Study on the antidepressant activity of (2R,6R; 2S,6S)-Hydroxynorketamine (HNK) and its derivatives

Clinics, Год журнала: 2024, Номер 79, С. 100435 - 100435

Опубликована: Янв. 1, 2024

This study mainly explores (2R,6R; 2S,6S)-HNK and its compounds whether there are antidepressant effects. Four HNK were obtained from 2-(Chlorophenyl) Cyclopentylmethanone. Forced swimming test, locomotor sensitization conditioned location preference test used to screen the activity of synthesized target compounds. In case 10 mg treatment, compared with saline, immobile time mice in group, I5 group I6 at 1 h 7 days had statistical significance. compound C D groups glass cylinder area was significantly different. movement distance on day 15 increased first day. place experiment, induced Veh group. The results forced showed that may have certain anti-depressant activity. However, exerts a rapid significant effect within week, but duration is short.

Язык: Английский

Neural Network Mechanisms Underlying General Anesthesia: Cortical and Subcortical Nuclei

Neuroscience Bulletin, Год журнала: 2024, Номер 40(12), С. 1995 - 2011

Опубликована: Авг. 21, 2024

Язык: Английский