Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Авг. 4, 2023
Background
Significant
evidence
suggests
that
asthma
might
originate
from
low-grade
systemic
inflammation.
Previous
studies
have
established
a
positive
association
between
the
immune-inflammation
index
(SII)
and
inflammation
response
(SIRI)
levels
risk
of
stroke.
However,
it
remains
unclear
whether
SII,
SIRI
prevalence
stroke
are
related
in
individuals
with
asthma.
Methods
The
present
cross-sectional
study
used
data
National
Health
Nutrition
Examination
Survey
(NHANES)
conducted
1999
2018.
SII
was
calculated
using
following
formula:
(platelet
count
×
neutrophil
count)
/
lymphocyte
count.
(neutrophil
monocyte
count)/lymphocyte
Spearman
rank
correlation
coefficient
to
determine
any
SIRI,
baseline
characteristics.
Survey-weighted
logistic
regression
employed
calculate
odds
ratios
(ORs)
95%
confidence
intervals
(CIs)
prevalence.
predictive
value
for
assessed
through
receiver
operating
characteristic
(ROC)
curve
analysis,
area
under
ROC
(AUC)
being
indicative
its
value.
Additionally,
clinical
models
including
coronary
heart
disease,
hypertension,
age,
poverty
income
ratio
were
constructed
evaluate
their
applicability.
Results
Between
2018,
5,907
NHANES
participants
identified,
which
199
experienced
stroke,
while
remaining
5,708
had
not.
analysis
indicated
neither
nor
exhibited
significant
characteristics
(r<0.1).
curves
optimal
cut-off
values
classify
into
low-
high-level
groups.
Higher
associated
higher
ORs
1.80
(95%
CI,
1.18-2.76)
2.23
1.39-3.57),
respectively.
(AUC=0.618)
superior
(AUC=0.552).
Furthermore,
model
demonstrated
good
(AUC=0.825),
sensitivity
67.1%
specificity
87.7%.
Conclusion
In
asthmatics,
significantly
increased
more
pronounced
coexisting
obesity
hyperlipidaemia.
relatively
stable
novel
inflammatory
markers
asthmatic
population,
having
better
than
SII.
Cell,
Год журнала:
2024,
Номер
187(17), С. 4637 - 4655.e26
Опубликована: Июль 22, 2024
The
medical
burden
of
stroke
extends
beyond
the
brain
injury
itself
and
is
largely
determined
by
chronic
comorbidities
that
develop
secondarily.
We
hypothesized
these
might
share
a
common
immunological
cause,
yet
effects
post-stroke
on
systemic
immunity
are
underexplored.
Here,
we
identify
myeloid
innate
immune
memory
as
cause
remote
organ
dysfunction
after
stroke.
Single-cell
sequencing
revealed
persistent
pro-inflammatory
changes
in
monocytes/macrophages
multiple
organs
up
to
3
months
injury,
notably
heart,
leading
cardiac
fibrosis
both
mice
patients.
IL-1β
was
identified
key
driver
epigenetic
memory.
These
could
be
transplanted
naive
mice,
inducing
dysfunction.
By
neutralizing
or
blocking
monocyte
trafficking
with
CCR2/5
inhibitor,
prevented
Such
immune-targeted
therapies
potentially
prevent
various
IL-1β-mediated
comorbidities,
offering
framework
for
secondary
prevention
immunotherapy.
Nature,
Год журнала:
2024,
Номер
633(8029), С. 433 - 441
Опубликована: Авг. 7, 2024
The
risk
of
early
recurrent
events
after
stroke
remains
high
despite
currently
established
secondary
prevention
strategies1.
Risk
is
particularly
in
patients
with
atherosclerosis,
more
than
10%
experiencing
events1,2.
However,
the
enormous
medical
burden
this
clinical
phenomenon,
underlying
mechanisms
leading
to
increased
vascular
and
are
largely
unknown.
Here,
using
a
novel
mouse
model
stroke-induced
ischaemia,
we
show
that
leads
activation
AIM2
inflammasome
vulnerable
atherosclerotic
plaques
via
an
increase
circulating
cell-free
DNA.
Enhanced
plaque
inflammation
post-stroke
results
destabilization
atherothrombosis,
finally
arterioarterial
embolism
within
days
index
stroke.
We
confirm
key
steps
also
experimental
myocardial
infarction
carotid
artery
samples
from
acute
Rapid
neutrophil
NETosis
was
identified
as
main
source
DNA
NET–DNA
causative
agent
activation.
Neutralization
by
DNase
treatment
or
inhibition
reduced
rate
recurrence
Our
findings
present
explanation
for
incident
ischaemic
atherosclerosis.
detailed
uncovered
here
provide
clinically
uncharted
therapeutic
targets
which
efficacy
prevent
events.
Targeting
DNA-mediated
remote
tissue
injury
represents
promising
avenue
further
development
This
study
describes
sensing
mechanism
ischemic
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 2, 2025
Background
The
systemic
immunity-inflammation
index(SII)
is
a
new
indicator
of
composite
inflammatory
response.
Inflammatory
response
an
important
pathological
process
in
stroke.
Therefore,
this
study
sought
to
investigate
the
association
between
SII
and
Methods
We
collected
data
on
participants
with
stroke
from
2015–2020
cycle
National
Health
Nutrition
Examination
Survey
(NHANES)
for
cross-sectional
investigation.
Multivariate
linear
regression
models
were
used
test
Fitted
smoothing
curves
threshold
effect
analysis
applied
describe
nonlinear
relationship.
Results
A
total
13,287
included
our
study,
including
611
(4.598%)
In
multivariate
analysis,
we
found
significant
positive
stroke,
odds
ratio
(OR)
[95%
CI]
associating
prevalence
was
[1.02
(1.01,
1.04)]
(P
<
0.01).
subgroup
interaction
experiments,
that
relationship
not
significantly
correlated
among
different
population
settings
such
as
age,
gender,
race,
education
level,
smoking
status,
high
blood
pressure,
diabetes
coronary
heart
disease
trend
>
0.05).
Moreover,
inflection
point
740
(1,000
cells
/µl)
by
using
two-segment
model.
Conclusions
This
implies
increased
levels
are
linked
To
confirm
findings,
more
large-scale
prospective
investigations
needed.
Aging Clinical and Experimental Research,
Год журнала:
2025,
Номер
37(1)
Опубликована: Янв. 21, 2025
Abstract
Background
Inflammation
and
maladaptive
immune
mechanisms
have
been
substantiated
as
integral
components
in
the
critical
pathological
processes
of
injury
cascade
ischemic
stroke
(IS).
This
study
aimed
to
explore
associations
between
six
systemic
inflammatory
indices
IS
a
Chinese
population.
Methods
was
case-control
based
on
retrospective
review
electronic
medical
records
from
two
hospitals
Shandong
Province,
China.
Systemic
indices,
including
inflammation
response
index
(SIRI),
(SII),
pan-immune-inflammation
value
(PIV),
neutrophil
lymphocyte
ratio
(NLR),
platelet
(PLR),
monocyte
(LMR),
were
calculated.
Logistic
regression
models
classification
analyses
employed
evaluate
discriminatory
abilities.
Results
In
total,
9392
participants
aged
40–83
years
old
included
discovery
(3620
pairs
IS-present
cases
healthy
controls)
validation
(1076
IS-absent
controls
with
mimics)
datasets.
After
adjusting
for
potential
confounding
factors,
found
be
associated
all
dataset,
SIRI
(odd
[OR]
8.77,
95%
confidence
interval
[CI]
7.48–10.33),
SII
(1.03,
1.01–1.04),
PIV
(1.01,
1.01–1.01),
NLR
(2.23,
2.08–2.39),
PLR
LMR
(0.77,
0.75–0.78).
Notably,
only
exhibited
significant
both
datasets
(0.88,
0.83–0.93),
suggesting
an
independent
protective
role
this
index.
SIRI,
SII,
PIV,
NLR,
showed
good
discriminative
ability
patients
dataset
(AUCs
>
0.70).
However,
they
performed
poorly
distinguishing
mimics
<
0.60).
Conclusion
provides
valuable
insights
into
IS,
offering
implications
risk
stratification.
While
these
are
indicators
conditions,
additional
biomarkers
may
needed
when
differentiating
other
chronic
conditions
clinical
practice.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
154, С. 113611 - 113611
Опубликована: Сен. 5, 2022
Cerebrovascular
diseases,
such
as
ischemic
stroke,
pose
serious
medical
challenges
worldwide
due
to
their
high
morbidity
and
mortality
limitations
in
clinical
treatment
strategies.
Studies
have
shown
that
reactive
oxygen
species
(ROS)-mediated
inflammation,
excitotoxicity,
programmed
cell
death
of
each
neurovascular
unit
during
post-stroke
hypoxia
reperfusion
play
an
important
role
the
pathological
cascade.
Ferroptosis,
a
characterized
by
iron-regulated
accumulation
lipid
peroxidation,
is
caused
abnormal
metabolism
lipids,
glutathione
(GSH),
iron,
can
accelerate
acute
central
nervous
system
injury.
Recent
studies
gradually
uncovered
process
ferroptosis
stroke.
Some
drugs
iron
chelators,
ferrostatin-1
(Fer-1)
liproxstatin-1
(Lip-1)
protect
nerves
after
injury
stroke
inhibiting
ferroptosis.
In
addition,
combined
with
our
previous
on
mediated
natural
compounds
this
review
summarized
progress
regulation
mechanism
chemical
components
herbal
recent
years,
order
provide
reference
information
for
future
research
lead
development
inhibitors.
Journal of Inflammation Research,
Год журнала:
2023,
Номер
Volume 16, С. 3699 - 3714
Опубликована: Авг. 1, 2023
Objective:
Stroke
is
a
kind
of
cerebrovascular
disease
with
high
mortality.
TMAO
has
been
shown
to
aggravate
stroke
outcomes,
but
its
mechanism
remains
unclear.
Materials
and
Methods:
Mice
were
fed
0.12%
for
16
weeks.
Then,
mice
made
into
MCAO/R
models.
Neurological
score,
infarct
volume,
neuronal
damage
markers
associated
inflammation
assessed.
Since
microglia
played
crucial
role
in
ischemic
stroke,
isolated
high-throughput
sequencing
identify
the
most
differentially
expressed
gene
following
treatment.
Afterward,
downstream
pathways
investigated
using
primary
microglia.
Results:
promoted
release
inflammatory
cytokines
brain
activation
OGD/R
microglial
inflammasome,
thereby
exacerbating
outcomes.
FTO/IGF2BP2
inhibited
NLRP3
inflammasome
by
downregulating
m6A
level
NLRP3.
can
inhibit
expression
FTO
IGF2BP2,
thus
promoting
In
conclusion,
these
results
demonstrated
that
promotes
aggravating
neurological
injury
through
FTO/IGF2BP2.
Conclusion:
Our
These
findings
explained
molecular
detail
provided
clinical
Keywords:
TMAO,
OGD/R,
microglia,
FTO,
IGF2BP2
