Gastric cancer: a comprehensive review of current and future treatment strategies

Cancer and Metastasis Reviews, Год журнала: 2020, Номер 39(4), С. 1179 - 1203

Опубликована: Сен. 7, 2020

Язык: Английский

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Genetics and biology of pancreatic ductal adenocarcinoma

Genes & Development, Год журнала: 2016, Номер 30(4), С. 355 - 385

Опубликована: Фев. 15, 2016

With 5-year survival rates remaining constant at 6% and rising incidences associated with an epidemic in obesity metabolic syndrome, pancreatic ductal adenocarcinoma (PDAC) is on track to become the second most common cause of cancer-related deaths by 2030. The high mortality rate PDAC stems primarily from lack early diagnosis ineffective treatment for advanced tumors. During past decade, comprehensive atlas genomic alterations, prominence specific pathways, preclinical validation such emerging targets, sophisticated model systems, molecular classification into disease subtypes have all converged illuminate drug discovery programs clearer clinical path hypotheses. A deeper understanding cancer cell biology, particularly altered metabolism impaired DNA repair processes, providing novel therapeutic strategies that show strong activity. Elucidation tumor biology principles, notably a complexity immune regulation microenvironment, has provided exciting framework reawaken system attack cells. While long road translation lies ahead, meaningful progress never been improve patient survival.

Язык: Английский

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Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

Cancer Cell, Год журнала: 2016, Номер 30(1), С. 147 - 160

Опубликована: Июль 1, 2016

Язык: Английский

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Autophagy in cancer metastasis

Oncogene, Год журнала: 2016, Номер 36(12), С. 1619 - 1630

Опубликована: Сен. 5, 2016

Autophagy is a highly conserved self-degradative process that has key role in cellular stress responses and survival. Recent work begun to explore the function of autophagy cancer metastasis, which particular interest given dearth effective therapeutic options for metastatic disease. induced upon progression various human cancers metastasis together with data from genetically engineered mice experimental models, at nearly every phase cascade been identified. Specifically, shown be involved modulating tumor cell motility invasion, stem viability differentiation, resistance anoikis, epithelial-to-mesenchymal transition, dormancy escape immune surveillance, emerging functions establishing pre-metastatic niche other aspects metastasis. In this review, we provide general overview how modulates discuss significance new findings disease management.

Язык: Английский

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Microenvironmental autophagy promotes tumour growth

Nature, Год журнала: 2017, Номер 541(7637), С. 417 - 420

Опубликована: Янв. 1, 2017

Язык: Английский

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