Distinct Impact of Inflammatory Versus Psychophysiological Stress on Brain‐Wide Activation of Melanocortin Receptor 4–Expressing Neurons

The FASEB Journal, Год журнала: 2025, Номер 39(7)

Опубликована: Апрель 9, 2025

ABSTRACT Central melanocortin signaling plays a critical role in maintaining energy homeostasis by regulating intake and expenditure, with impairment of this system closely related to metabolic diseases such as obesity. Among receptor subtypes, 4 (MC4R) is the primary mediator these effects within central nervous system. Accumulating evidence suggests that MC4R contributes stress‐induced disruptions feeding behavior homeostasis. However, precise neural mechanisms which stress alters activity remain incompletely understood. In study, we compared brain‐wide c‐Fos expression patterns induced two distinct paradigms: lipopolysaccharide (LPS)‐induced inflammatory restraint male mice, further examined involvement MC4R‐expressing (MC4R + ) neurons conditions. We found both stressors elicited activation brain areas associated responses well regulation. Notably, LPS‐induced stress, but not selectively activated amygdala (CeA) oval nucleus bed stria terminalis (ovBNST). These results highlight recruitment during acute offering novel insights into imbalance depending on stressor types.

Язык: Английский

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Chronic variable mild stress alters the transcriptome and signaling properties of the anterodorsal bed nucleus of the stria terminalis in a sex‐dependent manner

Journal of Neuroendocrinology, Год журнала: 2025, Номер unknown

Опубликована: Май 5, 2025

Abstract Chronic stress is a physiological state marked by dysregulation of the hypothalamic–pituitary–adrenal axis and high circulating levels hormones, such as corticosterone in mice or cortisol humans. This dysregulated may result development mood disorders, but process which this occurs still unknown. The bed nucleus stria terminalis (BNST) serves an integration center for signaling therefore likely important area disorders. project utilized chronic variable mild (CVMS) paradigm to persistently 6 weeks, followed RNA‐Sequencing anterodorsal (ad) BNST electrophysiology corticotropin‐releasing hormone‐expressing cells adBNST. Our results show significant sex biases transcriptome adBNST well effects CVMS on specifically males. Female‐biased genes are related synaptic transmission, while male‐biased RNA processing. Stress‐sensitive males transmission synapse formation. Additionally, data showed that suppressed M‐current not females. However, increased strength excitatory post‐synaptic currents females suggests differences how stress. It also more sensitive than

Язык: Английский

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Corticotropin releasing factor and norepinephrine related circuitry changes in the bed nucleus of the stria terminalis in stress and alcohol and substance use disorders

Neuropharmacology, Год журнала: 2021, Номер 201, С. 108814 - 108814

Опубликована: Окт. 6, 2021

Язык: Английский

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Increased pituitary adenylate cyclase-activating polypeptide in the central bed nucleus of the stria terminalis in mood disorders in men

Neurobiology of Disease, Год журнала: 2023, Номер 183, С. 106191 - 106191

Опубликована: Июнь 7, 2023

The mood disorders major depressive disorder (MDD) and bipolar (BD) are highly prevalent worldwide. Women more vulnerable to these psychopathologies than men. bed nucleus of the stria terminalis (BNST), amygdala, hypothalamus crucial interconnected structures involved in stress response. In disorders, systems brain put into a higher gear. BNST is implicated mood, anxiety, depression. stress-related neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) abundant central (cBNST). this study, we investigated alterations PACAP cBNST patients with disorders. Immunohistochemical (IHC) staining situ hybridization (ISH) mRNA were performed on post-mortem human samples. Quantitative IHC revealed elevated levels both MDD BD, but only men, not women. ISH was negative, indicating that produced cBNST. results support possibility innervation plays role pathophysiology

Язык: Английский

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Chronic stress and its effects on behavior, RNA expression of the bed nucleus of the stria terminalis, and the M-current of NPY neurons

Psychoneuroendocrinology, Год журнала: 2023, Номер 161, С. 106920 - 106920

Опубликована: Дек. 7, 2023

Язык: Английский

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