High-content CRISPR screening

Nature Reviews Methods Primers, Год журнала: 2022, Номер 2(1)

Опубликована: Фев. 10, 2022

Язык: Английский

---

Regulation of immune responses by the airway epithelial cell landscape

Nature reviews. Immunology, Год журнала: 2021, Номер 21(6), С. 347 - 362

Опубликована: Янв. 13, 2021

Язык: Английский

---

SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells

The EMBO Journal, Год журнала: 2020, Номер unknown, С. e105114 - e105114

Опубликована: Апрель 14, 2020

Язык: Английский

---

SingleCellSignalR: inference of intercellular networks from single-cell transcriptomics

Nucleic Acids Research, Год журнала: 2020, Номер 48(10), С. e55 - e55

Опубликована: Март 10, 2020

Single-cell transcriptomics offers unprecedented opportunities to infer the ligand-receptor (LR) interactions underlying cellular networks. We introduce a new, curated LR database and novel regularized score perform such inferences. For first time, we try assess confidence in predicted show that our outperforms other scoring schemes while controlling false positives. SingleCellSignalR is implemented as an open-access R package accessible entry-level users available from https://github.com/SCA-IRCM. Analysis results come variety of tabular graphical formats. instance, provide unique network view integrating all intercellular interactions, function relating receptors expressed intracellular pathways. A detailed comparison related tools conducted. Among various examples, demonstrate on mouse epidermis data discover oriented communication structure external basal layers.

Язык: Английский

---

Unsupervised removal of systematic background noise from droplet-based single-cell experiments using CellBender

Nature Methods, Год журнала: 2023, Номер 20(9), С. 1323 - 1335

Опубликована: Авг. 7, 2023

Язык: Английский

---