Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling DOI Creative Commons

Klara Piletič,

Amir Hossein Kayvanjoo, Felix Clemens Richter

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 17, 2024

ABSTRACT A hallmark of obesity is a pathological expansion white adipose tissue (WAT), accompanied by marked dysfunction and fibrosis. Autophagy promotes adipocyte differentiation lipid homeostasis, but its role in obese adipocytes remains incompletely understood. Here, we demonstrate that autophagy key tissue-specific regulator WAT remodelling diet-induced obesity. Importantly, loss substantially exacerbates pericellular fibrosis visceral WAT. Change architecture correlates with increased infiltration macrophages tissue-reparative, fibrotic features. We uncover regulates purine nucleoside metabolism adipocytes, preventing excessive release the catabolites xanthine hypoxanthine. Purines signal cell-extrinsically for driving macrophage polarisation towards reparative phenotype. Our findings reveal novel regulating metabolism, thereby limiting obesity-associated maintaining functional integrity Purine signals may serve as critical balance checkpoint therapeutic target diseases.

Язык: Английский

The potential influence of melatonin on mitochondrial quality control: a review DOI Creative Commons
Xudan Lei, Zhenni Xu, Lingxiao Huang

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 14

Опубликована: Янв. 11, 2024

Mitochondria are critical for cellular energetic metabolism, intracellular signaling orchestration and programmed death regulation. Therefore, mitochondrial dysfunction is associated with various pathogeneses. The maintenance of homeostasis functional recovery after injury coordinated by biogenesis, dynamics autophagy, which collectively referred to as quality control. There increasing evidence that mitochondria important targets melatonin exert protective effects under pathological conditions. Melatonin, an evolutionarily conserved tryptophan metabolite, can be synthesized, transported metabolized in mitochondria. In this review, we summarize the role damaged elimination energy supply regulating control, may provide new strategies clinical treatment mitochondria-related diseases.

Язык: Английский

Процитировано

12
Molecular mechanisms of secretory autophagy and its potential role in diseases DOI
Qin Li,

Guolong Peng,

Huimei Liu

и другие.

Life Sciences, Год журнала: 2024, Номер 347, С. 122653 - 122653

Опубликована: Апрель 23, 2024

Язык: Английский

Процитировано

10
Autophagy orchestrates the crosstalk between cells and organs DOI Creative Commons

Klara Piletič,

Ghada Alsaleh, Anna Katharina Simon

и другие.

EMBO Reports, Год журнала: 2023, Номер 24(9)

Опубликована: Июль 19, 2023

Abstract Over the recent years, it has become apparent that a deeper understanding of cell‐to‐cell and organ‐to‐organ communication is necessary to fully comprehend both homeostatic pathological states. Autophagy indispensable for cellular development, function, homeostasis. A crucial aspect autophagy can also mediate these processes through its secretory role. The autophagy‐derived secretome relays extracellular signals in form nutrients, proteins, mitochondria, vesicles. These crosstalk mediators functionally shape cell fate decisions, tissue microenvironment systemic physiology. diversity secreted cargo elicits an equally diverse type responses, which span over metabolic, inflammatory, structural adaptations disease We review here emerging role between different types organs discuss mechanisms involved.

Язык: Английский

Процитировано

16
The NDR family of kinases: essential regulators of aging DOI Creative Commons

Kevin Jonischkies,

Miguel del Ángel, Yunus Emre Demiray

и другие.

Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17

Опубликована: Май 13, 2024

Aging is defined as a progressive decline of cognitive and physiological functions over lifetime. Since the definition nine hallmarks aging in 2013 by López-Otin, numerous studies have attempted to identify main regulators contributors process. One interesting group proteins whose participation has been implicated several are nuclear DBF2-related (NDR) family serine-threonine AGC kinases. They one core components Hippo signaling pathway include NDR1, NDR2, LATS1 LATS2 mammals, along with its highly conserved metazoan orthologs; Trc Drosophila melanogaster , SAX-1 Caenorhabditis elegans CBK1, DBF20 Saccharomyces cerevisiae orb6 pombe . These kinases independently linked regulation widely diverse cellular processes disrupted during such cell cycle progression, transcription, intercellular communication, nutrient homeostasis, autophagy, apoptosis, stem differentiation. However, comprehensive overview state-of-the-art knowledge regarding post-translational modifications NDR not conducted. In this review, we summarize current understanding kinases, focusing on their relevance various hallmarks, emphasize growing body evidence that suggests essential across species.

Язык: Английский

Процитировано

5
Cancer Organoids as reliable disease models to drive clinical development of novel therapies DOI Creative Commons
Giovanni Blandino, Ronit Satchi‐Fainaro, Ingeborg Tinhofer

и другие.

Journal of Experimental & Clinical Cancer Research, Год журнала: 2024, Номер 43(1)

Опубликована: Дек. 28, 2024

Abstract On September 23–24 (2024) the 6th Workshop IRE on Translational Oncology, titled “Cancer Organoids as Reliable Disease Models to Drive Clinical Development of Novel Therapies,” took place at IRCCS Regina Elena Cancer Institute in Rome. This prominent international conference focused tumor organoids, bringing together leading experts from around world. A central challenge precision oncology is modeling dynamic ecosystem, which encompasses numerous elements that evolve spatially and temporally. Patient-derived 3D culture models, including explants, engineered or bioprinted systems, have recently emerged sophisticated tools capable capturing complexity diversity cancer cells interacting within their microenvironments. These models address critical unmet needs medicine, particularly aiding clinical decision-making. The rapid development these human tissue avatars has enabled advanced cellular alterations disease states screening compounds uncover novel therapeutic pathways. Throughout event, distinguished speakers shared expertise research findings, illustrating how organoids are transforming our understanding treatment resistance, metastatic dynamics, interaction between tumors surrounding microenvironment. served a pivotal opportunity strengthen collaborations spark innovative translational approaches. Its goal was accelerate shift preclinical application, paving way for increasingly personalized effective therapies.

Язык: Английский

Процитировано

3
AKT/mTOR mediated autophagy contributes to the self-replication of canine influenza virus in vivo and in vitro DOI

Haobo Qu,

Xin Yuan, Kehe Huang

и другие.

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111648 - 111648

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Small HSPs at the crossroad between protein aggregation, autophagy and unconventional secretion: clinical implications and potential therapeutic opportunities in the context of neurodegenerative diseases DOI Creative Commons
Raffaella Bonavita,

Fulvia Vitale,

Luigi Vittorio Verdicchio

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Май 2, 2025

Neurodegenerative diseases (NDs) such as Alzheimer’s, Parkinson’s and Huntington’s well ataxias fronto-temporal disorders are all characterized by the progressive accumulation of protein aggregates (amyloids) into inclusions bodies. In addition, recent experimental evidence is challenging conventional view disease revealing ability some these disease-relevant proteins to be transferred between cells means extracellular vesicles (EVs), allowing mutant seed oligomers involving both wild type forms protein. Abnormal secretion levels EVs closely related pathogenesis neurodegenerative contribute progression. Numerous studies have proposed therapeutic targets or biomarkers for diseases. this review, we summarize discuss role small heat shock (sHSPs) autophagy in cellular quality control turn-over major aggregation-prone associated disorders. We also highlight advanced research progress on mechanisms regulating unconventional secretion, secretory biogenesis their contribution pathological processes underlining Finally, outline latest roles potential diagnostic significance treatment clinically relevant conditions.

Язык: Английский

Процитировано

0
Exploring the Potential Value of Modulation of Cell Death in Immunotherapy of Gynecological Tumors DOI Creative Commons
Jiajun Wang, Ning Luo, Yuliang Wu

и другие.

Gynecology and Minimally Invasive Therapy, Год журнала: 2025, Номер 14(2), С. 109 - 117

Опубликована: Апрель 1, 2025

Abstract Cell death plays a pivotal role in multitude of biological processes, including embryonic development, organ maintenance, aging, immune response, and autoimmunity. These processes are underpinned by distinct molecular mechanisms have significant implications for systems. Currently, research on regulatory cell (RCD) is primarily focused apoptosis, necroptosis, pyroptosis, ferroptosis, cuproptosis, autophagy. pathways been shown to play crucial regulating the tumor microenvironment (TME) influencing clinical outcome cancer immunotherapy. RCD exerts dual effect TME, releasing intracellular components distribution cells. cells involved fine-tuning antitumor response TME. The treatment gynecological tumors frequently presents challenge due lack immunotherapeutic responsiveness. This review will focus It explore how messengers released during these their complex interactions with tissues as well response. also analyze immunological consequences regulated its potential impact future development oncology therapy. By investigating death, we can gain insight into potentially identify new therapeutic strategies enhance efficacy existing treatments advance care.

Язык: Английский

Процитировано

0
Autophagy—Unlocking New Dimensions in the Pathology and Treatment of Depression DOI Creative Commons

Qiang Luo,

Yulong Zhao,

Peng Ren

и другие.

Cells, Год журнала: 2025, Номер 14(11), С. 795 - 795

Опубликована: Май 28, 2025

Depression is a widespread mental disorder whose impact on an individual's health extends far beyond the psychological dimension. As disease with significant burden, effective treatment of depression has become major challenge for global public health. Although several hypotheses have been proposed pathogenesis depression, its pathophysiological mechanisms remain complex and not yet fully understood. Recent studies suggest that dysfunctional autophagy may play important role in development depression. Autophagy, as intracellular degradation mechanism, maintains neuronal function by removing excess proteins damaged organelles. Current evidence suggests regulation autophagic processes provide new potential targets In this paper, we review pharmacological different antidepressant drugs abnormal changes patients multiple models. Importantly, focus pathological discuss current limitations well directions future research.

Язык: Английский

Процитировано

0
Association of organs-crosstalk with the pathogenesis of osteoarthritis: cartilage as a key player DOI Creative Commons
Qin Yao, Jingkai Di, Zijian Guo

и другие.

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Июнь 5, 2025

Degeneration of articular cartilage is the hallmark pathologic change in osteoarthritis (OA). Cartilage not only serves as a shock-absorbing structure for movement but also regulated by organs other than bone, while chondrocytes secrete cytokines that influence these organs. The concept organ axis refers to regulatory pathways formed between via cytokine signaling. communication network established and constitutes cartilage-organ axis. Through this axis, regulate chondrocyte proliferation apoptosis. It evident play central role connecting various progression OA, prompting interest strategies intervene damage modulating This review presents, first time, system summarizing effects extraosseous on through factors alter OA progression. aim fully elucidate different cartilage, thus providing insights into treatment systemic diseases.

Язык: Английский

Процитировано

0