
KCNJ2
encoding
Kir2.1
potassium
channel
showed
suggestive
=
4.7
10−7).
None
these
are
coding
variants
but
possibly
affect
regulation
genes.
pharmacokinetics
or
pharmacodynamics
data.
Conclusions
this
first
exploring
requirements,
novel
suggesting
new
biologically
relevant
pathways
general
roles
products
ROBO3/FEZ1,
NALCN,
warrant
further
studies.
Editor’s
Perspective
What
We
Already
Know
about
Topic
Article
Tells
Us
That
Is
New
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Июль 3, 2023
Abstract
A
central
challenge
of
neuroscience
is
to
elucidate
how
the
orchestration
brain
function
modulated
by
different
states
consciousness.
Here,
we
investigate
link
between
distributed
structural
and
functional
organisation
in
MRI
signals
non-human
primates,
through
bi-directional
causal
manipulations
During
varying
levels
propofol,
sevoflurane,
or
ketamine
anaesthesia,
subsequent
restoration
responsiveness
deep
stimulation
thalamus,
loss
consciousness
impacts
patterns
structure-function
across
scales.
Combining
specificity
electrical
with
global
fMRI
coverage
entire
cortex,
report
that
activity
under
anaesthesia
increasingly
constrained
structure
scales,
coinciding
anaesthetic-induced
collapse
multiple
dimensions
hierarchical
cortical
organisation.
Crucially,
show
these
signatures
are
observed
anaesthetics,
they
reversed
recovery
behavioural
markers
during
propofol
anaesthesia.
No
such
effects
were
upon
a
control
anatomical
site,
ventral
lateral
demonstrating
specificity.
Through
integrate
pharmacology
intracranial
our
results
identify
local
specific
nuclei
thalamus.
Overall,
present
work
broadens
understanding
network
supporting
consciousness,
interplay
architecture.
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
AbstractBackground
and
Objective:
The
determination
of
death
by
neurologic
criteria
(DNC)
is
completed
a
clinical
examination
alone
if
no
confounding
conditions
render
the
unreliable.
Currently,
consensus
guidelines
on
DNC
state
patient
should
be
free
any
confounders
prior
to
testing;
however,
how
these
are
reviewed
evaluated
not
specified.
This
project
aimed
investigate
assessment
medication
during
DNC.Methods:
A
28-question
survey
was
developed
study
team
Neurocritical
Care
Society
(NCS)
Research
Operations
Subcommittee.
care
practitioners
who
NCS
members
received
invitations
participate
in
an
institutional
review
board
(IRB)
–
exempt,
electronic
survey.Results:
Of
69
respondents
survey,
most
were
physicians
(48%)
or
pharmacists
(41%),
work
urban
area
(94%)
at
academic
medical
center
(78%).
Respondents
have
neurology
admitting
service
(81%),
neurocritical
unit
(91%),
guideline
that
governs
(94%).
Out
those
guideline,
83%
require
medications
majority
(89%)
do
it
pharmacist.
When
asked
reviews
(select
all
apply),
reported
90%
time
addition
(40%)
advanced
practice
providers
(28%).
Additionally,
when
ancillary
testing
appropriate,
recommended
present
centers
(74%).
However,
drug
suspected,
only
15%
said
would
pursued
‘always’
35%
‘frequently’.Conclusion:
Most
recommends/requires
DNC.
Variation
exists
utilized
setting
responsible
patients’
More
research
essential
develop
standardized
protocols
ensure
reliable
accurate
determinations
presence
confounders.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 24, 2024
Abstract
Research
into
the
role
of
thalamocortical
circuits
in
anesthesia-induced
unconsciousness
is
difficult
due
to
anatomical
and
functional
complexity.
Prior
neuroimaging
studies
have
examined
either
thalamus
as
a
whole
or
focused
on
specific
subregions,
overlooking
distinct
neuronal
subtypes
like
core
matrix
cells.
We
conducted
study
heathy
volunteers
magnetic
resonance
imaging
during
conscious
baseline,
deep
sedation,
recovery.
advanced
gradient
mapping
technique
delineate
geometry
circuits,
within
framework
unimodal-transmodal
axis
cortex.
observed
significant
shift
this
unconsciousness,
marked
by
dominance
unimodal
over
transmodal
geometry.
This
alteration
was
closely
linked
spatial
variations
density
cells
thalamus.
research
bridges
cellular
systems-level
understanding,
highlighting
crucial
thalamic
core–matrix
architecture
understanding
neural
mechanisms
states
consciousness.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Сен. 9, 2024
Research
into
the
role
of
thalamocortical
circuits
in
anesthesia-induced
unconsciousness
is
difficult
due
to
anatomical
and
functional
complexity.
Prior
neuroimaging
studies
have
examined
either
thalamus
as
a
whole
or
focused
on
specific
subregions,
overlooking
distinct
neuronal
subtypes
like
core
matrix
cells.
We
conducted
study
heathy
volunteers
magnetic
resonance
imaging
during
conscious
baseline,
deep
sedation,
recovery.
advanced
gradient
mapping
technique
delineate
geometry
circuits,
within
framework
unimodal-transmodal
axis
cortex.
Here
we
show
significant
shift
this
marked
by
transmodal-deficient
geometry.
This
alteration
closely
linked
spatial
variations
cell
composition
thalamus.
research
bridges
cellular
systems-level
understanding,
highlighting
crucial
thalamic
core-matrix
architecture
understanding
neural
mechanisms
states
consciousness.
