Cervicovaginal Microbiome: Physiology, Age-Related Changes, and Protective Role Against Human Papillomavirus Infection
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(5), С. 1521 - 1521
Опубликована: Фев. 24, 2025
Background/Objectives:
Persistent
high-risk
human
papillomavirus
(HPV)
infections
are
the
leading
cause
of
cervical
cancer.
Developing
evidence
suggests
that
cervicovaginal
microbiome
plays
a
significant
role
in
modulating
HPV
persistence
and
progression
to
neoplasia.
This
review
synthesizes
current
knowledge
on
interplay
between
local
immunity
infections,
emphasizing
microbial
diversity,
immune
responses,
potential
therapeutic
implications.
Methods:
A
thorough
literature
was
performed
using
Embase,
PubMed,
Scopus,
Google
Scholar,
encompassing
studies
published
2000
2024.
Studies
examining
composition
microbiome,
HPV-related
outcomes
were
evaluated
synthesized
into
comprehensive
review.
Results:
Lactobacillus-dominant
particularly
with
L.
crispatus,
creates
protective
environment
through
lactic
acid
production,
maintenance
low
pH,
anti-inflammatory
modulation,
facilitating
clearance.
Dysbiosis,
often
characterized
by
dominance
iners
overgrowth
anaerobic
bacteria,
fosters
chronic
inflammation,
cytokine
imbalance,
microenvironment
conducive
progression.
Hormonal
changes
menopause
exacerbate
these
shifts,
increasing
risk
lesions.
suggest
profiles
antimicrobial
peptides
significantly
influence
further
infection
outcomes.
Conclusions:
The
is
critical
determinant
outcomes,
for
enhance
responses
prevent
Personalized
microbiome-targeted
therapies
may
offer
novel
avenue
managing
reducing
cancer
incidence.
Язык: Английский
All Properties of Infertility Microbiome in a Review Article
Journal of Clinical Laboratory Analysis,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 9, 2025
The
microbiome
is
crucial
for
many
physiological
processes,
including
immunity,
metabolism,
and
reproduction.
This
review
aims
to
contribute
a
detailed
understanding
of
the
genital
tract,
which
can
lead
better
management
dysbiosis
reproductive
disorders.
Data
from
four
international
information
databases
Medline,
Scopus,
Embase,
Google
Scholar.
search
strategy
was
based
on
combination
following
terms:
"microbiota,"
"microbiome,"
"microfilm,"
"microflora,"
"fertility,"
or
"infertility."
advent
next-generation
sequencing-based
technologies
during
last
decade
has
revealed
presence
microbial
communities
in
nearly
every
part
human
body,
system.
Several
studies
have
shown
significant
differences
between
microbiota
vagina
endometrium,
as
well
other
parts
upper
tract.
plays
critical
role
determining
person's
health
state,
tract
may
impact
fertility
potential
before
after
assisted
treatments
(ARTs).
To
completely
understand
microbiome,
future
research
should
focus
not
only
description
but
also
interaction
bacteria,
production
biofilms,
microorganisms
with
cells.
Язык: Английский
Butyrate as a Potential Modulator in Gynecological Disease Progression
Nutrients,
Год журнала:
2024,
Номер
16(23), С. 4196 - 4196
Опубликована: Дек. 4, 2024
This
review
investigates
the
therapeutic
potential
of
butyrate,
a
short-chain
fatty
acid
(SCFA)
produced
by
gut
microbiota,
in
prevention
and
treatment
various
gynecological
diseases,
including
polycystic
ovary
syndrome
(PCOS),
endometriosis,
gynecologic
cancers
like
cervical
ovarian
cancer.
These
conditions
often
pose
challenges,
with
conventional
therapies
offering
limited
temporary
relief,
significant
side
effects,
risk
recurrence.
Emerging
evidence
highlights
butyrate's
unique
biological
activities,
particularly
its
role
as
histone
deacetylase
(HDAC)
inhibitor,
which
allows
it
to
modulate
gene
expression,
immune
responses,
inflammation.
In
PCOS,
butyrate
aids
restoring
hormonal
balance,
enhancing
insulin
sensitivity,
reducing
chronic
For
appears
suppress
dysregulation
minimize
lesion
proliferation.
Additionally,
cancers,
demonstrates
anticancer
effects
through
mechanisms
such
cell
cycle
arrest,
apoptosis
induction,
suppression
tumor
progression.
Dietary
interventions,
high-fiber
Mediterranean
diets,
that
increase
production
are
proposed
complementary
approaches,
supporting
natural
microbiota
modulation
enhance
outcomes.
However,
short
half-life
limits
clinical
application,
spurring
interest
analogs
probiotics
maintain
stable
levels
extend
benefits.
consolidates
current
findings
on
multifaceted
impact
across
health,
highlighting
for
microbiota-centered
advancing
strategies
improving
women's
reproductive
health.
Язык: Английский
Unlocking the secrets of the human gut microbiota: Comprehensive review on its role in different diseases
Jibon Kumar Paul,
Mahir Azmal,
ANM Shah Newaz Been Haque
и другие.
World Journal of Gastroenterology,
Год журнала:
2024,
Номер
31(5)
Опубликована: Дек. 30, 2024
The
human
gut
microbiota,
a
complex
and
diverse
community
of
microorganisms,
plays
crucial
role
in
maintaining
overall
health
by
influencing
various
physiological
processes,
including
digestion,
immune
function,
disease
susceptibility.
balance
between
beneficial
harmful
bacteria
is
essential
for
health,
with
dysbiosis
-
disruption
this
linked
to
numerous
conditions
such
as
metabolic
disorders,
autoimmune
diseases,
cancers.
This
review
highlights
key
genera
Enterococcus,
Ruminococcus,
Bacteroides,
Bifidobacterium,
Escherichia
coli,
Akkermansia
muciniphila,
Firmicutes
(including
Clostridium
Lactobacillus),
Roseburia
due
their
well-established
roles
regulation
but
other
bacteria,
Clostridioides
difficile,
Salmonella,
Helicobacter
pylori,
Fusobacterium
nucleatum,
are
also
implicated
diseases.
Pathogenic
coli
Bacteroides
fragilis,
contribute
inflammation
cancer
progression
disrupting
responses
damaging
tissues.
potential
microbiota-based
therapies,
probiotics,
prebiotics,
fecal
microbiota
transplantation,
dietary
interventions,
improve
outcomes
examined.
Future
research
directions
the
integration
multi-omics,
impact
diet
lifestyle
on
composition,
advancing
engineering
techniques
discussed.
Understanding
microbiota's
formulating
personalized,
efficacious
treatments
preventive
strategies,
thereby
enhancing
progressing
microbiome
research.
Язык: Английский