Tumor-Associated Macrophages in Tumor Immunity

Frontiers in Immunology, Год журнала: 2020, Номер 11

Опубликована: Дек. 3, 2020

Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune cell types and are generally categorized into either two functionally contrasting subtypes, namely classical activated M1 alternatively M2 macrophages. The former typically exerts anti-tumor functions, including directly mediate cytotoxicity antibody-dependent cell-mediated (ADCC) to kill tumor cells; latter can promote occurrence metastasis cells, inhibit T response, angiogenesis, lead progression. Both have high degree plasticity thus be converted each other upon microenvironment changes or therapeutic interventions. As relationship between TAMs malignant tumors becoming clearer, become a promising target for developing new cancer treatment. In this review, we summarize origin TAMs, interaction with microenvironment, up-to-date treatment strategies targeting TAMs.

Язык: Английский

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Endoplasmic reticulum stress signals in the tumour and its microenvironment

Nature reviews. Cancer, Год журнала: 2020, Номер 21(2), С. 71 - 88

Опубликована: Ноя. 19, 2020

Язык: Английский

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Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

Molecular Cell, Год журнала: 2020, Номер 78(6), С. 1019 - 1033

Опубликована: Июнь 1, 2020

Язык: Английский

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Lipid droplets: platforms with multiple functions in cancer hallmarks

Cell Death and Disease, Год журнала: 2020, Номер 11(2)

Опубликована: Фев. 6, 2020

Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play important roles in cell signaling, metabolism, membrane trafficking, and the production of inflammatory mediators. droplet biogenesis is a regulated process, accumulation these within leukocytes, epithelial cells, hepatocytes, other nonadipocyte cells frequently observed phenotype several physiologic or pathogenic situations thoroughly described during conditions. Moreover, recent years, studies have an increase intracellular different neoplastic processes, although it not clear whether directly involved establishment types malignancies. This review discusses current evidence related to biogenesis, composition functions hallmarks cancer: inflammation, increased proliferation, escape from death, hypoxia. potential markers disease targets for novel anti-inflammatory antineoplastic therapies will be discussed.

Язык: Английский

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Lipids in the tumor microenvironment: From cancer progression to treatment

Progress in Lipid Research, Год журнала: 2020, Номер 80, С. 101055 - 101055

Опубликована: Авг. 11, 2020

Язык: Английский

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Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages

Theranostics, Год журнала: 2020, Номер 11(3), С. 1016 - 1030

Опубликована: Ноя. 6, 2020

Macrophages phagocytize pathogens to initiate innate immunity and products from the tumor microenvironment (TME) mediate immunity. The loss of tumor-associated macrophage (TAM)-mediated immune responses results in suppression. To reverse this disorder, regulatory mechanism TAMs TME needs be clarified. Immune molecules (cytokines chemokines) have been widely accepted as mutual mediators signal transduction past few decades. Recently, researchers tried seek intrinsic TAM phenotypic functional changes through metabolic connections. Numerous metabolites derived identified that induce cell-cell crosstalk with TAMs. bulk cells, stromal cells produce are involved regulation Meanwhile, some regulate biological functions well. Here, we review recent reports demonstrating between

Язык: Английский

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The role of lipids in cancer progression and metastasis

Cell Metabolism, Год журнала: 2022, Номер 34(11), С. 1675 - 1699

Опубликована: Окт. 18, 2022

Язык: Английский

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Lipid metabolism in cancer progression and therapeutic strategies

MedComm, Год журнала: 2020, Номер 2(1), С. 27 - 59

Опубликована: Дек. 24, 2020

Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy producers, signaling molecules, source material for biogenesis of cell membranes. The enhanced synthesis, storage, uptake contribute to cancer progression. rewiring has been linked activation oncogenic pathways cross talk with tumor microenvironment. resulting activity favors survival proliferation cells harsh conditions within tumor. Lipid also plays a vital role immunogenicity via effects on function noncancer microenvironment, especially immune-associated cells. Targeting altered shown potential promising anticancer therapy. Here, we review recent evidence implicating contribution reprogramming progression, discuss molecular mechanisms underlying cancer, therapeutic strategies directed toward This sheds new light fully understanding context provides valuable clues targeting

Язык: Английский

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CD36-mediated metabolic crosstalk between tumor cells and macrophages affects liver metastasis

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Окт. 2, 2022

Liver metastasis is highly aggressive and treatment-refractory, partly due to macrophage-mediated immune suppression. Understanding the mechanisms leading functional reprogramming of macrophages in tumor microenvironment (TME) will benefit cancer immunotherapy. Herein, we find that scavenger receptor CD36 upregulated metastasis-associated (MAMs) deletion MAMs attenuates liver mice. contain more lipid droplets have unique capability engulfing cell-derived long-chain fatty acids, which are carried by extracellular vesicles. The lipid-enriched vesicles preferentially partitioned into via CD36, fuel trigger their tumor-promoting activities. In patients with metastases, high expression correlates protumoral M2-type infiltration, creating a immunosuppressive TME. Collectively, our findings uncover mechanism cells metabolically interact TME, suggest therapeutic potential targeting as immunotherapy for metastasis.

Язык: Английский

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Macrophage Biology and Mechanisms of Immune Suppression in Breast Cancer

Frontiers in Immunology, Год журнала: 2021, Номер 12

Опубликована: Апрель 23, 2021

Macrophages are crucial innate immune cells that maintain tissue homeostasis and defend against pathogens; however, their infiltration into tumors has been associated with adverse outcomes. Tumor-associated macrophages (TAMs) represent a significant component of the inflammatory infiltrate in breast tumors, extensive TAMs linked to poor prognosis cancer. Here, we detail how impede productive tumor immunity cycle by limiting antigen presentation reducing activation cytotoxic T lymphocytes (CTLs) while simultaneously supporting cell survival, angiogenesis, metastasis. There is an urgent need overcome TAM-mediated suppression for durable anti-tumor To date, failure fully characterize TAM biology classify multiple subsets hindered advancement therapeutic targeting. In this regard, complexity recently taken center stage owing subset diversity tightly regulated molecular metabolic phenotypes. review, reveal major gaps our knowledge functional phenotypic characterization cancer, before after treatment. Future work subsets, location, crosstalk neighboring will be critical counteract pro-tumor functions identify novel TAM-modulating strategies combinations likely enhance current therapies chemo- immuno-therapy resistance.

Язык: Английский

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