ADULT NEUROGENESIS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM

Annual Review of Neuroscience, Год журнала: 2005, Номер 28(1), С. 223 - 250

Опубликована: Март 18, 2005

Forty years since the initial discovery of neurogenesis in postnatal rat hippocampus, investigators have now firmly established that active from neural progenitors continues throughout life discrete regions central nervous systems (CNS) all mammals, including humans. Significant progress has been made over past few understanding developmental process and regulation adult neurogenesis, proliferation, fate specification, neuronal maturation, targeting, synaptic integration newborn neurons. The function this evolutionarily conserved phenomenon, however, remains elusive mammals. Adult represents a striking example structural plasticity mature CNS environment. Advances our will not only shed light on basic principles plasticity, but also may lead to strategies for cell replacement therapy after injury or degenerative neurological diseases.

Язык: Английский

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Adult neurogenesis and functional plasticity in neuronal circuits

Nature reviews. Neuroscience, Год журнала: 2006, Номер 7(3), С. 179 - 193

Опубликована: Фев. 22, 2006

Язык: Английский

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Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

Nature, Год журнала: 2006, Номер 443(7110), С. 448 - 452

Опубликована: Сен. 1, 2006

Язык: Английский

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How stem cells age and why this makes us grow old

Nature Reviews Molecular Cell Biology, Год журнала: 2007, Номер 8(9), С. 703 - 713

Опубликована: Авг. 23, 2007

Язык: Английский

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Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

Nature, Год журнала: 2010, Номер 469(7328), С. 102 - 106

Опубликована: Ноя. 28, 2010

Язык: Английский

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Linking functional decline of telomeres, mitochondria and stem cells during ageing

Nature, Год журнала: 2010, Номер 464(7288), С. 520 - 528

Опубликована: Март 1, 2010

Язык: Английский

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Association of olfactory dysfunction with risk for future Parkinson's disease

Annals of Neurology, Год журнала: 2007, Номер 63(2), С. 167 - 173

Опубликована: Дек. 7, 2007

Although olfactory dysfunction is commonly associated with Parkinson's disease (PD), it not known whether such can predate the onset of clinical PD in a community-based population. This study examines association future development Honolulu-Asia Aging Study cohort membersOlfaction was assessed from 1991 to 1996 2,267 men aged 71 95 years who were free and dementia at time olfaction testing. Participants followed for up 8 incident RESULTS: In course follow-up, 35 diagnosed (24.6/10,000 person-years). The average age diagnosis 82.9 +/- 3.8 (range, 76-93) years, 4.0 1.9 1-8) years. During first 4 age-adjusted incidence declined 54.5/10,000 person-years lowest quartile odor identification 26.6, 8.2, 8.4/10,000 second, third, fourth quartiles, respectively (p < 0.001 trend). After adjustment other potential confounders, odds ratios 5.2 (95% confidence interval, 1.5-25.6) compared top two quartiles. relation evident beyond follow-up.Impaired by least may be useful screening tool detect those high risk later life.

Язык: Английский

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Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression

Cell, Год журнала: 2008, Номер 135(2), С. 227 - 239

Опубликована: Окт. 1, 2008

Язык: Английский

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Pattern Separation: A Common Function for New Neurons in Hippocampus and Olfactory Bulb

Neuron, Год журнала: 2011, Номер 70(4), С. 582 - 588

Опубликована: Май 1, 2011

Язык: Английский

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Adult-Born Hippocampal Dentate Granule Cells Undergoing Maturation Modulate Learning and Memory in the Brain

Journal of Neuroscience, Год журнала: 2009, Номер 29(43), С. 13532 - 13542

Опубликована: Окт. 28, 2009

Adult-born dentate granule cells (DGCs) contribute to learning and memory, yet it remains unknown when adult-born DGCs become involved in the cognitive processes. During neurogenesis, immature display distinctive physiological characteristics while undergoing morphological maturation before final integration into neural circuits. The survival activity of can be influenced by experience animal during a critical period newborn are still immature. To assess temporal importance adult we developed transgenic mouse model that allowed us transiently reduce numbers temporally regulatable manner. We found mice with reduced population at stage were deficient forming robust, long-term spatial memory displayed impaired performance extinction tasks. These results suggest undergo make important contributions memory.

Язык: Английский

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