Renal
ischemia-reperfusion
(I/R)
injury
leads
to
irreversible
brain
damage
with
serious
consequences.
Activation
of
oxidative
stress
and
release
inflammatory
mediators
are
considered
potential
pathological
mechanisms.
Butylphthalide
(NBP)
has
anti-inflammatory
antioxidant
effects
on
I/R
injuries.
However,
it
is
unclear
whether
NBP
can
effectively
mitigate
renal
secondary
as
well
its
mechanism,
which
the
aims
this
study.
Both
rats
oxygen
glucose
deprivation
cell
models
were
established
pre-intervened
NBP.
The
Morris
water
maze
assay
was
used
detect
behavior.
Hippocampal
histopathology
function
examined
after
I/R.
Apoptosis
tube-forming
capacity
microvascular
endothelial
cells
(BMVECs)
tested.
Immunohistochemistry
Western
blot
measure
protein
expression
nuclear
factor
erythroid
2-related
2
(Nrf2)/Heme
Oxygenase-1
(HO-1)
pathway
NOD-like
receptor
C2
(NOD2)/Mitogen-activated
kinases
(MAPK)/Nuclear
kappa-B
(NF-κB)
pathway.
treatment
attenuated
I/R-induced
tissue
learning
memory
dysfunction.
inhibited
apoptosis
promoted
blood-brain
barrier
restoration
microangiogenesis.
Also,
decreased
levels
pro-inflammatory
in
rats.
Furthermore,
enhanced
BMVECs'
viability
while
inhibiting
stress.
Notably,
alleviating
attributed
Nrf2/HO-1
activation
NOD2/MAPK/NF-κB
inhibition.
This
study
demonstrates
that
maintains
BBB
by
activating
suppress
inflammation
stress,
thereby
injury.
Toxics,
Год журнала:
2025,
Номер
13(2), С. 108 - 108
Опубликована: Янв. 29, 2025
Copper
accumulation
in
neurons
induces
oxidative
stress,
disrupts
mitochondrial
activity,
and
accelerates
neuronal
death,
which
is
central
to
the
pathophysiology
of
neurodegenerative
diseases
like
Wilson
disease.
Standard
treatments
for
copper
toxicity,
such
as
D-penicillamine,
trientine,
chloroquine,
are
frequently
associated
with
severe
side
effects,
creating
a
need
safer
therapeutic
alternatives.
To
address
this,
we
developed
curcumin-loaded
nanoemulsion
(CUR-NE)
using
spontaneous
emulsification
technique,
aimed
at
enhancing
bioavailability
efficacy
curcumin.
The
optimized
displayed
particle
size
76.42
nm,
zeta
potential
−20.4
mV,
high
encapsulation
efficiency
93.69%,
stable
uniform
structure.
vitro
tests
on
SH-SY5Y
neuroblastoma
cells
demonstrated
that
CUR-NE
effectively
protected
against
copper-induced
promoting
significant
cellular
uptake.
Pharmacokinetic
studies
revealed
exhibited
longer
half-life
extended
circulation
time
compared
free
Additionally,
pharmacodynamic
evaluations,
including
biochemical
assays
histopathological
analysis,
confirmed
provided
superior
neuroprotection
overload
conditions.
These
results
emphasize
ability
augment
effects
curcumin,
presenting
novel
approach
managing
neurodegeneration.
study
highlights
effectiveness
nanoemulsion-based
delivery
platforms
improving
chelation
neurological
diseases.
Journal of Agricultural and Food Chemistry,
Год журнала:
2023,
Номер
71(5), С. 2356 - 2369
Опубликована: Янв. 31, 2023
Aging-associated
cognitive
dysfunction
has
a
great
influence
on
the
lifespan
and
healthspan
of
elderly.
Theaflavins
(TFs),
mixture
ingredients
formed
from
enzymatic
oxidation
catechins
during
manufacture
tea,
have
positive
contribution
to
qualities
antiaging
activities
black
tea.
However,
role
TFs
in
mitigating
aging-induced
underlying
mechanism
remains
largely
unknown.
Here,
we
find
that
effectively
improve
behavioral
impairment
via
microbiota-gut-brain
axis:
maintain
gut
homeostasis
by
improving
antioxidant
ability,
strengthening
immune
response,
increasing
expression
tight
junction
proteins,
restructuring
microbiota,
altering
core
microbiota
metabolites,
i.e.,
short-chain
fatty
acids
essential
amino
(SCFAs
AAs),
upregulating
brain
neurotrophic
factors.
Removing
with
antibiotics
partly
abolishes
neuroprotective
effects
TFs.
Besides,
correlation
analysis
indicates
decrease
such
as
Bacteroidetes
Lachnospiraceae,
increase
metabolites'
levels
are
positively
correlated
improvements.
Taken
together,
our
findings
reveal
potential
aging-driven
axis.
The
intake
can
be
translated
into
novel
dietary
intervention
approach
against
decline.
Nutrients,
Год журнала:
2023,
Номер
15(2), С. 392 - 392
Опубликована: Янв. 12, 2023
Neuropsychiatric
disorders
have
been
one
of
the
worldwide
health
problems
contributing
to
profound
social
and
economic
consequences.
It
is
reported
that
consumption
an
excessive
high-fat
diet
(HFD)
in
middle
age
could
induce
cognitive
emotional
dysfunctions,
whereas
mechanisms
effects
long-term
HFD
intake
on
brain
not
fully
investigated.
We
propose
a
hypothesis
prolonged
throughout
adulthood
lead
neurobehavioral
deterioration
via
gut-brain
axis.
In
this
study,
adult
C57BL/6J
mice
consuming
(24
weeks)
exhibited
more
anxiety-like,
depression-like,
disruptive
behaviors
poorer
performance
learning
memory
than
control
fed
with
normal
(ND).
addition,
homeostasis
gut
microbiota
was
impaired
by
consumption.
Changes
some
flora,
such
as
Prevotellaceae_NK3B31_group
Ruminococcus,
within
communities,
were
correlated
alterations.
Furthermore,
permeability
increased
after
due
decreased
thickness
mucus
layer
reduced
expression
tight
junction
proteins
colon.
The
mRNA
levels
genes
related
synaptic-plasticity,
neuronal
development,
microglia
maturation,
activation
hippocampus
prefrontal
cortex
HFD-fed
lower
those
ND.
Interestingly,
transcripts
proteins,
ZO-1
Occludin
involved
blood-brain-barrier
(BBB),
both
Those
results
indicated
chronic
resulted
dysbiosis,
which
induced
colon,
turn
leading
local
systemic
inflammation.
changes
further
contribute
impairment
functions
alterations,
including
mood,
sociability,
memory.
short,
behavioral
phenotypes
neuropsychiatric
observations
study
provide
potential
intervention
strategies
reduce
risk
targeting
or
manipulating
microbiota.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 24, 2025
Ginseng,
known
as
the
"king
of
herbs,"
has
long
been
used
in
traditional
Chinese
medicine
due
to
its
beneficial
properties,
including
anti-aging,
anti-inflammatory,
and
anti-apoptotic
effects.
Ginsenosides,
active
compounds
ginseng,
have
shown
promise
treating
neurodegenerative
diseases
such
Alzheimer's
disease
(AD).
This
study
investigates
therapeutic
potential
Ginsenoside
Ro
underlying
mechanisms
AD
treatment.
In
this
study,
male
APP/PS1
transgenic
mice
were
divided
into
five
groups
treated
with
or
ginseng
for
one
month.
Cognitive
function
anxiety
assessed
through
behavioral
tests,
open
field
test
(OFT)
Morris
water
maze
(MWM).
To
evaluate
Aβ
deposition,
neuronal
apoptosis,
neuroinflammation,
MAPK
pathway,
various
techniques
employed:
Thioflavin-T
staining,
Nissl
immunofluorescence,
Western
blot,
qRT-PCR
analyses.
significantly
improved
cognitive
reduced
mice.
It
also
decreased
deposition
ameliorated
apoptosis
cerebral
cortex.
The
treatment
regulated
expression
pro-apoptotic
proteins
(Bax
Caspase3)
increased
protein
Bcl-2.
Additionally,
neuroinflammation
by
decreasing
IBA1-positive
microglia
GFAP-positive
astrocytes
lowering
pro-inflammatory
cytokines
while
enhancing
anti-inflammatory
cytokine
IL-10.
Furthermore,
phosphorylation
levels
p38
JNK
pathway
reduced,
suggesting
a
key
mechanism
These
findings
provide
strong
evidence
supporting
agent
disease.
Its
effects
appear
be
mediated
modulation
IBA1/GFAP-MAPK
which
may
offer
new
insights
strategies.
