Artificial Organs,
Год журнала:
2024,
Номер
48(11), С. 1223 - 1250
Опубликована: Июль 18, 2024
Retinal
prostheses
offer
hope
for
individuals
with
degenerative
retinal
diseases
by
stimulating
the
remaining
cells
to
partially
restore
their
vision.
This
review
delves
into
current
advancements
in
prosthesis
technology,
a
special
emphasis
on
pivotal
role
that
image
processing
and
machine
learning
techniques
play
this
evolution.
Journal of Comparative Physiology A,
Год журнала:
2021,
Номер
208(1), С. 69 - 81
Опубликована: Окт. 22, 2021
Abstract
Cryptochromes
are
photolyase-related
blue-light
receptors
acting
as
core
components
of
the
mammalian
circadian
clock
in
cell
nuclei.
One
or
more
members
cryptochrome
protein
family
also
assumed
to
play
a
role
avian
magnetoreception,
but
primary
sensory
molecule
retina
migratory
birds
that
mediates
light-dependent
magnetic
compass
orientation
has
still
not
been
identified.
The
mRNA
2
(Cry2)
reported
be
located
nuclei
retina,
Cry2
localisation
yet
demonstrated
at
level.
Here,
we
provide
evidence
is
photoreceptor
inner
segments,
outer
nuclear
layer,
layer
and
ganglion
night-migratory
European
robins,
homing
pigeons
domestic
chickens.
At
subcellular
level,
find
both
cytoplasm
nucleus
cells
residing
these
layers.
This
broad
nucleic
expression
rather
points
for
consistent
with
function
transcription
factor,
analogous
Cry2,
speaks
against
an
involvement
magnetoreception.
Current Biology,
Год журнала:
2021,
Номер
31(23), С. 5214 - 5226.e4
Опубликована: Окт. 16, 2021
Retinal
bipolar
cells
integrate
cone
signals
at
dendritic
and
axonal
sites.
The
route,
involving
amacrine
cells,
remains
largely
uncharted.
However,
because
types
differ
in
their
spectral
sensitivities,
insights
into
cells'
integration
might
be
gained
based
on
tunings.
We
therefore
recorded
vivo
responses
of
cell
presynaptic
terminals
larval
zebrafish
to
widefield
but
spectrally
resolved
flashes
light
mapped
the
results
onto
four
cones.
This
"spectral
circuit
mapping"
allowed
explaining
∼95%
temporal
variance
a
simple
linear
model,
thereby
revealing
several
notable
rules
inner
retina.
Bipolar
were
dominated
by
red-cone
inputs,
often
alongside
equal
sign
inputs
from
blue
green
In
contrast,
UV-cone
uncorrelated
with
those
remaining
led
new
axis
opponency
where
red-,
green-,
blue-cone
"Off"
circuits
connect
"natively-On"
outermost
fraction
plexiform
layer—much
as
how
key
color
opponent
are
established
mammals.
Beyond
this,
despite
substantial
diversity
that
was
not
present
cones,
tunings
surprisingly
simple.
They
either
approximately
resembled
both
non-opponent
motifs
already
cones
or
exhibited
stereotyped
broadband
response.
this
way,
only
preserved
efficient
representations
also
diversified
them
set
up
total
six
dominant
motifs,
which
included
three
axes
opponency.
The Journal of Comparative Neurology,
Год журнала:
2022,
Номер
531(4), С. 561 - 581
Опубликована: Дек. 22, 2022
Abstract
Visual
(and
probably
also
magnetic)
signal
processing
starts
at
the
first
synapse,
which
photoreceptors
contact
different
types
of
bipolar
cells,
thereby
feeding
information
into
channels.
In
chicken
retina,
15
and
22
cell
have
been
identified
based
on
serial
electron
microscopy
single‐cell
transcriptomics,
respectively.
However,
immunohistochemical
markers
for
avian
cells
were
only
anecdotally
described
so
far.
Here,
we
systematically
tested
12
antibodies
their
ability
to
label
individual
in
bird
retina
compared
eight
most
suitable
across
distantly
related
species,
namely
domestic
chicken,
pigeon,
common
buzzard,
European
robin,
retinal
regions.
While
two
(GNB3
EGFR)
labeled
specifically
ON
addition
other
retina.
Staining
pattern
four
(CD15,
PKCα,
PKCβ,
secretagogin)
was
species‐specific.
Two
(calbindin
showed
a
expression
central
peripheral
For
found
slightly
more
somata
inner
nuclear
layer
than
OFF
somata.
contrast,
made
ribbon
synapses
plexiform
these
species.
Finally,
analyzed
photoreceptor
connectivity
selected
robin
summary,
provide
catalog
will
greatly
facilitate
analyzing
circuitry
birds
larger
scale.
Artificial Organs,
Год журнала:
2024,
Номер
48(11), С. 1223 - 1250
Опубликована: Июль 18, 2024
Retinal
prostheses
offer
hope
for
individuals
with
degenerative
retinal
diseases
by
stimulating
the
remaining
cells
to
partially
restore
their
vision.
This
review
delves
into
current
advancements
in
prosthesis
technology,
a
special
emphasis
on
pivotal
role
that
image
processing
and
machine
learning
techniques
play
this
evolution.