European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 284, С. 117180 - 117180
Опубликована: Дек. 17, 2024
Язык: Английский
Frontiers in Pharmacology, Год журнала: 2024, Номер 14
Опубликована: Янв. 11, 2024
Mitochondria are critical for cellular energetic metabolism, intracellular signaling orchestration and programmed death regulation. Therefore, mitochondrial dysfunction is associated with various pathogeneses. The maintenance of homeostasis functional recovery after injury coordinated by biogenesis, dynamics autophagy, which collectively referred to as quality control. There increasing evidence that mitochondria important targets melatonin exert protective effects under pathological conditions. Melatonin, an evolutionarily conserved tryptophan metabolite, can be synthesized, transported metabolized in mitochondria. In this review, we summarize the role damaged elimination energy supply regulating control, may provide new strategies clinical treatment mitochondria-related diseases.
Язык: Английский
Процитировано
12
Life Sciences, Год журнала: 2024, Номер 347, С. 122653 - 122653
Опубликована: Апрель 23, 2024
Язык: Английский
Процитировано
8
EMBO Reports, Год журнала: 2023, Номер 24(9)
Опубликована: Июль 19, 2023
Abstract Over the recent years, it has become apparent that a deeper understanding of cell‐to‐cell and organ‐to‐organ communication is necessary to fully comprehend both homeostatic pathological states. Autophagy indispensable for cellular development, function, homeostasis. A crucial aspect autophagy can also mediate these processes through its secretory role. The autophagy‐derived secretome relays extracellular signals in form nutrients, proteins, mitochondria, vesicles. These crosstalk mediators functionally shape cell fate decisions, tissue microenvironment systemic physiology. diversity secreted cargo elicits an equally diverse type responses, which span over metabolic, inflammatory, structural adaptations disease We review here emerging role between different types organs discuss mechanisms involved.
Язык: Английский
Процитировано
15
Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17
Опубликована: Май 13, 2024
Aging is defined as a progressive decline of cognitive and physiological functions over lifetime. Since the definition nine hallmarks aging in 2013 by López-Otin, numerous studies have attempted to identify main regulators contributors process. One interesting group proteins whose participation has been implicated several are nuclear DBF2-related (NDR) family serine-threonine AGC kinases. They one core components Hippo signaling pathway include NDR1, NDR2, LATS1 LATS2 mammals, along with its highly conserved metazoan orthologs; Trc Drosophila melanogaster , SAX-1 Caenorhabditis elegans CBK1, DBF20 Saccharomyces cerevisiae orb6 pombe . These kinases independently linked regulation widely diverse cellular processes disrupted during such cell cycle progression, transcription, intercellular communication, nutrient homeostasis, autophagy, apoptosis, stem differentiation. However, comprehensive overview state-of-the-art knowledge regarding post-translational modifications NDR not conducted. In this review, we summarize current understanding kinases, focusing on their relevance various hallmarks, emphasize growing body evidence that suggests essential across species.
Язык: Английский
Процитировано
4
Journal of Experimental & Clinical Cancer Research, Год журнала: 2024, Номер 43(1)
Опубликована: Дек. 28, 2024
Abstract On September 23–24 (2024) the 6th Workshop IRE on Translational Oncology, titled “Cancer Organoids as Reliable Disease Models to Drive Clinical Development of Novel Therapies,” took place at IRCCS Regina Elena Cancer Institute in Rome. This prominent international conference focused tumor organoids, bringing together leading experts from around world. A central challenge precision oncology is modeling dynamic ecosystem, which encompasses numerous elements that evolve spatially and temporally. Patient-derived 3D culture models, including explants, engineered or bioprinted systems, have recently emerged sophisticated tools capable capturing complexity diversity cancer cells interacting within their microenvironments. These models address critical unmet needs medicine, particularly aiding clinical decision-making. The rapid development these human tissue avatars has enabled advanced cellular alterations disease states screening compounds uncover novel therapeutic pathways. Throughout event, distinguished speakers shared expertise research findings, illustrating how organoids are transforming our understanding treatment resistance, metastatic dynamics, interaction between tumors surrounding microenvironment. served a pivotal opportunity strengthen collaborations spark innovative translational approaches. Its goal was accelerate shift preclinical application, paving way for increasingly personalized effective therapies.
Язык: Английский
Процитировано
3
Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111648 - 111648
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13
Опубликована: Май 2, 2025
Neurodegenerative diseases (NDs) such as Alzheimer’s, Parkinson’s and Huntington’s well ataxias fronto-temporal disorders are all characterized by the progressive accumulation of protein aggregates (amyloids) into inclusions bodies. In addition, recent experimental evidence is challenging conventional view disease revealing ability some these disease-relevant proteins to be transferred between cells means extracellular vesicles (EVs), allowing mutant seed oligomers involving both wild type forms protein. Abnormal secretion levels EVs closely related pathogenesis neurodegenerative contribute progression. Numerous studies have proposed therapeutic targets or biomarkers for diseases. this review, we summarize discuss role small heat shock (sHSPs) autophagy in cellular quality control turn-over major aggregation-prone associated disorders. We also highlight advanced research progress on mechanisms regulating unconventional secretion, secretory biogenesis their contribution pathological processes underlining Finally, outline latest roles potential diagnostic significance treatment clinically relevant conditions.
Язык: Английский
Процитировано
0
Gynecology and Minimally Invasive Therapy, Год журнала: 2025, Номер 14(2), С. 109 - 117
Опубликована: Апрель 1, 2025
Abstract Cell death plays a pivotal role in multitude of biological processes, including embryonic development, organ maintenance, aging, immune response, and autoimmunity. These processes are underpinned by distinct molecular mechanisms have significant implications for systems. Currently, research on regulatory cell (RCD) is primarily focused apoptosis, necroptosis, pyroptosis, ferroptosis, cuproptosis, autophagy. pathways been shown to play crucial regulating the tumor microenvironment (TME) influencing clinical outcome cancer immunotherapy. RCD exerts dual effect TME, releasing intracellular components distribution cells. cells involved fine-tuning antitumor response TME. The treatment gynecological tumors frequently presents challenge due lack immunotherapeutic responsiveness. This review will focus It explore how messengers released during these their complex interactions with tissues as well response. also analyze immunological consequences regulated its potential impact future development oncology therapy. By investigating death, we can gain insight into potentially identify new therapeutic strategies enhance efficacy existing treatments advance care.
Язык: Английский
Процитировано
0
Frontiers in Endocrinology, Год журнала: 2025, Номер 16
Опубликована: Июнь 5, 2025
Degeneration of articular cartilage is the hallmark pathologic change in osteoarthritis (OA). Cartilage not only serves as a shock-absorbing structure for movement but also regulated by organs other than bone, while chondrocytes secrete cytokines that influence these organs. The concept organ axis refers to regulatory pathways formed between via cytokine signaling. communication network established and constitutes cartilage-organ axis. Through this axis, regulate chondrocyte proliferation apoptosis. It evident play central role connecting various progression OA, prompting interest strategies intervene damage modulating This review presents, first time, system summarizing effects extraosseous on through factors alter OA progression. aim fully elucidate different cartilage, thus providing insights into treatment systemic diseases.
Язык: Английский
Процитировано
0
Journal of Extracellular Biology, Год журнала: 2024, Номер 3(6)
Опубликована: Май 30, 2024
Chemoresistance is a common problem in ovarian cancer (OvCa) treatment, where resistant cells, response to chemotherapy, secrete small extracellular vesicles (sEVs), known as chemo-sEVs, that transfer resistance recipient cells. sEVs are formed intraluminal (ILVs) within multivesicular endosomes (MVEs), whose trafficking regulated by Ras-associated binding (RAB) GTPases mediate secretion or lysosomal degradation. A decrease function can promote secretion, but the relationship between MVEs pathways and OvCa chemoresistance unclear. Here, we show A2780cis cisplatin (CCDP) cells had an increased number of ILVs structures, higher levels Endosomal Sorting Complex Required for Transport (ESCRTs) machinery components, RAB27A compared A2780 CDDP-sensitive CDDP promoted chemo-sEVs enriched DNA damage proteins. exhibited poor with reduced RAB7, essential MVEs-Lysosomal trafficking. The silencing prevents Chemo-EVs reduces its restores switching them into A2780-like cellular phenotype. Enhancing rapamycin secretion. Our results suggest adjusting balance secretory could be promising strategy overcoming OvCa.
Язык: Английский
Процитировано
1