The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

Neuron, Год журнала: 2017, Номер 96(1), С. 17 - 42

Опубликована: Сен. 1, 2017

Язык: Английский

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The Glymphatic System: A Beginner’s Guide

Neurochemical Research, Год журнала: 2015, Номер 40(12), С. 2583 - 2599

Опубликована: Май 6, 2015

Язык: Английский

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The Cellular Phase of Alzheimer’s Disease

Cell, Год журнала: 2016, Номер 164(4), С. 603 - 615

Опубликована: Фев. 1, 2016

Язык: Английский

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Clearance systems in the brain—implications for Alzheimer disease

Nature Reviews Neurology, Год журнала: 2015, Номер 11(8), С. 457 - 470

Опубликована: Июль 21, 2015

Язык: Английский

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The glymphatic pathway in neurological disorders

The Lancet Neurology, Год журнала: 2018, Номер 17(11), С. 1016 - 1024

Опубликована: Окт. 16, 2018

Язык: Английский

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The far-reaching scope of neuroinflammation after traumatic brain injury

Nature Reviews Neurology, Год журнала: 2017, Номер 13(3), С. 171 - 191

Опубликована: Фев. 10, 2017

Язык: Английский

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Glymphatic failure as a final common pathway to dementia

Science, Год журнала: 2020, Номер 370(6512), С. 50 - 56

Опубликована: Окт. 2, 2020

Sleep is evolutionarily conserved across all species, and impaired sleep a common trait of the diseased brain. quality decreases as we age, disruption regular architecture frequent antecedent to onset dementia in neurodegenerative diseases. The glymphatic system, which clears brain protein waste products, mostly active during sleep. Yet system degrades with suggesting causal relationship between disturbance symptomatic progression dementias. ties that bind sleep, aging, clearance, aggregation have shed new light on pathogenesis broad range diseases, for failure may constitute therapeutically targetable final pathway.

Язык: Английский

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The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future

Annual Review of Pathology Mechanisms of Disease, Год журнала: 2017, Номер 13(1), С. 379 - 394

Опубликована: Дек. 1, 2017

The central nervous system (CNS) is unique in being the only organ lacking lymphatic vessels to assist removal of interstitial metabolic waste products. Recent work has led discovery glymphatic system, a glial-dependent perivascular network that subserves pseudolymphatic function brain. Within pathway, cerebrospinal fluid (CSF) enters brain via periarterial spaces, passes into interstitium astrocytic aquaporin-4, and then drives perivenous drainage (ISF) its solute. Here, we review role pathway CNS physiology, factors known regulate flow, pathologic processes which breakdown CSF-ISF exchange been implicated disease initiation progression. Important areas future research, including manipulation activity aiming improve clearance therapeutic agent delivery, are also discussed.

Язык: Английский

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Revisiting the Mechanisms of CNS Immune Privilege

Trends in Immunology, Год журнала: 2015, Номер 36(10), С. 569 - 577

Опубликована: Окт. 1, 2015

Язык: Английский

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Hydrocephalus in children

The Lancet, Год журнала: 2015, Номер 387(10020), С. 788 - 799

Опубликована: Авг. 7, 2015

Язык: Английский

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