Optogenetics: 10 years of microbial opsins in neuroscience

Nature Neuroscience, Год журнала: 2015, Номер 18(9), С. 1213 - 1225

Опубликована: Авг. 26, 2015

Язык: Английский

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Re-emergence of modular brain networks in stroke recovery

Cortex, Год журнала: 2018, Номер 101, С. 44 - 59

Опубликована: Янв. 5, 2018

Язык: Английский

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Encouraging an excitable brain state: mechanisms of brain repair in stroke

Nature reviews. Neuroscience, Год журнала: 2020, Номер 22(1), С. 38 - 53

Опубликована: Ноя. 12, 2020

Язык: Английский

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Structural Disconnections Explain Brain Network Dysfunction after Stroke

Cell Reports, Год журнала: 2019, Номер 28(10), С. 2527 - 2540.e9

Опубликована: Сен. 1, 2019

Stroke causes focal brain lesions that disrupt functional connectivity (FC), a measure of activity synchronization, throughout distributed networks. It is often assumed FC disruptions reflect damage to specific cortical regions. However, an alternative explanation they the structural disconnection (SDC) white matter pathways. Here, we compare these explanations using data from 114 stroke patients. Across multiple analyses, find SDC measures outperform measures, including putative critical regions, for explaining associated with stroke. We also identify core mode structure-function covariation links severity interhemispheric SDCs widespread across patients and correlates deficits in behavioral domains. conclude lesion's impact on connectome what determines its may play particularly important role mediating after

Язык: Английский

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Low-frequency cortical activity is a neuromodulatory target that tracks recovery after stroke

Nature Medicine, Год журнала: 2018, Номер 24(8), С. 1257 - 1267

Опубликована: Июнь 15, 2018

Язык: Английский

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Reactive astrogliosis in stroke: Contributions of astrocytes to recovery of neurological function

Neurochemistry International, Год журнала: 2017, Номер 107, С. 88 - 103

Опубликована: Янв. 4, 2017

Язык: Английский

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Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging

Nature Communications, Год журнала: 2016, Номер 7(1)

Опубликована: Ноя. 11, 2016

Amyloid-β (Aβ) plaques, a hallmark of Alzheimer's disease (AD), are surrounded by regions neuronal and glial hyperactivity. We use in vivo two-photon wide-field imaging the glutamate sensor iGluSnFR to determine whether pathological changes dynamics immediate vicinity Aβ deposits APPPS1 transgenic mice could alter activity this microenvironment. In close plaques chronic states high spontaneous fluctuations observed timing responses evoked sensory stimulation exhibit slower decay rates two cortical brain areas. GLT-1 expression is reduced around upregulation ceftriaxone partially restores values control regions. conclude that toxic microenvironment surrounding results, at least partially, from enhanced levels pharmacologically increasing may be new target for early therapeutic intervention.

Язык: Английский

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Subcortical-cortical dynamical states of the human brain and their breakdown in stroke

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Авг. 29, 2022

The mechanisms controlling dynamical patterns in spontaneous brain activity are poorly understood. Here, we provide evidence that cortical dynamics the ultra-slow frequency range (<0.01-0.1 Hz) requires intact cortical-subcortical communication. Using functional magnetic resonance imaging (fMRI) at rest, identify Dynamic Functional States (DFSs), transient but recurrent clusters of and subcortical regions synchronizing frequencies. We observe shifts temporally coincident with clusters, flexibly either limbic (hippocampus/amygdala), or nuclei (thalamus/basal ganglia). Focal lesions induced by stroke, especially those damaging white matter connections between basal ganglia/thalamus cortex, provoke anomalies fraction times, dwell transitions DFSs, causing a bias toward abnormal network integration. Dynamical observed 2 weeks after stroke recover time contribute to explaining neurological impairment long-term outcome.

Язык: Английский

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Whole-brain mapping of effective connectivity by fMRI with cortex-wide patterned optogenetics

Neuron, Год журнала: 2023, Номер 111(11), С. 1732 - 1747.e6

Опубликована: Март 30, 2023

Язык: Английский

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Multisensory stimulation improves functional recovery and resting-state functional connectivity in the mouse brain after stroke

NeuroImage Clinical, Год журнала: 2017, Номер 17, С. 717 - 730

Опубликована: Дек. 2, 2017

Stroke causes direct structural damage to local brain networks and indirect functional distant regions. Neuroplasticity after stroke involves molecular changes within perilesional tissue that can be influenced by regions functionally connected the site of injury. Spontaneous recovery enhanced rehabilitative strategies, which provides experience-driven cell signaling in enhances plasticity. Functional neuroimaging humans rodents has shown spontaneous sensorimotor function is associated with resting-state connectivity (RS-FC) across networks. At level, GABAergic inhibitory interneurons modulate plasticity peri-infarct remote Among this cell-type, a decrease parvalbumin (PV)-immunoreactivity been improved behavioral outcome. Subjecting multisensory stimulation through exposure an enriched environment (EE) stroke. Yet, how relates RS-FC not determined. In study, we investigated effect EE on behavior mice stroke, if EE-related were levels PV-expressing neurons. Photothrombotic was induced cortex. Beginning 2 days housed either standard (STD) or for 12 days. Housing significantly lost tactile-proprioceptive compared STD environment. mouse measured optical intrinsic signal imaging 14 sham surgery. marked reduction several partially restored interhemispheric homotopic between spared motor regions, particularly posterior secondary motor. Compared cages, lead increased contralesional parietal retrosplenial The regional observed correlated decreased PV-immunoreactivity region. conclusion, experimental subsequent housing induces dynamic brain. Multisensory among distinct relevant controlled movements may involve PV/GABA interneurons. Our results indicate targeting neural circuitry involving hemispheres neuromodulation multimodal sensory could improve rehabilitation

Язык: Английский

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