Social Cognitive and Affective Neuroscience,
Год журнала:
2017,
Номер
12(12), С. 1983 - 1992
Опубликована: Авг. 26, 2017
Electroconvulsive
therapy
(ECT)
has
been
widely
used
to
treat
the
major
depressive
disorder
(MDD),
especially
for
treatment-resistant
depression.
However,
neuroanatomical
basis
of
ECT
remains
an
open
problem.
In
our
study,
we
combined
voxel-based
morphology
(VBM),
resting-state
functional
connectivity
(RSFC)
and
granger
causality
analysis
(GCA)
identify
longitudinal
changes
structure
function
in
23
MDD
patients
before
after
ECT.
addition,
multivariate
pattern
using
linear
support
vector
machine
(SVM)
was
applied
classify
depressed
from
25
gender,
age
education
matched
healthy
controls.
VBM
revealed
increased
gray
matter
volume
left
superficial
amygdala
The
following
RSFC
GCA
analyses
further
identified
enhanced
between
fusiform
face
area
(FFA)
effective
FFA
ECT,
respectively.
Moreover,
SVM-based
classification
achieved
accuracy
83.33%,
a
sensitivity
82.61%
specificity
84%
by
leave-one-out
cross-validation.
Our
findings
indicated
that
may
facilitate
neurogenesis
selectively
enhance
feedforward
cortical-subcortical
amygdala.
This
study
shed
new
light
on
pathological
mechanism
provide
Frontiers in Systems Neuroscience,
Год журнала:
2016,
Номер
9
Опубликована: Янв. 8, 2016
Oscillatory
neuronal
activity
may
provide
a
mechanism
for
dynamic
network
coordination.
Rhythmic
interactions
can
be
quantified
using
multiple
metrics,
each
with
their
own
advantages
and
disadvantages.
This
tutorial
will
review
summarize
current
analysis
methods
used
in
the
field
of
invasive
non-invasive
electrophysiology
to
study
connections
between
populations.
First,
we
metrics
functional
connectivity,
including
coherence,
phase
synchronization,
phase-slope
index,
Granger
causality,
specific
aim
an
intuition
how
these
work,
as
well
quantitative
definition.
Next,
highlight
number
interpretational
caveats
common
pitfalls
that
arise
when
performing
connectivity
analysis,
reference
problem,
signal
noise
ratio
volume
conduction
input
trial
sample
size
bias
problem.
These
illustrated
by
presenting
set
MATLAB-scripts,
which
executed
reader
simulate
potential
problems.
We
discuss
issues
addressed
methods.
Frontiers in Neuroscience,
Год журнала:
2019,
Номер
13
Опубликована: Июнь 6, 2019
Background:
Analysis
of
the
human
connectome
using
functional
magnetic
resonance
imaging
(fMRI)
started
in
mid-1990s
and
attracted
increasing
attention
attempts
to
discover
neural
underpinnings
cognition
neurological
disorders.
In
general,
brain
connectivity
patterns
from
fMRI
data
are
classified
as
statistical
dependencies
(functional
connectivity)
or
causal
interactions
(effective
among
various
units.
Computational
methods,
especially
graph
theory-based
have
recently
played
a
significant
role
understanding
architecture.
Objectives:
Thanks
emergence
theoretical
analysis,
main
purpose
current
paper
is
systematically
review
how
properties
can
emerge
through
distinct
neuronal
units
cognitive
applications
fMRI.
Moreover,
this
article
provides
an
overview
existing
effective
methods
used
construct
network,
along
with
their
advantages
pitfalls.
Methods:
systematic
review,
databases
Science
Direct,
Scopus,
arXiv,
Google
Scholar,
IEEE
Xplore,
PsycINFO,
PubMed,
SpringerLink
employed
for
exploring
evolution
computational
1990
present,
focusing
on
theory.
The
Cochrane
Collaboration's
tool
was
assess
risk
bias
individual
studies.
Results:
Our
results
show
that
theory
its
implications
neuroscience
researchers
since
2009
(as
Human
Connectome
Project
launched),
because
prominent
capability
characterizing
behavior
complex
systems.
Although
approach
be
generally
applied
either
during
rest
task
performance,
date,
most
articles
focused
resting-state
connectivity.
Conclusions:
This
insight
into
utilize
measures
make
neurobiological
inferences
regarding
mechanisms
underlying
well
different
PLoS Computational Biology,
Год журнала:
2017,
Номер
13(1), С. e1005268 - e1005268
Опубликована: Янв. 12, 2017
There
is
a
popular
belief
in
neuroscience
that
we
are
primarily
data
limited,
and
producing
large,
multimodal,
complex
datasets
will,
with
the
help
of
advanced
analysis
algorithms,
lead
to
fundamental
insights
into
way
brain
processes
information.
These
do
not
yet
exist,
if
they
did
would
have
no
evaluating
whether
or
algorithmically-generated
were
sufficient
even
correct.
To
address
this,
here
take
classical
microprocessor
as
model
organism,
use
our
ability
perform
arbitrary
experiments
on
it
see
methods
from
can
elucidate
Microprocessors
among
those
artificial
information
processing
systems
both
understand
at
all
levels,
overall
logical
flow,
via
gates,
dynamics
transistors.
We
show
approaches
reveal
interesting
structure
but
meaningfully
describe
hierarchy
microprocessor.
This
suggests
current
analytic
may
fall
short
meaningful
understanding
neural
systems,
regardless
amount
data.
Additionally,
argue
for
scientists
using
non-linear
dynamical
known
ground
truth,
such
validation
platform
time-series
discovery
methods.
Annual Review of Statistics and Its Application,
Год журнала:
2021,
Номер
9(1), С. 289 - 319
Опубликована: Ноя. 18, 2021
Introduced
more
than
a
half-century
ago,
Granger
causality
has
become
popular
tool
for
analyzing
time
series
data
in
many
application
domains,
from
economics
and
finance
to
genomics
neuroscience.
Despite
this
popularity,
the
validity
of
framework
inferring
causal
relationships
among
remained
topic
continuous
debate.
Moreover,
while
original
definition
was
general,
limitations
computational
tools
have
constrained
applications
primarily
simple
bivariate
vector
autoregressive
processes.
Starting
with
review
early
developments
debates,
article
discusses
recent
advances
that
address
various
shortcomings
earlier
approaches,
models
high-dimensional
account
nonlinear
non-Gaussian
observations
allow
subsampled
mixed-frequency
series.
Frontiers in Neuroscience,
Год журнала:
2016,
Номер
10
Опубликована: Ноя. 10, 2016
Functional
Magnetic
Resonance
Imaging
(fMRI)
studies
have
become
increasingly
popular
both
with
clinicians
and
researchers
as
they
are
capable
of
providing
unique
insights
into
brain
functions.
However,
multiple
technical
considerations
(ranging
from
specifics
paradigm
design
to
imaging
artifacts,
complex
protocol
definition,
multitude
processing
methods
analysis,
well
intrinsic
methodological
limitations)
must
be
considered
addressed
in
order
optimize
fMRI
analysis
arrive
at
the
most
accurate
grounded
interpretation
data.
In
practice,
researcher/clinician
choose,
many
available
options,
suitable
software
tool
for
each
stage
pipeline.
Herein
we
provide
a
straightforward
guide
designed
address,
major
stages,
techniques,
tools
involved
process.
We
developed
this
help
those
new
technique
overcome
critical
difficulties
its
use,
serve
resource
neuroimaging
community.
NeuroImage Clinical,
Год журнала:
2018,
Номер
18, С. 849 - 870
Опубликована: Янв. 1, 2018
Biomarkers
in
whichever
modality
are
tremendously
important
diagnosing
of
disease,
tracking
disease
progression
and
clinical
trials.
This
applies
particular
for
disorders
with
a
long
course
including
pre-symptomatic
stages,
which
only
subtle
signs
can
be
observed.
Magnetic
resonance
imaging
(MRI)
biomarkers
hold
promise
due
to
their
relative
ease
use,
cost-effectiveness
non-invasivity.
Studies
measuring
resting-state
functional
MR
connectivity
have
become
increasingly
common
during
recent
years
well
established
neuroscience
related
fields.
Its
increasing
application
does
also
include
settings
therein
neurodegenerative
diseases.
In
the
present
review,
we
critically
summarise
state
literature
on
as
measured
MRI
disorders.
addition
an
overview
results,
briefly
outline
methods
applied
concept
connectivity.
While
there
many
different
cumulatively
affecting
substantial
number
patients,
most
them
studies
fMRI
lacking.
Plentiful
amounts
papers
available
Alzheimer's
(AD)
Parkinson's
(PD),
but
few
works
being
less
allows
some
conclusions
potential
acting
biomarker
aforementioned
two
diseases,
tentative
statements
others.
For
AD,
contains
relatively
strong
consensus
regarding
impairment
default
mode
network
compared
healthy
individuals.
However,
AD
is
no
considerable
documentation
how
that
alteration
develops
longitudinally
disease.
PD,
research
points
towards
alterations
mainly
limbic
motor
regions
networks,
drawing
PD
has
done
caution
heterogeneity
rare
clear
drawn
published
results.
Nevertheless,
summarising
data
characteristic
Huntington's
frontotemporal
dementia,
dementia
Lewy
bodies,
multiple
systems
atrophy
spinocerebellar
ataxias.
Overall
at
this
point
time,
promising
eventual
use
biomarker,
although
remain
issues
such
reproducibility
results
lack
demonstrating
longitudinal
changes.
Improved
providing
more
precise
classifications
changes
sensitive
or
therapeutic
intervention
highly
desirable,
before
routine
could
eventually
reality.
Granger
causality
has
long
been
a
prominent
method
for
inferring
causal
interactions
between
stochastic
variables
broad
range
of
complex
physical
systems.
However,
it
recognized
that
moving
average
(MA)
component
in
the
data
presents
serious
confound
to
analysis,
as
routinely
performed
via
autoregressive
(AR)
modeling.
We
solve
this
problem
by
demonstrating
may
be
calculated
simply
and
efficiently
from
parameters
state-space
(SS)
model.
Since
SS
models
are
equivalent
models,
estimated
fashion
is
not
degraded
presence
MA
component.
This
particular
significance
when
filtered,
downsampled,
observed
with
noise,
or
subprocess
higher
dimensional
process,
since
all
these
operations-commonplace
application
domains
diverse
climate
science,
econometrics,
neurosciences-induce
show
how
causality,
conditional
unconditional,
both
time
frequency
domains,
directly
model
solution
discrete
algebraic
Riccati
equation.
Numerical
simulations
demonstrate
estimators
thus
derived
have
greater
statistical
power
smaller
bias
than
AR
estimators.
also
discuss
approach
facilitates
relaxation
assumptions
linearity,
stationarity,
homoscedasticity
underlying
current
methods,
opening
up
potentially
significant
new
areas
research
analysis.