Progress in molecular biology and translational science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Viruses, Год журнала: 2024, Номер 16(2), С. 212 - 212
Опубликована: Янв. 31, 2024
Viruses evolve many strategies to ensure the efficient synthesis of their proteins. One such strategy is inhibition integrated stress response—the mechanism through which infected cells arrest translation phosphorylation alpha subunit eukaryotic initiation factor 2 (eIF2α). We have recently shown that human common cold betacoronavirus OC43 actively inhibits eIF2α in response sodium arsenite, a potent inducer oxidative stress. In this work, we examined modulation responses by and demonstrated negative feedback regulator GADD34 strongly induced cells. However, upregulation expression was independent from activation not required for virus-infected Our work reveals complex interplay between coronavirus response, viral protein ensured but loop disrupted.
Язык: Английский
Процитировано
4
Cell Reports, Год журнала: 2024, Номер 43(9), С. 114678 - 114678
Опубликована: Авг. 27, 2024
Viruses pose a significant threat to cellular organisms.Innate antiviral immunity encompasses both RNA-and protein-based mechanisms designed sense and respond infections, fundamental aspect present in all living organisms.A potent RNA-based mechanism is RNA interference, where small RNA-programmed nucleases target viral RNAs.Protein-based often rely on the induction of transcriptional responses triggered by recognition infections through innate immune receptors.These involve upregulation genes aimed at countering infections.In this review, we delve into recent advances understanding diversification animals.An evolutionary perspective gains losses diverse animals coupled mechanistic studies model organisms such as fruit fly Drosophila melanogaster essential provide deep that can be translated new strategies treatment diseases.
Язык: Английский
Процитировано
4
Pathogens, Год журнала: 2024, Номер 13(2), С. 113 - 113
Опубликована: Янв. 26, 2024
The respiratory tract, the first-line defense, is constantly exposed to inhaled allergens, pollutants, and pathogens such as viruses. Emerging evidence has demonstrated that coordination of innate adaptive immune responses in tract plays a crucial role protection against invading pathogens. Therefore, better understanding mucosal immunity airways critical for development novel therapeutics next-generation vaccines severe acute syndrome coronavirus 2 (SARS-CoV-2) other Since disease 2019 pandemic, our knowledge expanded. In this review, we describe latest regarding key components system tract. addition, summarize host upper lower following SARS-CoV-2 infection vaccination, discuss impact allergic airway inflammation on SARS-CoV-2.
Язык: Английский
Процитировано
3
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Июнь 10, 2024
Язык: Английский
Процитировано
3
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Сен. 5, 2024
Язык: Английский
Процитировано
3
Infection and Immunity, Год журнала: 2024, Номер 93(1)
Опубликована: Дек. 10, 2024
In contrast to adaptive immunity, which relies on memory T and B cells for long-term pathogen-specific responses, trained immunity involves the enhancement of innate immune responses through cellular reprogramming. Experimental evidence from animal models human studies supports concept its potential therapeutic applications in development personalized medicine. However, there remains a huge gap understanding mechanisms, identifying specific microbial triggers responsible induction immunity. This underscores importance investigating role redefining host defense highlights future research directions. minireview will provide comprehensive summary new paradigm or pathways. It shed light infection-induced pathways non-specific stimulation within macrophages natural killer cells, be further elaborated multiple disease perspectives caused by infectious agents such as bacteria, fungi, viruses. The article elaborates biochemical basis impact status during recurrent exposures. review concludes with perspective segment discussing benefits, limitations, challenges this area study. also sheds upon risks involved
Язык: Английский
Процитировано
3
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 2, 2025
Язык: Английский
Процитировано
0
Developmental & Comparative Immunology, Год журнала: 2025, Номер unknown, С. 105338 - 105338
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Опубликована: Фев. 20, 2025
Mounting evidence has demonstrated the genetic association of ORMDL3 (ORMDL Sphingolipid Biosynthesis Regulator 3) gene polymorphisms with bronchial asthma and a diverse set inflammatory disorders. However, its role in type I interferon (IFN) signaling remains poorly defined. Herein, we report that is negative modulator IFN by interacting MAVS (Mitochondrial Antiviral Signaling protein) subsequently promoting proteasome-mediated degradation RIG-I (Retinoic Acid-Inducible Gene I). Immunoprecipitation coupled mass spectrometry (IP-MS) assays uncovered binds to USP10 (Ubiquitin-Specific Protease 10), which forms complex stabilizes through decreasing K48-linked ubiquitination. thus disrupts interaction between RIG-I, thereby degradation. Additionally, subcutaneous syngeneic tumor models C57BL/6 mice revealed inhibition enhances anti-tumor efficacy augmenting proportion cytotoxic CD8 positive T cells production microenvironment (TME). Collectively, our findings reveal pivotal roles maintaining antiviral innate immune responses immunity.
Язык: Английский
Процитировано
0
Acta Biochimica et Biophysica Sinica, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
ISGylation is the post-translational modification of protein substrates covalently conjugated with ubiquitin-like protein, interferon-stimulated gene 15 (ISG15). Although initially linked to antiviral immunity, recent evidence highlights important roles for in various biological processes, such as maintaining genomic stability, promoting tumourigenesis, and being involved other pathological conditions. In this review, we examine molecular mechanisms underlying ISGylation, its interplay modifications, involvement diverse processes. We propose future research directions advance field discuss how might be harnessed ensure human health, particularly genome instability-associated diseases.
Язык: Английский
Процитировано
0