Oxford University Press eBooks,
Год журнала:
2024,
Номер
unknown, С. 327 - 370
Опубликована: Май 7, 2024
Abstract
‘The
neurology
of
anxiety—planning
circuits’
extends
the
anxiolytic-derived
neuropsychology
survival
circuits
(including
hippocampus
and
anterior
cingulate
cortex)
to
goal
planning
prefrontal
cortex.
It
first
discusses
results
from
issues
with
early
work
using
lesions
as
treatments
neurotic
disorders
considers
evolution
frontal
cortex
in
context
defence
hierarchy
emphasizing
fact
that
‘deeper’
areas
are
phylogenetically
more
ancient.
then
details
anatomy
cortex,
importance
active
memory
dorsal
ventral
trend
perception-action
cycles,
control
conflict.
also
describes
a
‘mesial’
linked
internal
insula
source
monitoring
arousal/attention
outputs
Goal
Inhibition
System
(GIS).
The
final
sections
integrate
these
data
into
new,
extended,
2D
theory
systems.
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 13, 2023
Abstract
Parkinson's
disease
is
a
progressive
neurodegenerative
disorder
whose
symptoms
appear
in
longitudinal
temporal
pattern
along
the
neuropathological
burden.
Before
motor
impairment,
most
patients
suffer
anxiety/depression,
common
and
disabling
emotional
comorbidities.
The
anatomical
functional
bases
of
these
comorbidities
are
not
well
established,
though
some
studies
find
that
dorsal
raphe
(DRN)
locus
coeruleus
(LC)
nuclei
affected
by
Lewy
pathology
at
early
stages
when
affective
appear.
To
establish
involvement
DRN
LC
we
use
mouse
model
accumulates
pathological
human
alpha-synuclein
under
TH
promoter
dopaminergic
noradrenergic
neurons.
Molecular,
neurophysiological,
behavioral
investigations
show
such
accumulation
neurons
progressively
alters
neuronal
integrity
catecholamine
signaling
target
areas,
bed
nucleus
stria
terminalis
(BNST)
central
amygdala
(CeA).
onset
circuit
dysfunctions
directly
linked
to
appearance
anxiety
depression-like
behaviors
this
recapitulate
present
Parkinson’s
disease.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 12, 2024
ABSTRACT
Environmental
stimuli
elicit
drug
craving
and
relapse
in
cocaine
users
by
triggering
the
retrieval
of
strong
cocaine-related
contextual
memories.
Retrieval
can
also
destabilize
memories,
requiring
reconsolidation,
a
protein
synthesis-dependent
storage
process,
to
maintain
memory
strength.
Corticotropin-releasing
factor
(CRF)
signaling
basolateral
amygdala
(BLA)
is
necessary
for
cocaine-memory
reconsolidation.
We
have
hypothesized
that
critical
source
CRF
BLA
dorsal
raphe
nucleus
(DR)
based
on
its
neurochemistry,
anatomical
connectivity,
requisite
involvement
To
test
this
hypothesis,
male
female
Sprague-Dawley
rats
received
adeno-associated
viruses
express
Gi-coupled
designer
receptors
exclusively
activated
drugs
(DREADDs)
selectively
neurons
DR
injection
cannulae
directed
at
BLA.
The
were
trained
self-administer
distinct
environmental
context
then
extinction
training
different
context.
They
briefly
re-exposed
cocaine-predictive
(reactivate)
Intra-BLA
infusions
DREADD
agonist
deschloroclozapine
(DCZ;
0.1
mM,
0.5
μL/hemisphere)
after
reactivation
attenuated
strength,
relative
vehicle
infusion.
This
was
indicated
selective,
DCZ-induced
reactivation-dependent
decrease
drug-seeking
behavior
DREADD-expressing
males
females
compared
respective
controls.
Notably,
BLA-projecting
exhibited
increased
c-Fos
expression
during
reconsolidation
co-expressed
glutamatergic
serotonergic
neuronal
markers.
Together,
these
findings
suggest
→
circuit
engaged
strength
destabilization,
phenomenon
may
be
mediated
CRF,
glutamate,
and/or
serotonin
release
Oxford University Press eBooks,
Год журнала:
2024,
Номер
unknown, С. 167 - 188
Опубликована: Май 7, 2024
Abstract
‘What
do
hippocampal
cell
fields
represent?’
argues
against
the
conventional
idea
of
‘place’
fields.
Clear
eyeblink,
time,
displace,
and
other
‘fields’
argue
place
per
se;
as
failures
most
obvious
to
map
space
either
externally
or
in
brain;
with
‘remapping’
being
inconsistent
any
truly
spatial
metric.
As
visual
firing
is
not
a
good
guide
information
coded.
Hippocampal
easily
understood
receipt
efference
copies
from
distributed
assemblies
that
code
available
goals;
dorsal
ventral
cells
largely
echoing
cortical
trends
‘where’
‘what’
goal,
respectively.
Head
direction
cells,
path
integration,
topographic
mapping
hippocampus
are
also
discussed.
Oxford University Press eBooks,
Год журнала:
2024,
Номер
unknown, С. 1 - 46
Опубликована: Май 7, 2024
Abstract
This
chapter
provides
an
overview
of
the
need
for
a
neuropsychology
anxiety,
distinction
between
anxiety
and
fear,
definition
‘anxiety’
via
actions
selective
anxiolytic
drugs,
septo-hippocampal
system
(SHS)
as
central
to
control
goal
inhibition
that
underlies
adaptive
pathological
anxiety.
A
key
hippocampal
operation
is
motivated
suppression
goals
can,
in
excess,
deliver
disorder
and,
when
weak,
catastrophic
hypermnesia.
Attraction,
repulsion,
conflict
are
controlled
by
interlinked
hierarchical
systems,
sensitivity
which
personality
traits
that,
extreme,
result
psychiatric
disorder.
The
these
systems
solution
current
problems
with
diagnosis,
reinforcement
theory
(RST)
personality,
understanding
treatment
sensitivity,
resistance,
comorbidity
disorders.
Oxford University Press eBooks,
Год журнала:
2024,
Номер
unknown, С. 327 - 370
Опубликована: Май 7, 2024
Abstract
‘The
neurology
of
anxiety—planning
circuits’
extends
the
anxiolytic-derived
neuropsychology
survival
circuits
(including
hippocampus
and
anterior
cingulate
cortex)
to
goal
planning
prefrontal
cortex.
It
first
discusses
results
from
issues
with
early
work
using
lesions
as
treatments
neurotic
disorders
considers
evolution
frontal
cortex
in
context
defence
hierarchy
emphasizing
fact
that
‘deeper’
areas
are
phylogenetically
more
ancient.
then
details
anatomy
cortex,
importance
active
memory
dorsal
ventral
trend
perception-action
cycles,
control
conflict.
also
describes
a
‘mesial’
linked
internal
insula
source
monitoring
arousal/attention
outputs
Goal
Inhibition
System
(GIS).
The
final
sections
integrate
these
data
into
new,
extended,
2D
theory
systems.
